Hepatitis C Virus Genotype 7, a New Genotype Originating from Central Africa

Murphy, Donald G.; Sablon, Erwin; Chamberland, Jasmine; Fournier, Éric; Dandavino, R; Tremblay, Cécile

doi:10.1128/jcm.02831-14

Cited by 162 publications

(120 citation statements)

References 19 publications

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“…Esta enzima catalisa a síntese de cadeia negativa que, por sua vez, serve como modelo para a nova síntese de novas cadeias positiva. Estes são então empacotados e em seguida, saem da célula via exocitose 30 . O vírus da hepatite C não tem capacidade de se integrar no genoma do hospedeiro.…”

Section: Epidemiologiaunclassified

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Hepatite B e C: diagnóstico e tratamento

Viana

Veloso²,

Neto³

et al. 2017

Rev Pat Tocantins

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INTRODUÇÃO: As hepatites virais são consideradas as principais doenças hepáticas, podendo levar a quadros mais graves, como a cirrose e o carcinoma hepatocelular, tornando-se um importante problema de saúde pública. Tem distribuição global com áreas de altos índices de endemicidade, sobretudo em países asiáticos. Os principais agentes envolvidos são os vírus da hepatite A, B, C, D, E. O vírus da hepatite B e C se destacam nesse meio devido à grande capacidade de cronificação. As formas de transmissão são basicamente através do contato com fluidos corporais infectados, através de transfusões sanguíneas, uso de drogas injetáveis, transmissão vertical, etc. METODOLOGIA: Trata-se de um artigo de revisão no qual, a partir das palavras “hepatite B” e “hepatite C”, foi realizado busca por periódicos nos bancos de dados: PubMed, Scielo, Portal Periódicos CAPES e Google acadêmico. CONCLUSÃO: As hepatites B e C podem se apresentar apenas de forma aguda, ou podem se cronificar. O diagnóstico geralmente é realizado tardiamente, pois, na grande maioria dos casos apresenta-se oligossintomáticas ou até mesmo assintomática. O diagnóstico é feito através de exames sorológicos e quantificação viral através do PCR. O tratamento é basicamente sintomático, porem nos casos crônicos, é indicado uso de medicações, como interferons peguilhados e análogos de nucleosideos. Palavras-chave: Hepatites virais; Hepatite B; Hepatite C. INTRODUCTION: Viral hepatitis are considered as one of the major liver diseases, being able to lead more severe outcomes, such as cirrhosis and hepatocellular carcinoma becoming an important public health problem. It has global distribution with areas of high endemicity, especially in Asian countries. The main agents involved are hepatitis A virus, B, C, D, E. The hepatitis B and C viruses stand out in the middle of a chronicling ability. As the transmission forms are basically through contact with infected body fluids, through blood transfusions, injecting drug use, vertical transmission, etc. METHODOLOGY: This is a review article, from the words "hepatitis B" and "Hepatitis C", was carried out by search for journals in databases: PubMed, Scielo, Portal Periodicos CAPES and Google academic. CONCLUSION: The hepatitis B and C can either be only a form of acute, or can be chronic. Therefore, the diagnosis is often late, since in the vast majority of cases it is oligosymptomatic or even asymptomatic. The diagnosis is made through serological tests and viral quantification through PCR. The treatment is basically with symptomatic, such as pegged interferon’s and nucleoside analogs. Keywords: Viral hepatitis; Hepatitis B; Hepatitis C.

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Section: Epidemiologiaunclassified

“…O teste direto para o RNA é necessário para distinguir entre infecção em curso ou prévia em pessoas com anticorpos contra o HCV (anti-HCV) 30 . Os pacientes devem ser triados inicialmente através do anti-HCV.…”

Section: Hepatite Cunclassified

Hepatite B e C: diagnóstico e tratamento

Viana

Veloso²,

Neto³

et al. 2017

Rev Pat Tocantins

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“…Генотипы 5 и 6 обнаружены в Южной Африке и Гонконге, а также в Китае, Юго-Восточной Азии, Таиланде и Вьетнаме. Недавно в Демократической Республике Конго выявлен абсолютно новый генотип 7 [35]. Гено-типы подразделяются на множество субтипов, число которых в разных генотипах варьируется.…”

Section: Introductionunclassified

Molecular Epidemiology Features of Hepatitis C Virus Isolates From Different Regions of the Republic Sakha (Yakutia)

Semenov¹,

Ostankova

Gerasimova

et al. 2016

Russian Journal of Infection and Immunity

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According to WHO data about 3% of population are infected by hepatitic C virus (HCV) worldwide. Chronic hepatitis C is the leading cause of cirrhosis and hepatocellular carcinoma, thus it becoming one of the global public health problems. Clinical manifestations are varied and depend mainly of the virus biological properties and its interaction with the host immune system. Determination of virus genotype and subtype is important for a better understanding of the epidemiological and virological features of the disease. The prevalence genotypes hepatitis C virus is varies in different geographical regions of the world. The data about HCV genotypes distribution in some Russian Federation regions are very limited, especially about HCV genotypes prevalence in Siberia, Far East and some rural regions. One of such regions is Yakutia. In our study we identified genetic variants of HCV in chronic hepatitis C patients with moderate and high viral load from Yakutia by direct sequencing of HCV RNA NS5B region. Based on phylogenetic analysis we found the prevalent genotype 1 (88.3%), than genotype 2 (6.7%) and 3 (3.2%) among HCV patients with moderate and high viral load. Our results on the prevalence of subtype 1b are consistent with the data on the connection between this subtype with high levels of viremia, greater duration and severity of liver disease, as well as the development of chronic hepatits C in patients infected by HCV subtype 1b, compared with those infected with other subtypes of hepatitis virus C. The similarity of some Yakutian isolates with isolates from the United States, Brazil and Ireland was found. We discuss HCV subtype 2a isolates identified origin from isolates found in China. First in the territory of the Russian Federation HCV subtype 3g was identified, presumably imported from South Asia. Interconnected use of molecular, virological, demographic and epidemiological methods and information to monitor the infections will contribute to the understanding of the current HCV epidemiology in Russia.

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“…In contrast, genotypes 2 (Europe and Mediterranean region), 3 (Asia), 4 (Middle East and central Africa), 5 (South Africa), 6 (Asia) and 7 (Central Africa) have a penetration that is more geographically specific. 11,13 …”

Section: The Hcvmentioning

confidence: 99%

Hepatitis C Virus Infection in Chronic Kidney Disease

Ladino

Pedraza

Roth

2016

JASN

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Soon after the hepatitis C virus (HCV) was identified in 1989, it was recognized that the prevalence of infection in patients with ESRD far exceeded that in the general population. Infection with HCV predisposes to the hepatic complications of cirrhosis and hepatocellular carcinoma. However, important extrahepatic manifestations include immune complex glomerular disease, accelerated progression of CKD, increases in cardiovascular event risk, and lymphoproliferative disorders. Advances in understanding the molecular biology of HCV have ushered in a new era in the treatment of this infection. Second generation direct-acting antiviral agents have revolutionized therapy, with sustained virologic response rates (undetectable viral load 12 weeks after completing therapy) of .90% in most patients. Studies using direct-acting antivirals in patients with CKD and those on dialysis are showing excellent safety and efficacy as well. In this context, it is imperative that nephrologists become familiar with this literature, reviewed here, so that the important decisions, including which patients should be treated and the optimal timing to initiate therapy, are vetted in association with the compounding issues of CKD, ESRD, and kidney transplantation.

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Hepatitis C Virus Genotype 7, a New Genotype Originating from Central Africa

Cited by 162 publications

References 19 publications

Hepatite B e C: diagnóstico e tratamento

Hepatite B e C: diagnóstico e tratamento

Molecular Epidemiology Features of Hepatitis C Virus Isolates From Different Regions of the Republic Sakha (Yakutia)

Hepatitis C Virus Infection in Chronic Kidney Disease

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