Hepatitis B, C, and D Virus Infections and AFP Tumor Marker Prevalence Among the Elderly Population in Mongolia: A Nationwide Survey

Dambadarjaa, Davaalkham; Mukhtar, Yerkyebulan; Enkh-Oyun, Tsogzolbaatar; Khuyag, Ser-Od; Dayan, Angarmurun; Oyunbileg, Nandin-Erdene; Shagdarsuren, Oyu-Erdene; Nyam, Gunchmaa; Nakamura, Yosikazu; Takahashi, Masaharu; Okamoto, Hiroaki

doi:10.3961/jpmph.21.573

Cited by 3 publications

(1 citation statement)

References 28 publications

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“…AFP is presently the prevailing biomarker employed for the early detection of liver cancer 24 . The expression of AFP is elevated in certain individuals diagnosed with hepatitis, germ cell tumors, and gastric cancer [25][26][27] . Hence, it is of utmost signi cance to ascertain biomarkers that can monitor LIHC.…”

Section: Discussionmentioning

confidence: 99%

Expressional and prognostic value of CRLF3 in liver hepatocellular carcinoma patients via integrated bioinformatics analyses and experiments

王,

Huang,

Huang

et al. 2024

Preprint

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BACKGROUND: Liver hepatocellular carcinoma (LIHC) exhibits a notable prevalence and fatality rate, posing a significant risk to human well-being. 1. The orphan cytokine receptor-like factor 3 (CRLF3), which exhibits evolutionary conservation, has been associated with hematopoiesis in vertebrates, human diseases, and neuroprotection in insects 2,3. However, there is a dearth of research investigating the role of CRLF3 in LIHC and the underlying mechanisms involved. METHODS: The researchers utilized the TCGA database to examine the putative regulatory association between the expression of CRLF3 mRNA and LIHC.The Human Protein Atlas (HPA) has made available visual representations of the expression patterns of the CRLF3 protein. To determine the protein expression levels of CRLF3 in LIHC and adjacent normal tissues, immunohistochemistry techniques were employed.The study employed the Kaplan-Meier method, Cox regression, and logistic regression to evaluate the association between CRLF3 mRNA expression levels and survival outcomes and prognosis. In this study, the researchers employed GO and Kyoto KEGG pathway enrichment analyses, as well as GSEA, to investigate the potential regulatory role of CRLF3. The biological function of CRLF3 was identified using the ssGSEA technique. RESULTS: The primary objective of this study is to assess the levels of expression exhibited by various members of the CRLF family in LIHC and analyze their potential influence on prognosis. The mRNA expression levels of CRLF3 exhibited a significant increase in LIHC tissues, both at the transcript and protein levels. Furthermore, research has demonstrated that patients exhibiting elevated levels of CRLF3 in LIHC experience diminished OS, DSS, and PFI. Several clinicopathologic parameters, including clinical T stage, pathologic stage, histologic grade, and AFP concentration, have been seen to exhibit associations with CRLF3 expression in LIHC. The study used multivariate survival analysis to establish that CRLF3 served as an independent predictive factor. Additional enrichment analysis was conducted, which demonstrated that the PI3K Akt, Wnt, FcεRI-mediated NF-κB activation, activation of the intestinal immune network for the IgA production, interactions between immune cells and microRNAs in the tumor microenvironment, and JAK/STAT signaling pathways exhibited significant enrichment in the group with high CRLF3 expression. The ssGSEA analysis revealed a significant positive connection between the expression of CRLF3 and the presence of T helper 2 (Th2) and T helper cells. CONCLUSIONS: Increased CRLF3 in LIHC is strongly linked to decreased survival and immune infiltration invasion. Based on the findings of our study, it is suggested that CRLF3 has the potential as a prognostic marker for unfavorable outcomes and might serve as a viable target for immunotherapeutic interventions in the management of LIHC.

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Section: Discussionmentioning

confidence: 99%

Expressional and prognostic value of CRLF3 in liver hepatocellular carcinoma patients via integrated bioinformatics analyses and experiments

王,

Huang,

Huang

et al. 2024

Preprint

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The values of systemic immune-inflammation index and neutrophil-lymphocyte ratio in predicting testicular germ cell tumors: A retrospective clinical study

Wang

Yang

et al. 2022

Front. Oncol.

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Genetic Diversity and Possible Origins of the Hepatitis B Virus in Siberian Natives

Manuylov

Chulanov

Bezuglova

et al. 2022

Viruses

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A total of 381 hepatitis B virus (HBV) DNA sequences collected from nine groups of Siberian native populations were phylogenetically analyzed along with 179 HBV strains sampled in different urban populations of former western USSR republics and 50 strains from Central Asian republics and Mongolia. Different HBV subgenotypes predominated in various native Siberian populations. Subgenotype D1 was dominant in Altaian Kazakhs (100%), Tuvans (100%), and Teleuts (100%) of southern Siberia as well as in Dolgans and Nganasans (69%), who inhabit the polar Taimyr Peninsula. D2 was the most prevalent subgenotype in the combined group of Nenets, Komi, and Khants of the northern Yamalo-Nenets Autonomous Region (71%) and in Yakuts (36%) from northeastern Siberia. D3 was the main subgenotype in South Altaians (76%) and Buryats (40%) of southeastern Siberia, and in Chukchi (51%) of the Russian Far East. Subgenotype C2 was found in Taimyr (19%) and Chukchi (27%), while subgenotype A2 was common in Yakuts (33%). In contrast, D2 was dominant (56%) in urban populations of the former western USSR, and D1 (62%) in Central Asian republics and Mongolia. Statistical analysis demonstrated that the studied groups are epidemiologically isolated from each other and might have contracted HBV from different sources during the settlement of Siberia.

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Hepatitis B, C, and D Virus Infections and AFP Tumor Marker Prevalence Among the Elderly Population in Mongolia: A Nationwide Survey

Cited by 3 publications

References 28 publications

Expressional and prognostic value of CRLF3 in liver hepatocellular carcinoma patients via integrated bioinformatics analyses and experiments

Expressional and prognostic value of CRLF3 in liver hepatocellular carcinoma patients via integrated bioinformatics analyses and experiments

The values of systemic immune-inflammation index and neutrophil-lymphocyte ratio in predicting testicular germ cell tumors: A retrospective clinical study

Genetic Diversity and Possible Origins of the Hepatitis B Virus in Siberian Natives

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