Hepatitis B and Delta: clinical aspects of patients in the Brazilian Western Amazonia

Introduction. Hepatitis delta virus (HDV) is a small, defective RNA virus that is related more to plant viroids than to other human pathogens. Material and methods. Nearly 50 research articles from various sources were reviewed and a comprehensive analysis was done regarding various parameters concerning HDV. Articles published over a period of 30 years were selected based on their experimental and statistical relevance to HDV. This review gives a brief insight into epidemiology, genetics, clinical evolution and treatment of chronic hepatitis delta. Results. Chronic hepatitis delta remains a major cause of morbidity in Eastern European countries and the Mediterranean region. At the same time, there is a resurgence of HBV and HDV infection in young people (under the age of 50) in Western Europe, as a consequence of the intra-familial and sexual mode of acquisition among immigrants from Eastern Europe, the Mediterranean region and from countries of the former Soviet Union, Africa high burdened regions of Asia and South America. Prevalence among IVDU was found to be higher especially in western european countries and other regions of low HDV prevalence. Chronic delta viral hepatitis is a dynamic, progressive process. A direct cytopathic pattern of liver tissue damage was also observed, especially in the presence of HDV genotype 3. Chronic hepatitis D is reported to progress to cirrhosis and hepatocellular cancer, and this trend is greater the higher the level of HDV viremia at the time of presentation. Conclusions. Flaws in screening and on-time diagnosis still remain due to the insufficient research and data available. While still not classified as a carcinogen by IARC, our review ends up in support of the notion that HDV infection increases the chances and fastens the pathogenic processes leading to HCC.

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“…Larger tumours were found in HDV-positive patients. Higher CLIP score and universal presence of cirrhosis was also found (41).…”

Section: Moldovamentioning

confidence: 83%

Chronic delta hepatitis: from discovery to new treatments

Turcanu

Wani

2021

OH&RM

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“…A infecção causada pelo vírus B possui um período de incubação que varia de 30 a 180 dias, tendo como principais vias de transmissão: perinatal, parceiros sexuais e por via parenteral (EVANGELISTA CBA, et al,2021). Pode apresentar uma variedade de apresentações clínicas, desde portador assintomático a manifestações graves como hepatite crônica, hepatite fulminante, cirrose e Carcinoma Hepatocelular (CHC) (OLIVEIRA MS, et al, 2019).…”

Section: Introductionunclassified

Perfil epidemiológico das hepatites B e C em Maceió-AL no período de 2010-2020

et al. 2021

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Objetivo: Caracterizar o perfil epidemiológico dos pacientes infectados pelo vírus da hepatite B e C no período de 2010-2020 na cidade de Maceió - AL. Métodos: Trata-se de um estudo observacional, descritivo, do tipo transversal, realizado a partir de dados não nominais, extraídos do Sistema de Informação de Agravos de Notificação (SINAN), disponibilizados em planilhas de Excel pela secretaria de saúde municipal. A análise dos dados foi feita por meio de estatística descritiva das variáveis estudadas: sexo, faixa etária, raça/cor, nível de escolaridade e apresentação clínica. As diferenças foram consideradas significativas para os valores de p menores que 0,05. Resultados: O número de infectados por hepatites virais no município de Maceió de 2010 a 2020 foi de 2.570 casos. As infecções mais prevalentes foram decorrentes de HBV e HCV, sem qualquer notificação de HDV e HEV. Conclusão: Na capital alagoana as hepatites mais predominantes são B e C, onde a B foi a mais prevalente de 2010 a 2020. Sendo o sexo masculino, indivíduos na faixa etária dos 40 aos 59 anos, de raça parda, com ensino fundamental incompleto e em fase crônica da doença os mais acometidos.

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Hepatitis B and Delta: clinical aspects of patients in the Brazilian Western Amazonia

Cited by 2 publications

References 24 publications

Chronic delta hepatitis: from discovery to new treatments

Chronic delta hepatitis: from discovery to new treatments

Perfil epidemiológico das hepatites B e C em Maceió-AL no período de 2010-2020

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