Hepatitis B and C in Children

Sperry, A. Bailey; Bennett, A. F.; Wen, Jessica

doi:10.1016/j.cld.2022.03.005

Cited by 8 publications

(6 citation statements)

References 99 publications

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“…1 H, 13 C NMR spectra, 2D HMBC and 2D HSQC were recorded on Bruker-400 NMR spectrometers. 1 H spectra were recorded relative to CDCl3 (7.26 ppm) or TMS (0.00 ppm) as internal standard, and 13 C NMR spectra were recorded relative to CDCl3 (77.0 ppm). High resolution mass spectra were performed on BioTOF Q instrument by electrospray ionization (ESI).…”

Section: Methodsmentioning

confidence: 99%

“…Hepatitis B is one of the most prevalent viral diseases in the world and about three hundred million individuals worldwide are chronically infected with HBV. [1] Thus, there is a continuing need for new therapies for individuals infected with HBV. Entecavir (Figure 1), a nucleoside analogue that inhibits the viral polymerase at priming, reverse transcription, and DNAdependent DNA synthesis steps [2] involved in the synthesis of viral DNA of HBV, was discovered by chemists from Bristol-Myers Squibb and approved by the Federal Drug Administration of USA in 2005.…”

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confidence: 99%

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Stereoselective Total Synthesis of Stereoisomers of Entecavir

Wang

Pei²,

et al. 2023

Synthesis

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Practical methods for the synthesis of three stereoisomers of Entecavir have been developed. Starting from the reported intermediate (1S,2R)-2-((benzyloxy)methyl)cyclopent-3-en-1-ol (3) and (1R,2S)-2-((benzyloxy)methyl)cyclopent-3-en-1-ol (4), respectively, three stereoisomers of Entecavir have been prepared with 17-20% overall yields. In principle, other stereoisomers could also be prepared by the materials and reactions used in this article.

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Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

Stereoselective Total Synthesis of Stereoisomers of Entecavir

Wang

Pei²,

et al. 2023

Synthesis

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“…The results of this study will provide important information for public health professionals and policymakers on the effectiveness of community health education in preventing the spread of hepatitis B and C. The study results can also inform the development of future educational interventions aimed at preventing the spread of these diseases. (Sperry, et al 2022) The study will include a pre-and post-education survey of individuals in a speci c community. The survey will assess participants' knowledge of hepatitis B and C transmission and prevention, as well as their attitudes and practices related to these issues.…”

Section: )mentioning

confidence: 99%

Assessing the Impact of Community Health Education on Hepatitis B and C Prevention

Areqi,

Muslot,

Muslot

2023

Preprint

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This study assesses the impact of community health education on hepatitis B and C prevention, focusing on knowledge levels and behavior change among participants. A quasi-experimental design, specifically a pre- and post-test design, was employed to evaluate the effectiveness of the intervention. The study was conducted in a selected community with a high proportion of individuals at risk of hepatitis B and C. Participants were recruited through community organizations and local health clinics. Data was collected through pre- and post-intervention assessments, measuring participants' knowledge and behaviors related to hepatitis B and C prevention. The community health education intervention consisted of educational sessions, distribution of informational materials, and interactive activities. Paired sample t-tests were conducted to analyze the changes in knowledge and behavior scores before and after the intervention. The results showed a significant improvement in participants' knowledge levels regarding hepatitis B and C after the intervention. Participants demonstrated increased understanding of transmission routes, symptoms and signs, prevention methods, treatment options, and the importance of vaccination. The intervention had a positive impact on behavior change, with participants showing an increase in the utilization of barrier methods and safe injection practices, as well as a reduction in needle-sharing behavior. These findings indicate that community health education is effective in enhancing knowledge and promoting positive behaviors related to hepatitis B and C prevention. The study supports the value of educational interventions in empowering individuals to make informed decisions and adopt preventive practices. By equipping individuals with accurate information and promoting behavior change, community health education programs contribute to reducing the incidence and prevalence of hepatitis B and C infections..

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“…As transmissões pelas vias vertical e sexual também ocorrem (18,19). Aproximadamente 4% a 7% das mães infectadas pelo VHC transmitem o vírus para seus recémnascidos (18).…”

Section: Modos De Transmissão E Fatores De Riscounclassified

“…As transmissões pelas vias vertical e sexual também ocorrem (18,19). Aproximadamente 4% a 7% das mães infectadas pelo VHC transmitem o vírus para seus recémnascidos (18). Quanto à transmissão do vírus através de relações sexuais, ocorre quando estas são realizadas sem proteção (19).…”

Section: Modos De Transmissão E Fatores De Riscounclassified

Mortalidade por hepatite C crônica no Brasil no período de 2000 a 2019: análise das causas múltiplas de morte

Festa

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minha estimada orientadora, expresso profundos agradecimentos pela generosa oportunidade concedida, pela notável paciência em suas orientações, constante disponibilidade e pela amizade que compartilhamos.Ao Dr. Heitor Franco de Andrade Júnior, expresso minha sincera gratidão por, nos momentos de cansaço e incerteza, sempre me incentivar com suas palavras de afeto e sabedoria.Ao Alec Brian Lacerda, estimado colega de profissão, dirijo meus agradecimentos pela generosidade em compartilhar seus ensinamentos e pela parceria valiosa durante esta importante etapa da minha trajetória acadêmica.Ao meu namorado, Luiz Gustavo, dedico meus agradecimentos pela paciência e compreensão demonstradas ao longo de todo o período de realização deste estudo. Suas palavras de incentivo e apoio nos momentos de dificuldade foram verdadeiros alentos.Às queridas amigas Lilith e Tenili, expresso minha gratidão por acreditarem em mim e por sempre me cercarem com alegria e esperança.A todos os meus amigos, manifesto minha gratidão pelo apoio e pelos momentos felizes compartilhados ao longo destes anos. Vocês foram essenciais neste processo."Não esqueça que a realidade é mutante, não esqueça que o novo pode surgir e, de todo modo, vai surgir".

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Hepatitis B and C in Children

Cited by 8 publications

References 99 publications

Stereoselective Total Synthesis of Stereoisomers of Entecavir

Stereoselective Total Synthesis of Stereoisomers of Entecavir

Assessing the Impact of Community Health Education on Hepatitis B and C Prevention

Mortalidade por hepatite C crônica no Brasil no período de 2000 a 2019: análise das causas múltiplas de morte

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