Hepatitis B virus genotypes/subgenotypes in voluntary blood donors in Makassar, South Sulawesi, Indonesia

Utama, Andi; Octavia, Theresia Imelda; Dhenni, Rama; Miskad, Upik Anderiani; Yusuf, Irawan; Tai, Susan

doi:10.1186/1743-422x-6-128

Cited by 24 publications

(22 citation statements)

References 39 publications

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“…The present study indicated that the distribution of three HBV genotypes (B, C, and D) and two predominant subgenotypes (C6 and D6) are nearly equal between the Austronesian language speakers and the Non‐Austronesian language speakers in the studied population, suggesting that the ancestors of Papuans was common to those of East Austronesian language speakers in the other regions in Indonesia. In support of this speculation, subgenotype D6 was found among the subjects in not only Papua, but also Makassar on Sulawesi Island [Utama et al, 2009; Utsumi et al, 2009; this study], whose ancestors are the East Austronesian language speakers. However, HBV strains of the two novel subgenotypes C11 and C12 were found only within the Non‐Austronesian language speakers in Namblong and Merauke.…”

Section: Discussionsupporting

confidence: 74%

Analysis of the full‐length genomes of novel hepatitis B virus subgenotypes C11 and C12 in Papua, Indonesia

Mulyanto

Depamede

Wahyono

et al. 2010

Journal of Medical Virology

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Two novel subgenotypes (C6 and D6) of hepatitis B virus (HBV) were identified recently in Papua, a multiethnic area of Indonesia. To characterize further the HBV strains in Papua, serum samples collected from 59 viremic subjects (44 males and 15 females; mean age: 30.0 ± 15.5 years) among indigenous inhabitants in Papua, were subjected to phylogenetic analysis of an 1.6-kb partial sequence. Forty-five samples (76%) had genotype C HBV (HBV/C) [C5 (n = 1), C6 (n = 40), and unclassifiable (n = 4)], while seven samples (12%) were HBV/D [D1 (n = 1) and D6 (n = 6)] and six samples (10%) were HBV/B [B2 (n = 1), B3 (n = 3), B7 (n = 1), and B8 (n = 1)]; the remaining sample possessed B3 and C6. An analysis of the full-length sequence of the four HBV/C isolates (NMB09122, NMB09124, NMB09075, and MRK89073) that were unclassifiable into any of the 10 known HBV/C subgenotypes (C1-C10) showed no significant evidence of recombination. Over the entire genome, the NMB09122 and NMB09124 isolates shared 99.8% identity and segregated into a cluster with a bootstrap value of 100%, differing from HBV/C1-HBV/C10 by 3.8-6.9% (mean, ≥4.0%), indicating that NMB09122 and NMB09124 can be classified into a novel subgenotype within genotype C (tentatively designated C11). The NMB09075 and MRK89073 isolates were 97.4% identical to each other and differed from known HBV/C isolates, including the C11 strains, by 4.0-7.2% (mean, ≥4.5%) over the entire genome, indicating that NMB09075 and MRK89703 can be classified into another novel HBV/C subgenotype (C12). The distribution of C11 and C12 seemed to be associated with particular language speakers in Papua.

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Section: Discussionsupporting

confidence: 74%

Analysis of the full‐length genomes of novel hepatitis B virus subgenotypes C11 and C12 in Papua, Indonesia

Mulyanto

Depamede

Wahyono

et al. 2010

Journal of Medical Virology

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“…It has been also reported from Morocco and Russia and Baltic region [57,58,74]. D6: It has been reported as a rare subgenotype from Indonesia, Kenya, Russia and Baltic region [22][23][24][25][26]54,55,74].…”

Section: Subgenotypes Of Genotype Dmentioning

confidence: 87%

“…However, genotype C and B are prevalent and D is rare (around 1%) in Eastern China and among genotype D, D1 and D2 are noted [10]. The subgenotype distribution of genotype D is also different among parts of India [24][25][26][27][28][29][30]. Similarly subgenotype studies may help tracking the movements of some population.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of HBV subgenotypes D

Özaras

Balkan

Yemişen

et al. 2015

Clinics and Research in Hepatology and Gastroenterology

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“…New subgenotypes, D5 to D7 were later described in India [28], Indonesia [29], and in the Mediterranean Basin [30], respectively.…”

Section: Introductionmentioning

confidence: 99%

Characterization of Hepatitis B virus (HBV) genotypes in patients from Rondônia, Brazil

Santos¹,

Alvarado-Mora

Botelho

et al. 2010

Virol J

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BackgroundHepatitis B virus (HBV) can be classified into nine genotypes (A-I) defined by sequence divergence of more than 8% based on the complete genome. This study aims to identify the genotypic distribution of HBV in 40 HBsAg-positive patients from Rondônia, Brazil. A fragment of 1306 bp partially comprising surface and polymerase overlapping genes was amplified by PCR. Amplified DNA was purified and sequenced. Amplified DNA was purified and sequenced on an ABI PRISM® 377 Automatic Sequencer (Applied Biosystems, Foster City, CA, USA). The obtained sequences were aligned with reference sequences obtained from the GenBank using Clustal X software and then edited with Se-Al software. Phylogenetic analyses were conducted by the Markov Chain Monte Carlo (MCMC) approach using BEAST v.1.5.3.ResultsThe subgenotypes distribution was A1 (37.1%), D3 (22.8%), F2a (20.0%), D4 (17.1%) and D2 (2.8%).ConclusionsThese results for the first HBV genotypic characterization in Rondônia state are consistent with other studies in Brazil, showing the presence of several HBV genotypes that reflects the mixed origin of the population, involving descendants from Native Americans, Europeans, and Africans.

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Hepatitis B virus genotypes/subgenotypes in voluntary blood donors in Makassar, South Sulawesi, Indonesia

Abstract: HBV/B and HBV/C are dominant in Makassar, similar to most areas in Indonesia. Mutations in BCP which might be associated with severity of liver disease are less common.

Cited by 24 publications

References 39 publications

Analysis of the full‐length genomes of novel hepatitis B virus subgenotypes C11 and C12 in Papua, Indonesia

Analysis of the full‐length genomes of novel hepatitis B virus subgenotypes C11 and C12 in Papua, Indonesia

Epidemiology of HBV subgenotypes D

Characterization of Hepatitis B virus (HBV) genotypes in patients from Rondônia, Brazil

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