“…Furthermore, cell entry of HCV has been shown to occur via endocytosis and membrane fusion to be dependent on acidic pH and cholesterol. 10,14,16,26 How do oxidized lipoproteins interfere with HCV entry and what is the significance of this event in vivo? First, it is important to point out that lipoproteins are completely dispensable in infection assays in vitro with HCVpp or HCVcc.…”