1971
DOI: 10.1111/j.1699-0463.1971.tb01866.x
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Hepatic Changes in Dogs and Rats Induced by Xylidine Isomers

Abstract: The effect of the xylidine isomers 2,4-, 2,5-, and 2,6-xylidine 011 the liver and kidneys of dogs and rats was studied. The dogs received oral doses of 2, 10, and 50 mg/kg and the rats 20, 100, and 500--700 mg/kg daily for 4 weeks. The xylidine isomers affected the liver but produced different hepatic changes in the dog and the rat. In the dog all 3 isomers induced a fatty degeneration of the liver. In the rat the 3 isomers caused a hepatomegaly mostly with a normal appearance of the liver cells. The enlargeme… Show more

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