Hepatic Failure as the Presenting Manifestation of Malignant Lymphoma

Thompson, D. R.; Faust, Thomas W.; Stone, Marvin J.; Polter, Daniel E.

doi:10.3816/clm.2001.n.018

Cited by 36 publications

(25 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Hodgkin and non-Hodgkin lymphomas, acute leukemias, and transformation of chronic leukemias to acute stages have all been associated with sporadic cases of acute liver failure [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] . The important step in the diagnosis of such pathologies is a liver biopsy once other obstructive, toxic, and infective causes of liver failure have been ruled out by laboratory tests and imaging studies.…”

Section: Discussionmentioning

confidence: 99%

Acute Liver Failure Because of Chronic Lymphocytic Leukemia: Case Report and Review of the Literature

et al. 2011

View full text Add to dashboard Cite

Infiltration of the liver by hematologic malignancies is an uncommon cause of liver failure. B-Cell chronic lymphocytic leukemia (CLL) is a usually indolent disease that may infiltrate the liver, but based on a review of the literature, has never been reported to induce acute liver failure. Here, we describe the case of a 78-year-old woman with acute liver failure secondary to infiltration with CLL being unresponsive to chemotherapy and causing death. This case is notable because of its atypical presentation and ultimate poor prognosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Acute Liver Failure Because of Chronic Lymphocytic Leukemia: Case Report and Review of the Literature

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Tanısal amaçlı karaci¤erden Core (kor) biyopsi yapılması önerilmektedir. [7] Çünkü perkütan biyopsi ile %10'dan daha az bir oranda tanı konulmakta olup bunun nedeni, Reed-Sternberg hücrelerinin karaci¤erde yama eklinde düzen-siz da¤ılmı olmalarıdır. [7] Perkütan biyopsi ile yeterli örnek alınamamaktadır.…”

Section: Tartimaunclassified

“…[7] Çünkü perkütan biyopsi ile %10'dan daha az bir oranda tanı konulmakta olup bunun nedeni, Reed-Sternberg hücrelerinin karaci¤erde yama eklinde düzen-siz da¤ılmı olmalarıdır. [7] Perkütan biyopsi ile yeterli örnek alınamamaktadır. Bu olguda postmortem uyguladı¤ımız perkütan karaci¤er biyopsisi sonucunda submasif nekroz saptandı ve bu nedenle Reed-Sternberg hücreleri gözle-nemedi.…”

Section: Tartimaunclassified

Fulminant hepatic failure presented with Hodgkin lymphoma

Akarken¹

2017

FNG & Bilim Tıp Dergisi

View full text Add to dashboard Cite

Fulminant hepatic disease has an aggressive nature with a high mortality rate. Viral hepatitis is in the first place among its causes. Other than this, liver failure may rarely occur in lymphoma patients. The prevalence of liver failure in Hodgkin's lymphoma is lower than that of non-Hodgkin's lymphoma. In this report, we present a 44-year-old male patient with liver failure who was diagnosed as Hodgkin lymphoma during the postmortem examination. Fulminan hepatik yetmezlik (FHY), akut karaci¤er yetmezli¤i olarak da adlandırılır. Seyrek görülmesinin yanı sıra agresif seyirli ve kötü prognozlu bir hastalıktır. Sarılık balangıcını takiben hepatik ensefalopatinin ortaya çıkma süresine göre sınıflandırılır. Bir haftadan az bir sürede geliiyorsa "hiperakut", 8-28 gün arasında ise "akut", 5-12 hafta arasında ise "subakut" karaci¤er yetmezli¤i terimleri kullanılır.[1] Etyolojide ön planda viral ve toksik hepatitler olmasına karın nadiren lenfoma ve lösemilere sekonder de geliebilir. Bu yazıda nedeni bilinmeyen ate ile takip edilirken akut karaci¤er yetmezli¤i gelien ve hodgkin lenfoma tanısı konulan bir erkek hasta sunuldu. OLGU SUNUMUKuyumculuk ile u¤raan ve son 1.5 aydır devam eden ate, üüme, titreme yakınması ile dahiliye poliklini¤ine bavuran 44 yaındaki erkek hastanın öyküsünden, herhangi bir kronik hastalı¤ı ve ilaç kullanım öyküsü olmadı¤ı, bir yıl önce menengiom nedeniyle ameliyat oldu¤u, beyin parankiminin normal oldu¤u ve invazyonu olmadı¤ı ö¤renildi. ‹leri derecede halsizlik, itahsızlık ve yaklaık 4-5 kg/ay kilo kaybı vardı. Hayvanlarla veya la¤ım ile temas öyküsü yoktu. Pastörize edilmemi süt ürünü kullanmıyordu. Fizik muayenesinde; tansiyon ve nabız normaldi. Ate gün içinde en yüksek 38.5 °C ölçüldü. Cildi sarı ve nemli görünümde idi ve sistemik lenf nodu muayenesinde ele gelen lenf nodu yoktu. Batın muayenesinde; karaci¤er kaburga altında 2 cm palpe ediliyordu. Bilinci açık, oryantasyon, kooperasyon ve di¤er sistem muayeneleri ola¤andı. Laboratuvar de¤erlerinde; Açlık glukoz: 116 mg/dL, üre: 46 mg/dL, kreatinin: 1.2 mg/dL, AST: 236 U/L, ALT: 91U/L, Na: 126 mmol/L, total bilirubin: 4.3 mg/dL, direct bilirubin: 2.6 mg/dL, hemoglobin: 9.2 gr/dL,

show abstract

“…[13][14][15][16] Rowbotham et al reported a 0.45% incidence of acute liver failure associated with malignant lymphoma, 5 and onset of lymphoma in association with acute hepatitis has also been reported. [5][6][7][8][9][10][11] In our patient, findings of tumor cell invasion in hepatic tissue suggested liver injury by the tumor cells, while findings of hemophagocytosis on bone marrow examination and high ferritin levels suggested that the liver injury was also related to HPS.…”

mentioning

confidence: 94%

“…In primary hepatic malignant lymphoma, the diagnosis is even more difficult than in our case, and taking a patient's general condition into consideration, urgent liver biopsy is important for diagnosis and treatment. [5][6][7][8][9][10][11] Malignant lymphoma, either hepatic primary or secondary, must be considered as a cause of acute liver failure.…”

mentioning

confidence: 99%

A case of peripheral T-cell lymphoma presenting with acute liver failure

Konno

Takahashi

Watanabe

et al. 2011

Clin J Gastroenterol

View full text Add to dashboard Cite

A 68-year-old woman was evaluated by her primary physician for swelling and pain in the right neck. Treatment with antibiotics failed to achieve any improvement. Two weeks later, she was hospitalized to the gastroenterology service because of liver dysfunction and pneumonia. Disseminated intravascular coagulation (DIC) was diagnosed, and protease inhibitor and steroid pulse therapy were started. She was transferred to our department for further evaluation the following day. Bone marrow examination revealed hemophagocytosis and infiltration of CD3-positive cells. Multiple masses were identified in the liver. Her prothrombin time was 35.7% of the standard value 17 days from disease onset, despite improvement of DIC. She was diagnosed with acute liver failure based on the Japanese diagnostic criteria. Her general condition worsened quickly, which prevented use of chemotherapy, and she died after a total course of 19 days. Autopsy revealed atypical lymphocytes in the liver. The diagnosis was peripheral T-cell lymphoma.

show abstract

Hepatic Failure as the Presenting Manifestation of Malignant Lymphoma

Cited by 36 publications

References 26 publications

Acute Liver Failure Because of Chronic Lymphocytic Leukemia: Case Report and Review of the Literature

Acute Liver Failure Because of Chronic Lymphocytic Leukemia: Case Report and Review of the Literature

Fulminant hepatic failure presented with Hodgkin lymphoma

A case of peripheral T-cell lymphoma presenting with acute liver failure

Contact Info

Product

Resources

About