Hepatic disorders associated with exogenous sex steroids: MR imaging findings

Hui, Cathryn; Lee, Zhen Jiang

doi:10.1007/s00261-019-01941-4

Cited by 10 publications

(8 citation statements)

References 39 publications

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“…However, other studies report that surgery should be reserved for cases where hemorrhage is life-threatening [12]. In cases caused by some specifi c drug intake, a total regression was noticed after the interruption of the treatment, which reinforces the indication of conservative management [12][13][14][15]23].…”

Section: Discussionmentioning

confidence: 96%

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Gottron’s acrogeria and peliosis hepatis

Ramirez¹,

Rodriguez²,

Garcia³

et al. 2019

Glob J Rare Dis

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We report the case of a 62-year-old woman with Gottron's acrogeria and peliosis hepatis. Gottron's acrogeria is a rare congenital disease characterized by atrophic acral skin with mottled hyperpigmentation and an aged appearance. It is mostly caused by a mutation in COL3A1 gene that leads to defective production of type III collagen. These abnormalities in collagen produce fragility in different organs such as blood vessels, causing multiple vascular disorders, which would include peliosis hepatis. Peliosis hepatis is a pathological condition with multiple blood-fi lled lacunar lesions within the hepatic parenchyma. It is induced by several mechanisms, from chronic debilitating conditions to infections or immunocompromised status, standing out long-term oral contraceptive therapies, which our patient had taken for fi fteen years. Peliosis hepatis lesions tend to regress after cessation of estrogen treatment, but our patient developed the vascular disorder eighteen years after ending the therapy, with no evidence of peliosis in previous radiological tests. We suggest that peliosis is related to collagen defects caused by Gottron's acrogeria. No previously known associations between these entities were found despite exhaustive investigations.

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Section: Discussionmentioning

confidence: 96%

“…Peliosis hepatis (PH) is a very rare disease characterized by multiple, small, blood-fi lled cysts within the liver [8]. and iron chelating agents are also described [8,[12][13][14][15].…”

Section: Discussionmentioning

confidence: 99%

Gottron’s acrogeria and peliosis hepatis

Ramirez¹,

Rodriguez²,

Garcia³

et al. 2019

Glob J Rare Dis

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“…Data are limited regarding the prevalence of STI among individuals with neo-organs (final organ structure based on a surgical procedure, such as a neovagina in transwomen). Furthermore, those status postvaginoplasty with integrated intestinal grafts carry a risk for inflammatory bowel diseases (IBD) and malignancy, as discussed further (27,28).…”

Section: Bowel Disordersmentioning

confidence: 99%

“…Hepatic vascular lesions have also been documented in patients on exogenous steroids (87). Peliosis hepatis is a rare vascular lesion that is characterized by formation of sinusoidal dilatation and blood-filled hepatic spaces (28). Cases of peliosis hepatis have been reported in cisgender women on OCP and in cisgender men on anabolic steroids (88).…”

Section: Hepatic Adenomas and Vascular Disordersmentioning

confidence: 99%

Digestive Health in Sexual and Gender Minority Populations

et al. 2022

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It has been over 50 years since the Stonewall Inn Riots in June 1969, a seminal event for the lesbian, gay, bisexual, transgender, queer, intersex, and other sexual and gender-diverse minorities (LGBTQI1, or lesbian, gay, bisexual, transgender, queer, intersex, and everyone else) rights movement. However, sexual and gender minority (SGM) individuals still face discrimination and harassment due to their sexual orientation or gender identity. As such, the National Institute on Minority Health and Health Disparities has identified SGM communities as a "health disparity population." Broadly, there are higher rates of sexually transmitted infections, substance use and abuse, mental health conditions, obesity and eating disorders, certain cancers (breast, cervical, and anorectal), and cardiovascular disease in SGM communities. Transgender patients, especially those of color, are more likely to be uninsured, experience discrimination, and be denied health care than cisgender patients. In addition, SGM individuals have twice the risk of lifetime exposure to emotional, physical, and sexual trauma compared with heterosexuals. It is expected all these factors would negatively affect digestive health as well. This review summarizes the effects of social determinants of health and discrimination on health care access, highlights important digestive diseases to consider in the SGM population, and offers solutions to improve and prioritize the health of these communities. We aim to draw attention to SGM-specific issues that affect gastrointestinal health and spur research that is desperately lacking.

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“…The condition has been reported not only in use of 17-alpha-alkylated steroids, but also in patients treated with unmodified testosterone[ 19 ]. Given its benign nature, most cases of peliosis hepatis are incidentally found and the most appropriate diagnostic modalities are magnetic resonance imaging[ 55 ] and histological examination. Once diagnosed, the offending drug should be discontinued and the condition closely monitored to reduce the risk of rupture, especially with larger lesions.…”

Section: Peliosis Hepatismentioning

confidence: 99%

Anabolic androgenic steroid-induced liver injury: An update

Petrovic¹,

Vukadin²,

Sikora³

et al. 2022

WJG

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Anabolic androgenic steroids (AASs) are a group of molecules including endogenous testosterone and synthetic derivatives that have both androgenic and anabolic effects. These properties make them therapeutically beneficial in medical conditions such as hypogonadism. However, they are commonly bought illegally and misused for their anabolic, skeletal muscle building, and performance-enhancing effects. Supraphysiologic and long-term use of AASs affects all organs, leading to cardiovascular, neurological, endocrine, gastrointestinal, renal, and hematologic disorders. Hepatotoxicity is one of the major concerns regarding AASs treatment and abuse. Testosterone and its derivatives have been most often shown to induce a specific form of cholestasis, peliosis hepatis, and hepatic benign and malignant tumors. It is currently believed that mechanisms of pathogenesis of these disorders include disturbance of antioxidative factors, upregulation of bile acid synthesis, and induction of hepatocyte hyperplasia. Most toxicity cases are treated with supportive measures and liver function normalizes with discontinuation of AAS. However, some long-term consequences are irreversible. AAS-induced liver injury should be taken in consideration in patients with liver disorders, especially with the increasing unintentional ingestion of supplements containing AAS. In this paper, we review the most current knowledge about AAS-associated adverse effects on the liver, and their clinical presentations, prevalence, and pathophysiological mechanisms.

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Hepatic disorders associated with exogenous sex steroids: MR imaging findings

Cited by 10 publications

References 39 publications

Gottron’s acrogeria and peliosis hepatis

Gottron’s acrogeria and peliosis hepatis

Digestive Health in Sexual and Gender Minority Populations

Anabolic androgenic steroid-induced liver injury: An update

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