Hepatic lipase activity after liver denervation in hypothyroid rats

Berg, Anna‐Lena; Hammarström, Lars-Erik; Hansson, Per; Holmin, T.; Nilsson‐Ehle, Peter

doi:10.1530/acta.0.1230090

Cited by 2 publications

(2 citation statements)

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“…Hepatic hilar denervation, which causes a total loss of the sympathetic and vagal reflexes, results in a 90% drop of norepinephrine concentration in the liver (Berg et al, 1990; Kato et al, 1996; Carlson et al, 1998). Hepatic vagotomy alone does not have any effect on the hepatic norepinephrine concentrations (Berg et al, 1990).…”

Section: Effect Of Hepatic Denervation In Experimental Animal Modelsmentioning

confidence: 99%

Transplanted liver: Consequences of denervation for liver functions

et al. 2004

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Following liver transplantation, all hepatic nerves are transected; thus, liver allografts are completely isolated from neural control of their hosts. Despite this absolute denervation, liver allograft function does not appear to be significantly impaired after successful transplantation. In experimental animal models, hepatic denervation has no major effects on bile acid production and biotransformation, while it increases blood pressure and salt retention; decreases the number of hepatic progenitor cells, cholangiocyte proliferation, and liver regeneration; and influences the hepatic microcirculation, diet behavior, and glycemic control. In humans, hepatic denervation after liver transplantation has no major deleterious effects on bile secretion, liver regeneration, and hepatic blood flow. Insulin resistance and postprandial hyperglycemia, changes in ingestion behavior, and reduced stimulation of hepatic progenitor cells in the canals of Hering are the major side effects of absent liver innervation. Despite these abnormalities, patients can lead a new life with improved quality of life. © 2004 Wiley-Liss, Inc. Key words: liver transplantation; denervation; function; hepaticLiver transplantation is the ultimate treatment for patients with acute fulminant and chronic liver failure. The results of liver transplantation are good, with a 1-year survival of 90 -95% and a 10-year survival of 50 -60%. Because of a shortage in cadaveric donors, living-related liver transplantation is a good option to overcome this problem.The autonomic nerves of the liver are formed by an anterior plexus (around the hepatic artery) and a posterior plexus (surrounds portal vein and bile duct). Parasympathetic nerves are derived from the vagus nerve and the sympathetic fibers from the celiac ganglion. Sensory nerve endings are present in the liver capsule, central veins, and bile ducts. Most of the afferent nerves from the liver run via the vagus and splanchnic nerves, but some also to the right phrenic nerve. The afferent nerves register information from nocireceptors, osmo-and baroreceptors, as well as ionic and metabolic receptors (Bathal and Grossman, 1999).Following liver transplantation, the hepatic nerves are inevitably transected below the porta hepatis or at the hepatoduodenal ligament; thus, liver allografts are completely isolated from the neural control of their hosts. Despite this absolute denervation, the liver allograft does not appear to be significantly compromised after successful transplantation. There is no obvious deficiency in the regulation of liver metabolism (production of proteins such as albumin and coagulation factors, metabolization) and bile production. At first blush, it seems that under normal circumstances, hormones and substrates reaching the liver by circulation are responsible for control of the organ function, and that the role of hepatic nerves is mainly restricted to situations of physiological stress.However, a more profound search revealed that hepatic denervation has a lot of consequences...

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Section: Effect Of Hepatic Denervation In Experimental Animal Modelsmentioning

confidence: 99%

Transplanted liver: Consequences of denervation for liver functions

et al. 2004

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“…Berg and colleagues were the fi rst to report that adrenocorticotropic hormone (ACTH) lowered albumin excretion and improved glomerular fi ltration rate (GFR) in patients with membranous nephropathy, 7,8 in steroid-treated patients with renal disease, 9 and in patients on hemodialysis. 10 Almost all participants in these studies had a reduction in serum low-density lipoprotein (LDL) cholesterol and lipoprotein(a), whereas the infl uence of the agent on triglyceride metabolism was less consistent.…”

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confidence: 99%

Membranous Nephropathy: ACTH Shows Promise

Fervenza¹

2012

Nephrology Times

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Hepatic lipase activity after liver denervation in hypothyroid rats

Cited by 2 publications

References 19 publications

Transplanted liver: Consequences of denervation for liver functions

Transplanted liver: Consequences of denervation for liver functions

Membranous Nephropathy: ACTH Shows Promise

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