Hepatic Fat Content and Liver Enzymes Are Associated with Circulating Free and Protein-Bound Advanced Glycation End Products, Which Are Associated with Low-Grade Inflammation: The CODAM Study

Bijnen, Mitchell; Greevenbroek, Marleen M.J. van; Kallen, Carla; Scheijen, Jean L.J.M.; Waarenburg, Marjo P. H. van de; Stehouwer, Coen D. A.; Wouters, Kristiaan; Schalkwijk, Casper G.

doi:10.1155/2019/6289831

Cited by 12 publications

(12 citation statements)

References 40 publications

(59 reference statements)

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“…N‐epsilon‐(carboxymethyl) lysine is a major component of advanced glycation end products (AGEs), which is a heterogeneous group of molecules formed by the nonenzymatic reaction of reducing sugars with the amino group of proteins, lipids, and nucleic acids . Soluble receptor for AGE (sRAGE) binds with AGEs as a competing factor for RAGE, and sRAGE consists of both cleaved RAGE (cRAGE) and endogenous secretory RAGE (esRAGE) which circulate in the blood .…”

Section: Discussionmentioning

confidence: 99%

Middle‐ and high‐molecular weight adiponectin levels in relation to nonalcoholic fatty liver disease

Lian

Feng

et al. 2019

Clinical Laboratory Analysis

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Objective: Adiponectin (APN) circulates as high-molecular weight (HMW), mediummolecular weight (MMW), and low-molecular weight (LMW) forms. Nonalcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease. Currently, the role of LMW, MMW, and HMW APN remains largely unclear in NAFLD. Methods:We examined the variation of these forms and analyzed the related clinical characteristics in NAFLD. A total of 63 male NAFLD patients (mean age: 43.00 ± 6.10 years) and 70 healthy male subjects (mean age: 42.53 ± 7.98 years) were included in the study.Total APN and other clinical characteristics were measured. The changes in HMW, MMW, and LMW APN were determined in NAFLD patients and NAFLD patients on a high-fat diet, and the association between the groups was further analyzed.Results: Decreased levels of total APN and three APN isoforms were found in NAFLD. Significantly decreased levels of HMW (P < .01) and MMW (P < .001) were observed in NAFLD of high-fat diet patients. In NAFLD patients, height (R = −.270, P = .032) and N-epsilon-(carboxymethyl) lysine (R = −.259, P = .040) significantly correlated with total APN. HMW APN was significantly associated with fasting plasma glucose (R = .350, P = .016), alanine aminotransferase (R = −.321, P = .029), and aspartate aminotransferase (R = −.295, P = .045). Additionally, MMW APN was significantly associated with total cholesterol (R = .357, P = .014) and high-density lipoprotein (R = .556, P < .0001). Low-density lipoprotein (R = −.283, P = .054) was also clearly associated with LMW APN in NAFLD patients. Conclusion: These results suggest that HMW and MMW APN may be involved in the pathogenesis and progression of NAFLD. K E Y W O R D S adiponectin, high-molecular weight, low-molecular weight, middle-molecular weight, nonalcoholic fatty liver disease

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Section: Discussionmentioning

confidence: 99%

Middle‐ and high‐molecular weight adiponectin levels in relation to nonalcoholic fatty liver disease

Lian

Feng

et al. 2019

Clinical Laboratory Analysis

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“…The increased formation of amadori product and advanced glycation end product leads to direct inflammation in liver by various types of signaling pathways( (Hyogo & Yamagishi, 2008) (Bijnen et al, 2019)). HMF is also responsible for the mutation of important gene in liver .…”

Section: Discussionmentioning

confidence: 99%

Nutritive diet becomes unhealthy if taken in a wrong ratio: Scientific validation of Ayurvedic concept of “incompatible diet” (Virrudh Aahar)

Aditi

Srivastava

Pandey

et al. 2019

Preprint

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AbstractHoney and ghee is an important constituent of our diet. Honey contain about 200 components in its which play an important role as antioxidative, anti-inflammatory, antimicrobial, wound healing and sunburn, etc. Ghee has also many essential constituents such as phospholipids, PUFA, fat- soluble vitamins, etc. It is mention in Charak Samhita that equal ratio of honey and ghee when taken in food become toxic to health. This study was designed to explore the mechanism of toxicity through the biochemical and histological parameter. For this study, 24 Charles foster rats were taken and divided into four groups (n=6) normal, honey, ghee, and honey+ghee (1:1). After 60 days rats were sacrificed. Weight loss, Hair loss and red patches on ear were found on honey+ghee fed rats. LFT, amadori test, AGE, UV, glucose, DPP-4 and LPO were found significantly increased in honey+ghee group. SOD, Catalase, GSH, ABTS+, GLP-1, GIP-1, ACB and HB were found significantly decreased in honey+ghee group. No changes were found in RFT. H&E show normal morphology in kidney, intestine, and pancreas but mild inflammation was found in liver tissue. We conclude that the equal mixture of honey and ghee shows toxic effect. Increased formation of hydroxymethyl furfural, amadori product, DPP-4 activity and low incretins (GLP-1, GIP-1) activity resulting high postprandial hyperglycemic response are collectively responsible for oxidative stress-mediated toxicity of the mixture of honey and ghee in equal ratio.

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“…Studies included in the systematic review reported data on 1844 participants (909 with NAFLD, 169 with ALD and 766 healthy controls). Three studies focused on ALD [37][38][39] and eight studies on NAFLD [29][30][31][32][33][34][35][36]. In studies on ALD, the diagnosis was confirmed with a biopsy.…”

Section: Systematic Reviewmentioning

confidence: 99%

“…The number of studies obtained for each comparison was too small to assess publication bias using statistical methods such as Egger's test. [30,32,34,36].…”

Section: Meta-analysismentioning

confidence: 99%

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Advanced Glycation End-Products in Common Non-Infectious Liver Diseases: Systematic Review and Meta-Analysis

2021

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Background: Excessive intake of fructose, glucose and alcohol is associated with the development of non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD). At the same time, these dietetic factors create an environment favorable for the generation of advanced glycation end-products. For this reason, advanced glycation end-products (AGEs) are hypothesized to play role in the development of NAFLD and ALD. In this systematic review and meta-analysis, we explore the relationship between NAFLD and ALD with AGE levels, including their diagnostic accuracy. Methods: The systematic review and meta-analysis has been pre-registered with PROSPERO (CRD42021240954) and was performed in accordance with the PRISMA guidelines. Meta-analyses were performed using the meta R package. Results: We have obtained 11 studies meeting our inclusion criteria, reporting data on 1844 participants (909 with NAFLD, 169 with ALD and 766 healthy controls). NAFLD was associated with significantly higher AGE fluorescence and serum N-(carboxyethyl)lysine (CEL) levels. Patients with alcoholic cirrhosis had significantly higher levels of N-(carboxymethyl)lysine (CML). Only individual studies examined AGEs in the context of their diagnostic accuracy. AGE fluorescence distinguished low and moderate steatosis with an AUC of 0.76. The ratio of CML, CEL and pentosidine to a soluble variant of the AGE receptor differentiated patients with NAFLD from healthy controls with high AUC (0.83–0.85). Glyceraldehyde-derived AGE separated non-alcoholic fatty liver (NAFL) from non-alcoholic steatohepatitis (NASH) with acceptable performance (AUC 0.78). Conclusions: In conclusion, NAFLD and ALD are associated with significantly higher levels of several AGEs. More research is needed to examine the diagnostic accuracy of AGEs, however individual studies show that AGEs perform well in distinguishing NAFL from NASH.

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Hepatic Fat Content and Liver Enzymes Are Associated with Circulating Free and Protein-Bound Advanced Glycation End Products, Which Are Associated with Low-Grade Inflammation: The CODAM Study

Cited by 12 publications

References 40 publications

Middle‐ and high‐molecular weight adiponectin levels in relation to nonalcoholic fatty liver disease

Middle‐ and high‐molecular weight adiponectin levels in relation to nonalcoholic fatty liver disease

Nutritive diet becomes unhealthy if taken in a wrong ratio: Scientific validation of Ayurvedic concept of “incompatible diet” (Virrudh Aahar)

Advanced Glycation End-Products in Common Non-Infectious Liver Diseases: Systematic Review and Meta-Analysis

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