Hepatitis a Vaccination in Chronic Liver Disease: Is It Really Required in a Tropical Country Like India?

Joshi, Nayana; Rao, S; Kumar, Ajit; Patil, Satish G; Rani, S

doi:10.1016/s0255-0857(21)02172-1

Indian Journal of Medical Microbiology

2007

DOI: 10.1016/s0255-0857(21)02172-1

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Hepatitis a Vaccination in Chronic Liver Disease: Is It Really Required in a Tropical Country Like India?

Nayana Joshi

S Rao

Ajit Kumar

et al.

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“…Patients with cirrhosis have significant immune dysfunction. They are at increased risk of bacterial and viral infections, including hepatitis A virus (HAV) [1,2]. Acute HAV infection in these patients may result in acute-on-chronic liver failure, which is associated with poor outcomes.…”

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“…Acute HAV infection in these patients may result in acute-on-chronic liver failure, which is associated with poor outcomes. Indian studies in the past, done more than 10 years back, noted that 93.2-99% of patients with chronic liver disease or cirrhosis have evidence of past infection with HAV [1][2][3][4]. However, with improving standards of hygiene and sanitation, it is likely that seroprevalence of HAV antibodies is on the decline.…”

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Seroprevalence of hepatitis A antibodies in patients with cirrhosis of liver

Jain¹

2022

ceh

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confidence: 99%

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confidence: 99%

Seroprevalence of hepatitis A antibodies in patients with cirrhosis of liver

Jain¹

2022

ceh

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Co-Occurrence of Hepatitis A Infection and Chronic Liver Disease

Sasaki

Masuzaki

Takahashi

et al. 2020

IJMS

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Hepatitis A virus (HAV) infection occasionally leads to a critical condition in patients with or without chronic liver diseases. Acute-on-chronic liver disease includes acute-on-chronic liver failure (ACLF) and non-ACLF. In this review, we searched the literature concerning the association between HAV infection and chronic liver diseases in PubMed. Chronic liver diseases, such as metabolic associated fatty liver disease and alcoholic liver disease, coinfection with other viruses, and host genetic factors may be associated with severe hepatitis A. It is important to understand these conditions and mechanisms. There may be no etiological correlation between liver failure and HAV infection, but there is an association between the level of chronic liver damage and the severity of acute-on-chronic liver disease. While the application of an HAV vaccination is important for preventing HAV infection, the development of antivirals against HAV may be important for preventing the development of ACLF with HAV infection as an acute insult. The latter is all the more urgent given that the lives of patients with HAV infection and a chronic liver disease of another etiology may be at immediate risk.

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Hepatitis B, Hepatitis A, and Pneumococcal Immunization Status in Patients with Cirrhosis of the Liver

Jain¹,

Sanglodkar

Venkataraman

2023

Gastroenterology, Hepatology and Endoscopy Practice

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Background and Aims: Immunization against hepatitis A, hepatitis B, and pneumococcus has been recommended in patients with cirrhosis of the liver. This questionnaire survey was undertaken to determine the rates of vaccination against these organisms in a cohort of patients with liver disease in India. Methods: We included all patients who were willing for the study and had been seen by a gastroenterologist/hepatologist at least once. Patients offering incomplete information were excluded from the study. Serological tests for confirmation of immunological response were not done. Details of counseling and vaccination status for hepatitis B, hepatitis A, and pneumococcal infection were noted. Results: A total of 305 patients (272 males, 89%) formed the study cohort. The median age was 60 years (range 27–76 years) and the median duration of liver disease was 12 months (1–120 months). The median model of end stage liver disease (MELD) was 14 (range 7–35). Only 37 (12.1%) patients reported that they had been counseled for vaccination against these infections. The rates of vaccination were very low (<10%). Conclusion: Very dismal vaccination rates were noted in Indian patients with liver cirrhosis.

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Hepatitis a Vaccination in Chronic Liver Disease: Is It Really Required in a Tropical Country Like India?

Cited by 3 publications

References 4 publications

Seroprevalence of hepatitis A antibodies in patients with cirrhosis of liver

Seroprevalence of hepatitis A antibodies in patients with cirrhosis of liver

Co-Occurrence of Hepatitis A Infection and Chronic Liver Disease

Hepatitis B, Hepatitis A, and Pneumococcal Immunization Status in Patients with Cirrhosis of the Liver

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