Hepatitis B Associated Monoclonal Gammopathy That Resolved after Successful Liver Transplant

Abstract

Monoclonal gammopathy of undetermined significance (MGUS) has been most commonly associated with diseases like multiple myeloma, Waldenstrom's macroglobulinemia, primary systemic amyloidosis, HIV, and other lymphoproliferative disorders. There has been an isolated report of MGUS in patients coinfected with HIV and Hepatitis B, as the work by Amara et al. in 2006. Here, we report a case of IgA-kappa light chain gammopathy secondary to Hepatitis B infection, which resolved after liver transplantation. To our knowledge, this is the first reported case of M protein spike seen in the context of Hepatitis B infection only.

Detectable serum IgM monoclonal gammopathy in non-hepatitis-associated mixed cryoglobulinemic glomerulonephritis: A case report and literature review

“… 25 Recently, a retrospective study showed that patients with non-hepatitis-associated cryoglobulinemic glomerulonephritis were associated with hematologic conditions and responded well to clone-directed therapy. 5 There has been no evidence whether the use of clone-directed therapy in patients with monoclonal gammopathy-related mixed cryoglobulinemia but without hematologic malignancy (such as patients with chronic HBV or HCV infection) 26 – 28 could result in better disease control and prevent malignancy transformation.…”