Hepatitis C virus (HCV) diagnosis <i>via</i> microfluidics

Narayanamurthy, Vigneswaran; Jeroish, Z. E.; Bhuvaneshwari, K.; Samsuri, Fahmi

doi:10.1039/d0ay02045a

Cited by 21 publications

(12 citation statements)

References 157 publications

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“…Advancements in microfluidic technology have enabled much success in the fields of biochemistry and material synthesis. It has become a key component in single cell analysis, [ 233 ] diagnostic point‐of‐care devices for HIV, [ 234 ] and hepatitis C virus [ 235 ] detection, where it enables rapid testing and analysis. Microfluidics has also been be able to synthesize various types nanoparticles including liposomes, [ 236 ] solid lipid nanoparticles, [ 237 ] and gold nanoparticles [ 238 ] in a precise and reproducible manner.…”

Section: Discussionmentioning

confidence: 99%

A Review of Cyclic Olefin Copolymer Applications in Microfluidics and Microdevices

Agha

Waheed

Alamoodi

et al. 2022

Macro Materials & Eng

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Cyclic olefin copolymers (COC) are amorphous, transparent thermoplastics composed of cyclic olefin monomers (norbornene) and linear olefins (ethene). They are increasingly utilized as fabrication materials for microsystems and microfluidic devices, owing to their promising features of low water absorption, high electrical insulation, long-term stability of surface treatments, and resistance to a broad variety of acids and solvents. Many manufacturing processes for COC-based devices have been developed in recent decades. These methodologies are categorized as replication methods or fast prototyping as common in fabrication of thermoplastic microfluidic devices. This review gives a full discussion of the features of COCs, the various production processes, and the numerous selected applications in microfluidic platforms. The review also explores COC's composition and fundamental features, as well as fabrication processes and applications in a variety of fields, investigates the material's potential advantages and uses, and attempts to create a comprehensive list of COC's possible benefits. Due to their unique features and simplicity of fabrication, COCs are projected to advance the future of microfluidics, microsystems, and optofluidics.

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Section: Discussionmentioning

confidence: 99%

A Review of Cyclic Olefin Copolymer Applications in Microfluidics and Microdevices

Agha

Waheed

Alamoodi

et al. 2022

Macro Materials & Eng

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“…436 Discussions including commercial POC systems for STI testing, in particular for the four major curable STIs and HIV, have been provided by Adamson et 445 other reviews addressed more specifically HCV diagnosis via microfluidics or biosensors for hepatitis diagnostics (HBV and others). 446,447 Nath et al discussed laboratory and POC techniques for diagnosis of HSV infections. 448 Even if a wide range of STI diagnostic tools is currently available, high actual incidence rates of STI, emergence of antimicrobial drug resistance and the requirement of extended screening campaigns in low and middle-income countries motivate the development of new truly POC diagnostic devices with high sensitivity and short time-toresult.…”

Section: Current Sti Diagnostics Landscape and Recent Reviewsmentioning

confidence: 99%

Microfluidic systems for infectious disease diagnostics

Lehnert,

Gijs

2024

Lab Chip

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“…Miniaturised devices are extensively fabricated and possess good market potential; research are done to improvise the existing design strategies regarding relativity, sensitivity, detection time, and point-of-care diagnosis. Aptamers are essential in ligand–protein binding affinity with respect to their POC application (Narayanamurthy et al 2021 ).…”

Section: Design Strategies For Aptasensorsmentioning

confidence: 99%

Aptamer-based rapid diagnosis for point-of-care application

Futane

Narayanamurthy

Jadhav

et al. 2023

Microfluid Nanofluid

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Aptasensors have attracted considerable interest and widespread application in point-of-care testing worldwide. One of the biggest challenges of a point-of-care (POC) is the reduction of treatment time compared to central facilities that diagnose and monitor the applications. Over the past decades, biosensors have been introduced that offer more reliable, cost-effective, and accurate detection methods. Aptamer-based biosensors have unprecedented advantages over biosensors that use natural receptors such as antibodies and enzymes. In the current epidemic, point-of-care testing (POCT) is advantageous because it is easy to use, more accessible, faster to detect, and has high accuracy and sensitivity, reducing the burden of testing on healthcare systems. POCT is beneficial for daily epidemic control as well as early detection and treatment. This review provides detailed information on the various design strategies and virus detection methods using aptamer-based sensors. In addition, we discussed the importance of different aptamers and their detection principles. Aptasensors with higher sensitivity, specificity, and flexibility are critically discussed to establish simple, cost-effective, and rapid detection methods. POC-based aptasensors’ diagnostic applications are classified and summarised based on infectious and infectious diseases. Finally, the design factors to be considered are outlined to meet the future of rapid POC-based sensors.

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Hepatitis C virus (HCV) diagnosis via microfluidics

Abstract: Several microfluidic techniques for HCV viral diagnosis.

Cited by 21 publications

References 157 publications

A Review of Cyclic Olefin Copolymer Applications in Microfluidics and Microdevices

A Review of Cyclic Olefin Copolymer Applications in Microfluidics and Microdevices

Microfluidic systems for infectious disease diagnostics

Aptamer-based rapid diagnosis for point-of-care application

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