Hepatic epithelioid hemangioendothelioma: a report from three university centers

Giardino, Antonello; Miller, Frank H.; Kalb, Bobby; Ramalho, Miguel; Martín, Diego R.; Rodacki, Karina; Woosley, John T.; Semelka, Richard C.

doi:10.1590/0100-3984.2015.0059

Cited by 23 publications

(24 citation statements)

References 24 publications

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“…We prospectively analyzed 100 consecutive CT angiography examinations of the abdomen performed at the General Hospital of Fortaleza over a one-year period. The imaging evaluation of the rhino-orbital region has been the object of a series of recent publications in the radiology literature of Brazil 24 - 29 .…”

Section: Discussionmentioning

confidence: 99%

Computed tomography angiography study of variations of the celiac trunk and hepatic artery in 100 patients

et al. 2018

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Objective To describe the main anatomical variations of the celiac trunk and the hepatic artery at their origins.Materials and Methods This was a prospective analysis of 100 consecutive computed tomography angiography studies of the abdomen performed during a one-year period. The findings were stratified according to classification systems devised by Sureka et al. and Michels.Results The celiac trunk was "normal" (i.e., the hepatogastrosplenic trunk and superior mesenteric artery originating separately from the abdominal aorta) in 43 patients. In our sample, we identified four types of variations of the celiac trunk. Regarding the hepatic artery, a normal anatomical pattern (i.e., the proper hepatic artery being a continuation of the common hepatic artery and bifurcating into the right and left hepatic arteries) was seen in 82 patients. We observed six types of variations of the hepatic artery.Conclusion We found rates of variations of the hepatic artery that are different from those reported in the literature. Our findings underscore the need for proper knowledge and awareness of these anatomical variations, which can facilitate their recognition and inform decisions regarding the planning of surgical procedures, in order to avoid iatrogenic intraoperative injuries, which could lead to complications.

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Section: Discussionmentioning

confidence: 99%

Computed tomography angiography study of variations of the celiac trunk and hepatic artery in 100 patients

et al. 2018

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“…Mean age at presentation has ranged between 30 and 40 years. In Giardino et al’s series of 7 cases also, mean age was 47 years [ 8 ]. They are rare in children and show a slight predilection for females.…”

Section: Discussionmentioning

confidence: 99%

“…They are rare in children and show a slight predilection for females. However, 6 out of 7 patients in the series reported by Giardino et al were females [ 8 ]. In our series also, a slight predilection for females was seen (4 out 7) and 3 out of 7 patients (42.9%) were asymptomatic at the time of diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Hepatic epithelioid hemangioendothelioma: case series of a rare vascular tumor mimicking metastases

Din¹,

Rahim²,

Asghari³

et al. 2020

Diagn Pathol

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Background Hepatic epithelioid hemangioendothelioma is an extremely rare malignant vascular tumor which is often multifocal and, in many cases, discovered incidentally. Here, we describe the clinicopathological features of hepatic epithelioid hemangioendothelioma cases seen in our practice and present a detailed review of the published literature. Methods All cases of hepatic epithelioid hemangioendothelioma diagnosed in Department of Pathology and Laboratory Medicine, Aga Khan University Hospital between January 1, 2006 and December 31, 2019 were included in the study. Slides were reviewed and follow up was obtained. Results Seven cases were reported during the study period. There were 4 females and 3 males. Age range was 20 to 77 years, mean age was 45 years. Three patients presented with right upper abdominal pain; 1 patient presented with jaundice while 3 patients were asymptomatic. In all 7 cases, lesions were identified on imaging studies. In 5 cases, liver lesions were multifocal. Clinical differential diagnosis in all cases was metastatic carcinoma and multifocal hepatocellular carcinoma. Liver function tests were normal in 5 cases. In 1 patient, tumor had already metastasized to the right lung. On histological examination of liver core biopsies performed in all 7 cases, classic histological features of epithelioid hemangioendothelioma were seen. Tumor cells expressed positivity for vascular markers (CD 34, CD31 and ERG) and were negative for cytokeratins, Hep par 1 and Glypican 3. Surgical resection was not performed in any of the 7 cases and all patients were treated by chemotherapy. Follow up was available in 5 cases. Of these, 3 patients died of disease and another patient was alive with metastases in both lungs, omentum and colon. Conclusion Clinicopathological features of the 7 cases in our series and detailed review of published literature is presented. Prognosis was bad in our cases most likely due to fact that surgical resection could not be performed in any of the cases owing to lack of surgical expertise for liver tumor surgery in most parts of the country.

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“…Продолжительность клинических проявлений до установки диагноза варьирует от 3 мес до 2 лет. Лабораторные исследования показывают, что ферменты печени могут быть умеренно повышены, но уровни опухолевых маркеров (альфа-фетопротеин, канцероэмбриональный антиген) остаются в норме [7,8].…”

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“…При иммуногистохимических реакциях в опухолевых клетках отмечается экспрессия фактора фон Виллебранда, СD31, CD34, виментина, ламинина [8,10] (рис. 1).…”

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