Hepatic Function and its Association with Clinical Outcomes in Non-Adherent HIV-1 Adults ‎‎

Abstract

Results: Levels of total protein and globulin were elevated among HAART non-adherent participants relative to HAART adherent participants. Furthermore, Albumin to total protein and albumin to globulin ratios were lower in the HAART non-adherent participants relative to the HAART adherent group. CD4+ counts positively correlated with globulin levels. However, levels of Aspartate transaminase, Alanine transaminase, Alkaline phosphatase and Gamma glutamyl transferase were similar between HAART non-adherent and HAART adherent participants. Conclusion:Non-adherence to HAART dysregulates hepatic globulin synthesis without significant hepatic damage .