Hepatic Hemodynamic Changes Following Stepwise Liver Resection

Golriz, Mohammad; Sakka, Saroa El; Majlesara, Ali; Edalatpour, A.; Hafezi, Mohammadreza; Rezaei, Nahid; Garoussi, Camelia; Arwin, Jalal; Saffari, Arash; Raisi, H; Abbasi, Arezou; Mehrabi, Arianeb

doi:10.1007/s11605-015-3021-y

Cited by 23 publications

(31 citation statements)

References 37 publications

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“…In animal liver resection experiments, a hepatic arterial flow and pressuree decrease was observed due to blood loss; eg, 75% pig's liver ablation was reported to cause an average decrease (ranging from 50.0% to 87.0% in 12 pigs) of hepatic artery flow generally proportional to the liver mass removed . A similar reduced postoperative hepatic arterial flow was observed in 25% swine liver resection . A decreased postoperative hepatic arterial flow was also experienced in rats .…”

Section: Introductionsupporting

confidence: 74%

“…The postoperative pressure also relates to the extent of resection. For example, while no significant change of hepatic artery pressure was reported in Golriz et al after 25% of liver resection in pigs, the postoperative pressure decreased when more than half of the liver lobe was removed.…”

Section: Introductionmentioning

confidence: 78%

“…Therefore, it should be kept in mind that both methods are informative and need to be further validated. The hepatic artery in human liver has complicated intersubject variation, and postoperative hepatic perfusion also shows intersubject variation, as observed in animal experiments . Additionally, the postoperative hepatic perfusion relates to the extent of partial hepatectomy in an individual subject.…”

Section: Discussionmentioning

confidence: 94%

“…The hepatic artery in human liver has complicated intersubject variation, and postoperative hepatic perfusion also shows intersubject variation, as observed in animal experiments. 16,17 Additionally, the postoperative hepatic perfusion relates to the extent of partial hepatectomy in an individual subject. A quantitative study in the future will be useful to validate the proposed model further when more comprehensive clinical data of more subjects become available.…”

Section: Discussionmentioning

confidence: 99%

“…16 A similar reduced postoperative hepatic arterial flow was observed in 25% swine liver resection. 17 A decreased postoperative hepatic arterial flow was also experienced in rats. 18 Large intersubject variability of postoperative hepatic artery pressure measurements was reported in animal experiments in the literature, eg, 16 observed both increased and decreased postoperative pressure after 75% of pig liver resection.…”

Section: Introductionmentioning

confidence: 95%

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Modeling the hepatic arterial flow in living liver donor after left hepatectomy and postoperative boundary condition exploration

Hunter

Cousins³

et al. 2019

Numer Methods Biomed Eng

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Preoperative and postoperative hepatic perfusion is modeled with one‐dimensional (1‐D) Navier‐Stokes equations. Flow rates obtained from ultrasound (US) data and impedance resulted from structured trees are the inflow and outflow boundary condition (BC), respectively. Structured trees terminate at the size of the arterioles, which can enlarge their size after hepatectomy. In clinical studies, the resistance to pulsatile arterial flow caused by the microvascular bed can be reflected by the resistive index (RI), a frequently used index in assessing arterial resistance. This study uses the RI in a novel manner to conveniently obtain the postoperative outflow impedance from the preoperative impedance. The major emphasis of this study is to devise a model to capture the postoperative hepatic hemodynamics after left hepatectomy. To study this, we build a hepatic network model and analyze its behavior under four different outflow impedance: (a) the same as preoperative impedance; (b) evaluated using the RI and preoperative impedance; (c) computed from structured tree BC with increased radius of terminal vessels; and (d) evaluated using structured tree with both increased radius of root vessel, ie, the outlets of the postoperative hepatic artery, and increased radius of terminal vessels. Our results show that both impedance from (b) and (d) give a physiologically reasonable postoperative hepatic pressure range, while the RI in (b) allows for a fast approximation of postoperative impedance. Since hemodynamics after hepatectomy are not fully understood, the methods used in this study to explore postoperative outflow BC are informative for future models exploring hemodynamic effects of partial hepatectomy.

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Section: Introductionsupporting

confidence: 74%

Section: Introductionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

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