Hepatitis B Virus, Hepatitis C Virus Markers and Serum Alanine Amino-Transferase (ALT) Levels, in a Young Adult Population of Sylhet District

Perveen, Irin; Saha, Madhu Sudan; Dhar, Kishore Kumar; Islam, Shriful

doi:10.3329/jbcps.v34i4.32487

Cited by 1 publication

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“…These findings are supported by findings of other studies. 19 The higher level of ALT in males in this study is a supporting guide to follow the American Association for the Study of Liver Diseases (AASLD) for considering 30U/L and 19U/L levels for males and females, respectively. 20 Therefore, it is important to use these cut-off values in our clinical practice for managing HBeAg negative patients in Duhok.…”

Section: Discussionmentioning

confidence: 80%

Characteristics of patients with HBeAg negative chronic hepatitis B virus infection in Duhok, Kurdistan region

Merza¹,

Yousif

Younus

et al. 2018

Int J Res Med Sci

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Background: The objective of this study was to characterize patients with HBeAg-negative chronic hepatitis B in Duhok province.Methods: We recruited all patients with HBeAg negative chronic hepatitis B virus infections who visited viral hepatitis clinic in Azadi Teaching Hospital between September 2015-December 2017. The main evaluation parameters were: serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels, serum albumin, total serum bilirubin (TSB), viral load. Few patients were subjected to Fibro-test, Fibroscan, or liver biopsy.Results: There were 251 patients. The mean age of the patients was 35.75±14.40 years. One hundred fifty-seven cases were male and 94 cases were female. The baseline mean of ALT, AST and viral load was 42.09±2.71U/L, 30.26±19.65U/L, and 1421197.08±14436692.04IU/ml, respectively. Compared with women, men have significantly higher values of ALT and AST, serum albumin, and TSB. There were 217 chronic inactive carrier (IC) patients and 34 chronic active hepatitis (AH) patients. ALT, AST, and viral load levels were significantly higher among AH patients.Conclusions: The majority of patients showed nil to mild liver injury. The higher level of ALT in males is a supporting guide to follow the American Association for the Study of Liver Diseases (AASLD) considering 30U/L and 19U/L levels for males and females, respectively. There was preponderance of males in AH, which indicates greater frequency of advanced fibrosis in such patients. There was a greater probability of AH in old aged people. Serum albumin and TSB were not good markers for differentiation between AH and IC state. Twenty-four patients had ALT above twice upper limit of normal level, but 34 patients showed AH based on liver biopsy, firboscan or fibrotest.

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Section: Discussionmentioning

confidence: 80%

Characteristics of patients with HBeAg negative chronic hepatitis B virus infection in Duhok, Kurdistan region

Merza¹,

Yousif

Younus

et al. 2018

Int J Res Med Sci

View full text Add to dashboard Cite

show abstract

Hepatitis B Virus, Hepatitis C Virus Markers and Serum Alanine Amino-Transferase (ALT) Levels, in a Young Adult Population of Sylhet District

Abstract: Objective: To find out the seroprevalence of the hepatitis B and C viruses in a young adult population along with estimation of aminotransferase levels. And so as to increase the awareness and augment preventive measures against these viral hepatitis related morbidity. Methods

Cited by 1 publication

References 18 publications

Characteristics of patients with HBeAg negative chronic hepatitis B virus infection in Duhok, Kurdistan region

Characteristics of patients with HBeAg negative chronic hepatitis B virus infection in Duhok, Kurdistan region

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