Hepatic cysts treated with percutaneous ethanol sclerotherapy: time to extend the indications to haemorrhagic cysts and polycystic liver disease

Benzimra, Julie; Ronot, Maxime; Fuks, David; Abdel‐Rehim, Mohamed; Sibert, Annie; Farges, Olivier; Vilgrain, Valérie

doi:10.1007/s00330-014-3117-x

Cited by 40 publications

(66 citation statements)

References 43 publications

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“…Both of these forms of PLD have an autosomal dominant pattern of inheritance [55] . There are various treatments for symptomatic hepatic cysts, such as cyst aspiration sclerotherapy [26,27,30,[35][36][37][38][39][40][41][42][43][44][45] , cyst fenestration (deroofing) [28,46] , liver resection [32][33][34]47] , hepatic arterial embolization [29] , and transplantation [31] . These treatments do not alter the natural course of the disease.…”

Section: Discussionmentioning

confidence: 99%

“…Among nonsurgical treatments, a 100% recurrence rate has been reported after cyst aspiration alone; an alternative method of treatment is thus required [65] . The instillation of various sclerosing agents has been used to obliterate symptomatic congenital hepatic cysts [26,27,30,[35][36][37][38][39][40][41][42][43][44][45] . Aspiration sclerotherapy involves cyst aspiration followed by the injection of a sclerosing agent, which destroys the epithelial cells lining the cyst cavity.…”

Section: Discussionmentioning

confidence: 99%

“…The most commonly used sclerosing agent is ethanol or MINO. Ethanol injection therapy for the treatment of hepatic cysts has been associated with pain, hyperthermia, hypotension, and intoxication [35,37,44] . MINO is the antibiotic most widely used to treat cysts.…”

Section: Discussionmentioning

confidence: 99%

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Repeated Minocycline Hydrochloride Injections for Symptomatic Polycystic Liver Disease

Yoshida

Makino

Yokoyama

et al. 2016

Journal of Gastroenterology and Hepatology Research

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AIM:The present study evaluated the safety and effectiveness of repeated injections of minocycline hydrochloride (MINO) for symptomatic polycystic liver disease (PLD). METHODS:We retrospectively studied patients who received percutaneous MINO injections for symptomatic PLD and were followed up for at least 2 years between 2002 and 2015. Huge hepatic cysts (diameter > 10 cm) were treated by continuous drainage and multiple MINO injections. Small hepatic cysts underwent one-step drainage followed by a single injection of MINO. Only several cysts that caused complications were treated by percutaneous injection of MINO. Patients were discharged 1 day after treatment. RESULTS: Ten patients, (4men and 6 women; mean age, 57.8 years) were studied. All patients had Type 2 PLD according to Gigot's classification. The chief complaints were abdominal distension (n = 10), abdominal pain (n = 6), back pain (n = 4), and appetite loss (n = 8). Four patients had mild liver dysfunction. One patient complained of moderate right subscapular pain immediately after the injection, and another had pain at the site of catheter insertion. Liver dysfunction did not develop in any patient after treatment. The mean follow-up was 63.4 months. The interval from the first to last admission for MINO injection therapy was 14 to 148 months (mean, 40.8 months). The number of admissions for MINO injection therapy ranged from 2 to 12 times (mean, 4.0 times). The average interval for MINO injection therapy was 8.3 to 19 months (mean, 14.8 months).The hepatic cysts shrank in all patients after treatment. Complications improved consistently, and all patients were satisfied with the outcome of treatment. CONCLUSIONS: Symptomatic PLD was controllable by 14.8 months of repeated MINO injections on average. Repeated MINO injections are a safe, definitive treatment for symptomatic PLD.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Repeated Minocycline Hydrochloride Injections for Symptomatic Polycystic Liver Disease

Yoshida

Makino

Yokoyama

et al. 2016

Journal of Gastroenterology and Hepatology Research

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“…When there is communication with the biliary tree, cysts are usually decompressed and not distended. A relative contraindication is hemorrhagic cysts [346] though they can be treated with similar results once infection or malignancy has been excluded [342]. Ascites and planned liver transplantation are other relative contraindications.…”

Section: Contraindicationsmentioning

confidence: 99%

Untitled

2016

Ultraschall in Med

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“…Sclerotherapy induces lysis of secreting cholangiocytes that cover the inner cyst wall [5]. e literature describes the use of many di erent sclerosing agents but ethanol is most commonly applied as it is effective, safe, inexpensive, and widely available [6][7][8]. The most common side effect of AS is pain during or after the procedure [3,9,10].…”

Section: Introductionmentioning

confidence: 99%

Hepatic Cyst Infection Following Aspiration Sclerotherapy: a Case Series

Wijnands

Lantinga

Drenth

2014

JGLD

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Mass-related symptoms caused by hepatic cysts are effectively treated by aspiration sclerotherapy (AS). This minimal-invasive intervention is regarded as a safe procedure. Hence, occurrence of complications is low. Transient fever is commonly reported as a side effect. However, documentation on a post-procedural hepatic cyst infection as a complication of AS is limited. We present five cases in which a tentative diagnosis of postprocedural hepatic cyst infection was made. Patients typically presented with abdominal pain and fever, had to be admitted to our hospital, and were treated with long term antibiotics. Ultimately, the cyst infection successfully resolved with ciprofloxacin in all cases.

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Hepatic cysts treated with percutaneous ethanol sclerotherapy: time to extend the indications to haemorrhagic cysts and polycystic liver disease

Cited by 40 publications

References 43 publications

Repeated Minocycline Hydrochloride Injections for Symptomatic Polycystic Liver Disease

Repeated Minocycline Hydrochloride Injections for Symptomatic Polycystic Liver Disease

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Hepatic Cyst Infection Following Aspiration Sclerotherapy: a Case Series

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