Hepatically derived selenoprotein P is a key factor for kidney but not for brain selenium supply

Schweizer, Ulrich; Streckfuß, F.; Pelt, Paco; Carlson, Bradley A.; Hatfield, Dolph L.; Köhrle, Josef; Schomburg, Lutz

doi:10.1042/bj20041973

Cited by 190 publications

(179 citation statements)

References 34 publications

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“…Indeed, the MDA yield depends on the concentration of PUFA in the analysed tissues (Del Rio et al, 2005;Czauderna et al, 2011b;). Moreover, the presence of antioxidants (like Se-compounds or tocopherols) can reduce MDA formation in animals and humans (Schweizer et al, 2005;Czauderna et al, 2011b). According to the above and all of the results summarized in Table 6, we argue that our proposed original MDA index (calculated as: MDA index = (MDA+PUFA)/PUFA); Table 6) is the best indicator of the yield of PUFA peroxidation in tissues of living organisms.…”

Section: Effect Of the Experimental Rations On The Yield Of Pufa Peromentioning

confidence: 71%

“…Indeed, recent studies support the concept that the pro-oxidative effect of diets with higher concentrations of inorganic chemical forms of Se-compounds (selenate, selenite, or selenide) is due to the catalysis of hydrosulphide oxidation that results in an inhibitory effect on protein biosynthesis (Navarro-Alarcon and Cabrera-Vique, 2008). In contrast to dietary selenate or selenite, Se-Met, the main Se-compound in dietary SeY (Rayman, 2004), is less reactive, and because tRNAMet does not discriminate between Se-Met and methionine, dietary Se-Met from SeY is incorporated into body protein in place of methionine (Tapiero et al, 2003;Schweizer et al, 2005;Weiss and Hogan, 2005). Se-Met as a Se-Met residue in general proteins is a stable and safe storage mode for Se in the body of animals and humans (Rayman, 2004).…”

Section: Influence Of the Experimental Rations On Performance Parametmentioning

confidence: 99%

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Dietary lycopenes, selenium compounds and fish oil affect the profile of fatty acids and oxidative stress in chicken breast muscle

et al. 2012

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The aim of the study was to determine the influence of the addition for 6 weeks of 12 ppm lycopene (Lyc), 2% fish oil (FO) and/or 0.25 ppm Se as selenate (Se VI ) or selenized yeast (SeY) to an isoenergetic and isonitrogenous basal ration containing sunflower oil (SO) as the source of energy on the liveweight (LW) and feed intake per kg body weight gain of pullets and cockerels. The effects of these additives on the concentrations of fatty acids (FA), especially mono-(MUFA) and polyunsaturated (PUFA) acids, and the yield of PUFA peroxidation (oxidative stress) in breast muscles of chickens were also investigated. Feeding broilers with the experimental rations slightly increased the live body weight of chickens compared with the controls. The ration containing SeY, Lyc, and FO most effectively increased the LW of cockerels, while that of pullets was most efficiently increased by the ration enriched in SeY and Lyc, irrespective of the presence of extra FO. SeY in the ration with Lyc most efficiently elevated feed conversion efficiency (FCE), while Se VI in the ration containing Lyc most effectively decreased FCE. The addition of Se VI to the ration enriched in Lyc significantly elevated the sum of saturated fatty acids (SFA), MUFA, and PUFA in muscles of pullets and, especially, cockerels in comparison with all other examined groups. In contrast, FO added to the ration containing Lyc, irrespective of the presence of Se VI or SeY, decreased the muscle sum of SFA, MUFA, and PUFA, and increased the concentration of docosahexaenoic acid in muscles of chickens compared with the control and all other experimental groups. FO added to the ration, regardless of the presence of Se VI or SeY, elevated the value of the long-chain n-3 PUFAto-SFA ratio and significantly decreased the values of the n-6 PUFA/n-3 PUFA ratio in muscles of pullets and cockerels. The ration containing Lyc and Se VI most efficiently increased the value of the 3 Corresponding author: e-mail: m.czauderna@ifzz.pan.pl Journal of Animal and Feed Sciences, 21, 2012, 705-724 706 LYCOPENES AND Se COMPOUNDS -FA IN CHICKEN MUSCLE PUFA/SFA ratio in the muscles of pullets and, especially, cockerels. The ration containing FO and Lyc most significantly increased the accumulation of malondialdehyde (MDA) in muscles of pullets and, in particular, cockerels, while addition of Se VI or SeY to the ration enriched in FO and Lyc most considerably decreased the concentration of MDA in breast muscles compared with the control and all other experimental groups. We propose an MDA index (calculated as: MDAindex = (MDA+PUFA)/ PUFA) as an original indicator of PUFA peroxidation in tissues of living organisms.Our results of feeding diets with Lyc, FO, and Se as Se VI or SeY constitute useful information for nutritionists carrying out investigations to improve chicken performance and the nutritional quality of feed, as well as to improve the nutritive value of chicken meat from the aspect of human health.

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Section: Effect Of the Experimental Rations On The Yield Of Pufa Peromentioning

confidence: 71%

Section: Influence Of the Experimental Rations On Performance Parametmentioning

confidence: 99%

Dietary lycopenes, selenium compounds and fish oil affect the profile of fatty acids and oxidative stress in chicken breast muscle

et al. 2012

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“…Therefore, it is likely that Sepp1 transports selenium from brain cells that synthesize it (e.g., astrocytes) (Yang et al, 2000), to cells that express apoER2 (e.g., neurons). Such a selenium economy inside the blood-brain barrier might contribute to the ability of the brain to conserve its selenium (Schweizer et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Deletion of Apolipoprotein E Receptor-2 in Mice Lowers Brain Selenium and Causes Severe Neurological Dysfunction and Death When a Low-Selenium Diet Is Fed

Burk

Hill²,

Olson³

et al. 2007

Journal of Neuroscience

159

130

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Selenoprotein P (Sepp1) is a plasma and extracellular protein that is rich in selenium. Deletion of Sepp1 results in sharp decreases of selenium levels in the brain and testis with dysfunction of those organs. Deletion of Sepp1 also causes increased urinary selenium excretion, leading to moderate depletion of whole-body selenium. The lipoprotein receptor apolipoprotein E receptor-2 (apoER2) binds Sepp1 and facilitates its uptake by Sertoli cells, thus providing selenium for spermatogenesis. Experiments were performed to assess the effect of apoER2 on the concentration and function of selenium in the brain and on whole-body selenium. ApoER2 Ϫ/Ϫ and apoER2 ϩ/ϩ male mice were fed a semipurified diet with selenite added as the source of selenium. ApoER2 Ϫ/Ϫ mice had depressed brain and testis selenium, but normal levels in liver, kidney, muscle, and the whole body. Feeding a selenium-deficient diet to apoER2 Ϫ/Ϫ mice led to neurological dysfunction and death, with some of the characteristics exhibited by Sepp1 Ϫ/Ϫ mice fed the same diet. Thus, although it does not affect whole-body selenium, apoER2 is necessary for maintenance of brain selenium and for prevention of neurological dysfunction and death under conditions of selenium deficiency, suggesting an interaction of apoER2 with Sepp1 in the brain.

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“…Hepatocyte-specific inactivation of Trsp starts early during embryonic development and is complete by three weeks after birth (49). In a first report, these mice were shown to die prematurely of acute liver failure in conjunction with fat necrosis (49), while the mice were seemingly healthy in our lab up to at least 6 months of age (26). This discrepancy is now under investigation.…”

Section: Trna Secmentioning

confidence: 90%

New insights into the physiological actions of selenoproteins from genetically modified mice

Schweizer

Schomburg

2005

IUBMB Life (International Union of Biochemistry and Molecular B

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SummarySelenium (Se) is an essential trace element in mammals. Dietary Se restriction or conditions of Se malabsorption lead to deficiency syndromes or exacerbate established diseases in humans and in many animal models. It is assumed that most, if not all, physiological actions of Se are mediated by selenocysteine (Sec) containing proteins. However, the exact role of particular selenoproteins for certain molecular pathways, for the metabolism of nutrients, hormones or cellular components and for the development and adaptive responses of the organism have often remained elusive. Through the use of transgenic animals, it becomes increasingly feasible to interfere specifically with the expression of single selenoproteins in certain tissues or at certain times. While some transgenic animals exhibit phenotypes that were expected from biochemical studies, in other instances the observed effects were a surprise in view of earlier hypotheses. IUBMB Life, 57: 737 -744, 2005

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Hepatically derived selenoprotein P is a key factor for kidney but not for brain selenium supply

Cited by 190 publications

References 34 publications

Dietary lycopenes, selenium compounds and fish oil affect the profile of fatty acids and oxidative stress in chicken breast muscle

Dietary lycopenes, selenium compounds and fish oil affect the profile of fatty acids and oxidative stress in chicken breast muscle

Deletion of Apolipoprotein E Receptor-2 in Mice Lowers Brain Selenium and Causes Severe Neurological Dysfunction and Death When a Low-Selenium Diet Is Fed

New insights into the physiological actions of selenoproteins from genetically modified mice

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