Hepatitis B Seroprotection and the Response to a Challenging Dose among Vaccinated Children in Red Sea Governorate

Sami, Samia M.; Salama, Iman I.; Abdel‐Latif, Ghada A.; Etreby, Lobna A. El; Metwally, Ahmed Ibraheam El; Haliem, Naglaa F. Abd El

doi:10.3889/oamjms.2016.043

Cited by 9 publications

(10 citation statements)

References 27 publications

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“…In our study protective level of HBsAb decreased with age from 65% in children below 5 years to 15.3% in those above 10 years. Similar findings were reported in Egypt and China where the protection rate was inversely correlated with age [24, 25]. A study conducted in Yemen assessed the hepatitis B vaccine coverage and immune response in children below ten years and reported a 45.2% children with low levels of HBs (< 10 UI/L) despite a full course of 3 doses vaccine [26].…”

Section: Discussionsupporting

confidence: 66%

Hepatitis B virus (HBV) infection amongst children in Senegal: current prevalence and seroprotection level

Lô¹,

Sow-Sall²,

Diop-Ndiaye³

et al. 2019

Pan Afr Med J

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Introduction Hepatitis B virus (HBV) infection is highly endemic in Senegal. HBV vaccine of all children has been introduced in 1999 and included in the Expanded Programme on Immunization in 2004. The aim of this study was to assess the HBV prevalence and immunity status against HBV amongst children in Senegal. Methods Between March and August 2016, consecutive children aged from 6 months to 16 years old were recruited in outpatient department of three main children hospitals in Senegal. Serum samples were analyzed for HBV serology (HBsAg, HBcAb, HBsAb) using ARCHITECT analyzer. Children with HBsAb levels ≥ 10 IU/l) were considered as seroprotected against HBV. Results During the study period, 295 children fulfilled the criteria for the study and were further analyzed. Three children were HBsAg positive giving a seroprevalence at 1.1% (95% CI: 0.2-3.3), 12/267 (4.5%, 95% CI=2.3-7.7) had positive HBcAb and 226/295 (76.6%, 71.4-81.3) had positive HBsAb including 191 (77.3%, 71.6-82.4) with isolated HBsAb related to previous active immunization. However only 165 children (56%, CI 50-62) had seroprotective HBsAb levels (HBsAb ≥ 10 UI/L) and 63 (21.4, 16.8-26) had a strong seroprotectiondefined by HBsAb ≥ 100 IU/L. Conclusion Our results suggest that although HBV prevalence has significantly decreased in children in Senegal following a better HBV vaccine coverage, the number of children correctly seroprotected is insufficient (56%). Assessing the levels of HBsAb and providing HBV vaccine boosters should be considered in children in Senegal.

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Section: Discussionsupporting

confidence: 66%

Hepatitis B virus (HBV) infection amongst children in Senegal: current prevalence and seroprotection level

Lô¹,

Sow-Sall²,

Diop-Ndiaye³

et al. 2019

Pan Afr Med J

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“…This variation in seroprotection rates may be due to uneven sample sizes in each category. This decrease in rate and level of seroprotection in group C compared to groups A and B in the current study may be logically a result to advance in years of age in group C as age is recognized as a well-established risk factor for gradual depletion of anti-HBs concentrations [18,22,23], or it may be a result to birth dose administration in groups A and B which is supposed to be the root cause for elevation in the rates and levels of seroprotection in these two groups (A and B).…”

Section: Discussionmentioning

confidence: 55%

“…The present study revealed that the total sero-protection rate among ages ranging from 9 months till 10 years in fully vaccinated children with recombinant HBV vaccine during infancy was 86% (154 children out of 179 participants), 48.3% of them were low level seroprotected while 51.9% of them were high level seroprotected. However [16][17][18]. Also, lower percentages were reported in the same age range by Al-Shamahy et al, 2011 [19], their study revealed that only 54.8% of vaccinated healthy children from 1 to 10 years were seroprotected.…”

Section: Discussionmentioning

confidence: 89%

Assessment of hepatitis B virus immune status among hepatitis B virus vaccinated children.

Bakr

Sherbini

Aboulela

et al. 2022

Microbes and Infectious Diseases

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Background:: Vaccination compared to other measures is considered the most efficient and cost-effective strategy against hepatitis B virus (HBV) infection which decreases the incidence of both HBV infection and hepatocellular carcinoma. This study involved 179 children vaccinated against HBV during infancy, and aimed to assess the immune status against HBV among HBV vaccinated children in different age groups. Methods: Participants were chosen according to previously settled inclusion and exclusion criteria. Recruited participants' ages ranged from 9 months till 10 years who had received the full routine infancy vaccination course. Participants were divided according to age into three groups: group A ages from 9 months to less than 2 years of age (41 children 22.9%), group B ages from 2 years to less than 5 years (64 children 35.8%), and group C ages from 6 years to 10 years (74 children 41.3%). Serum levels of antiHBs were measured. Results: Out of 179 participants, there were 154 children (86%) seroprotected, while 25 children (14%) were not. Moreover, 100% of children under 3 years were seroprotected. Seroprotection rate under 5 years was 95.2%. While in group C seroprotection rate was 73%. Males showed a slightly higher seroprotection rate than females although statically insignificant. Conclusion: Universal hepatitis B vaccination shows excellent effectiveness in Egypt. Total seroprotection rate (86%) is higher than in previous local and global studies that may return to the recent implementation of birth dose in Egypt.

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“…The sample frame for the survey was based on the population census of Egypt, 2006. Details of sample size and sampling design of the project are reported in previous work [14].…”

Section: Methodsmentioning

confidence: 99%

A Nationwide Community Survey of Prevalence of Circumcision among Egyptian Children and Risk of Hepatitis B Viral Infection

Salama

Sami

Salama

et al. 2021

Open Access Maced J Med Sci

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AIM: To assess prevalence and risk factors of circumcision among Egyptian children and to assess the risk factors for HBV infection among them. METHODS: A nationwide community survey was carried out on 3306 children aged from 9 months to 16 years, of both genders. Data were collected during face to face interviews with the parents and children. All studied children had received HBV vaccination during infancy. Total anti-HBc and HBsAg were assessed by ELISA followed by HBV DNA detection for positive cases by Real-time PCR. RESULTS: Prevalence of circumcision was 92.3% among boys and 29.7% among girls. The percentage of circumcised girls was significantly higher in rural (38.1%) than urban (21.1%), P<0.01 and more in Upper (42.2%) and Lower Egypt (27.6%) compared to Cairo, the Capital (14.1%), P˂0.001. Boys showed significantly higher prevalence of circumcision in urban (94.1%) compared to rural areas (90.1%), P˂ 0.001.The prevalence of HBV breakthrough infection, detected by HBV-DNA, was 14/3306 (0.42%). No significant differences between circumcised and non-circumcised boys and girls regarding the different serological tests of HBV infection, P > 0.05. Using logistic regression analysis, mothers’ illiteracy or having primary and preparatory education carried six times and 2 times risk respectively of having their daughter circumcised compared to higher education, P < 0.01. Living in Upper or Lower Egypt carried three times and 1.5 times risk respectively of having circumcised girl compared to the Capital, P < 0.001. HBV infection among family was the independent risk factor for HBV infection among girls and boys, in addition to frequent medical injection among boys, P < 0.05. CONCLUSION: Circumcision among girls is still a problem especially in Upper Egypt and in rural areas. Child circumcision in Egypt seems not to play a role in HBV infection and intra-familial HBV transmission and frequent medical injection are the most important risk factors.

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Hepatitis B Seroprotection and the Response to a Challenging Dose among Vaccinated Children in Red Sea Governorate

Cited by 9 publications

References 27 publications

Hepatitis B virus (HBV) infection amongst children in Senegal: current prevalence and seroprotection level

Hepatitis B virus (HBV) infection amongst children in Senegal: current prevalence and seroprotection level

Assessment of hepatitis B virus immune status among hepatitis B virus vaccinated children.

A Nationwide Community Survey of Prevalence of Circumcision among Egyptian Children and Risk of Hepatitis B Viral Infection

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