Hepatitis C Virus in Arab World: A State of Concern

Daw, Mohamed A.; Dau, Aghnaya A.

doi:10.1100/2012/719494

Cited by 73 publications

(84 citation statements)

References 80 publications

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“…With the continuing conflict emergencies in several countries and the large refugee and migrant populations, overloading dialysis units and depletion of medical resources is a growing concern [204,205]. These emergencies appear to have led to reuse and sharing of supplies and equipment intended for single usage such as infusion vials and machine filters [205,206].…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of hepatitis C virus among hemodialysis patients in the Middle East and North Africa: systematic syntheses, meta-analyses, and meta-regressions

et al. 2017

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SUMMARYWe aimed to investigate hepatitis C virus (HCV) epidemiology among hemodialysis (HD) patients in the Middle East and North Africa (MENA). Our data source was an HCV biological measures database populated through systematic literature searches. Descriptive epidemiologic syntheses, effects meta-analyses and meta-regressions, and genotype analyses were conducted. We analyzed 289 studies, including 106 463 HD patients. HCV incidence ranged between 0 and 100% as seroconversion risk, and between 0 and 14·7 per 1000 person-years as incidence rate. The regional pooled mean estimate was 29·2% (95% CI: 25·6-32·8%) for HCV antibody positive prevalence and 63·0% (95% CI: 55·4-70·3%) for the viremic rate. Region within MENA, country income group, and year of data collection were associated with HCV prevalence; year of data collection adjusted odds ratio was 0·92 (95% CI: 0·90-0·95). Genotype diversity varied across countries with four genotypes documented regionally: genotype 1 (39·3%), genotype 2 (5·7%), genotype 3 (29·6%), and genotype 4 (25·4%). Our findings showed that one-third of HD patients are HCV antibody positive and one-fifth are chronic carriers and can transmit the infection. However, HCV prevalence is declining. In context of growing HD patient population and increasing HCV treatment availability, it is critical to improve standards of infection control in dialysis and expand treatment coverage.

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Section: Discussionmentioning

confidence: 99%

Epidemiology of hepatitis C virus among hemodialysis patients in the Middle East and North Africa: systematic syntheses, meta-analyses, and meta-regressions

et al. 2017

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“…This failure can be attributed to a group of factors including the bureaucracy and hierarchy among their health systems and education, lack of knowledge, and lack of basic skills [16,17]. HBV and HCV infections are a persistent issue in the entire Arab world, where the average prevalence rate of HBV infection ranges from 2% to more than 8% [18,19], while the prevalence of HCV ranges between 0.4-23% [19]. Prevalence shows great variability from one region to another, and even among countries of the same region.…”

Section: Epidemiology Of Hbv and Hcv Among Pregnant Women In Arab Coumentioning

confidence: 99%

Hepatitis B and C virus infections among pregnant women in Arab and African countries

Gasim

Murad

Adam

2013

J Infect Dev Ctries

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Introduction: The epidemiology of viral hepatitis during pregnancy is of paramount importance for health planners and program managers. Data on viral hepatitis during pregnancy are not readily available in many African and Arab countries. Both regions have their own unique geography, and comprise over 59 states with crossover and interaction of different cultures. Methodology: A systematic electronic search of the published literature was conducted and data on epidemiology and risk factors of maternal hepatitis B virus (HBV) infection and hepatitis C (HCV) infection in Arab and African countries were extracted from relevant studies. Results: The serology of hepatitis viruses varies greatly among these countries, with different viral genotype patterns. Such a variation in prevalence could be explained by the different risk factors involved. Sexual contact, perinatal infection, blood and its derivatives, hemodialysis, intravenous and percutaneous drug use, and occupational, habitual, and social behavior have been identified as risk factors for hepatitis transmission in various settings in these countries. Conclusions: Infection from hepatitis B and C viruses imposes major socioeconomic and even political burdens on such young and dynamic societies. Thus strategies and clear policies of intervention are required to combat the consequences of hepatitis B and C at both the regional and national levels.

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“…It leads to liver cirrhosis or hepatocellular carcinoma and results in high morbidity and mortality. [1][2][3] Nelson et al, 4 compiled data on hepatitis prevalence in intravenous drug users (IDU) and it was observed that 60-80% of IDUs had anti-HCV in 25 countries and about 10.0 million IDUs worldwide might be anti-HCV positive. Numerous studies documented prevalence of hepatitis C infection.…”

Section: Introductionmentioning

confidence: 99%

“…HCV infection inflicts major socioeconomic burdens and effective intervention strategies are mandatory to combat the consequences of hepatitis C at the regional levels. 1,24,25 Incidence estimates are prerequisite to lessen the disease burden, hence preventive and treatment strategies can be implemented with precise objectives set to be attained. Despite increasing reports of HCV infections, its incidence and risk factors in Faisalabad, Pakistan are still obscure.…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of hepatitis C viral infection in Faisalabad, Pakistan: a retrospective study (2010-2012)

Maan¹,

Hussain²,

Jamil³

2015

Afr H. Sci.

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Abstract:Background: Hepatitis viral infections are major health challenge leading to high morbidity and mortality worldwide. Objectives: Although the magnitude of hepatitis in Pakistan has been well documented, information regarding the prevalence of hepatitis C virus (HCV) infection in Faisalabad, Pakistan is scarce. The present retrospective study was undertaken to determine the epidemiology of HCV in Faisalabad, Pakistan. Methods: Between May, 2010 and December, 2012, medical records of 39780 subjects visiting sexually transmitted infections (STIs) clinic, district headquarter (DHQ) hospital, Faisalabad, Pakistan were reviewed. Regression analysis was used to determine independent risk factors Results: HCV prevalence was 21.99%. With mean age of 49.5 ± 2.7 years (range 27-63 years), majority (67.15%) of the individuals were male. Marital status and low literacy rates were associated with HCV (P<0.05). Reference to the potential risk factors, the injection drug use was the major mode (72.77%) of infection transmission. Age (OR 1.5, 95% CI 1.2-1.9), male gender (OR 1.2, 95% CI 0.9-1.6) and injection use (OR 1.9, 95% CI 1.0-2.7) were significantly associated with HCV. Conclusions: Most important finding was higher HCV prevalence in Faisalabad region as compared to the previous assessments that demands an urgent need for preventive intervention strategies.

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Hepatitis C Virus in Arab World: A State of Concern

Cited by 73 publications

References 80 publications

Epidemiology of hepatitis C virus among hemodialysis patients in the Middle East and North Africa: systematic syntheses, meta-analyses, and meta-regressions

Epidemiology of hepatitis C virus among hemodialysis patients in the Middle East and North Africa: systematic syntheses, meta-analyses, and meta-regressions

Hepatitis B and C virus infections among pregnant women in Arab and African countries

Epidemiology of hepatitis C viral infection in Faisalabad, Pakistan: a retrospective study (2010-2012)

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