2014
DOI: 10.1053/j.gastro.2013.12.024
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Hepatitis B and D Viruses Exploit Sodium Taurocholate Co-transporting Polypeptide for Species-Specific Entry into Hepatocytes

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Cited by 678 publications
(868 citation statements)
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References 34 publications
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“…Comparative infection experiments were performed between Huh7 hNTCP and HepG2 hNTCP cells. When both cell lines were inoculated with 1×10 4 MOI of HBV stock, Huh7 hNTCP cells exhibited weak susceptibility to HBV infection compared to HepG2 hNTCP cells under 2.5% DMSO treatment, with a small proportion of cells infected (Ni et al, 2014). However, in the present study, approximately 50% of Huh7D hNTCP cells were infected at a MOI of 2000, and they were more susceptible than HepG2 hNTCP cells.…”
Section: Discussioncontrasting
confidence: 59%
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“…Comparative infection experiments were performed between Huh7 hNTCP and HepG2 hNTCP cells. When both cell lines were inoculated with 1×10 4 MOI of HBV stock, Huh7 hNTCP cells exhibited weak susceptibility to HBV infection compared to HepG2 hNTCP cells under 2.5% DMSO treatment, with a small proportion of cells infected (Ni et al, 2014). However, in the present study, approximately 50% of Huh7D hNTCP cells were infected at a MOI of 2000, and they were more susceptible than HepG2 hNTCP cells.…”
Section: Discussioncontrasting
confidence: 59%
“…Normally, 4% PEG8000 is added to the incubation medium during infection to enhance HBV attachment (Gripon et al, 1993); thus, resistance to 4% PEG8000 was another prerequisite for the cell line to ensure productive HBV infection. Therefore, this aspect of Huh7D cells was tested and further confirmed by comparison with HepG2 cells, the platform for an existing HBV infection cell model (HepG2 hNTCP ) (Yan et al, 2012;Ni et al, 2014). As shown in Figure 1B, there were no significant differences between the presence and absence of PEG8000 for all time points except the first day, indicating that Huh7D cells were tolerant to 4% PEG8000.…”
Section: Resistance To Dmso and Peg8000mentioning
confidence: 79%
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“…We also used Hex 8.0.0 in docking of HBF-0259 together with any of Alisporivir, NIM811, SCY635 and Sanglifehrin A compounds in correlation with secretory molecules. Since ASGPR/FNIII1 and SCCA1/ Pre-S1 [8,31] ASGPRCRD [41] and SCCA1 [8] 1DV8 [17] and 2ZV6 [43] Pre-S2 [3,8] FTL [8] and FNIII 1 [41] 2FG4 [35] and 2HA1 [34] Pre-S1 [20 [7,9].…”
Section: Docking Software and Parametersmentioning
confidence: 99%
“…These includes Myrcludex-B [43], Cyclosporin A (CsA), progesterone, propranolol and bosentan [73]. NTCP substrates, such as taurocholate, tauroursodeoxycholate and bromosulfophthalein, also inhibited HBV infection [43,49,73].…”
Section: Sodium Taurocholate Cotransporting Polypeptide (Ntcp)mentioning
confidence: 99%