Hepatitis C Virus Stimulates Low-Density Lipoprotein Receptor Expression To Facilitate Viral Propagation

Syed, Gulam Hussain; Tang, Hanmei; Khan, Mohsin; Hassanein, Tarek; Li, Jingwen; Siddiqui, Aleem

doi:10.1128/jvi.02727-13

Cited by 92 publications

(76 citation statements)

References 44 publications

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“…Cholesterol and LDL depletion in serum was confirmed in our results related to cases of advanced fibrosis and cirrhosis [26]. There have been reports on lipids with regard to advanced liver fibrosis in CHC: of a decrease in TCh and LDL, or in HDL and TG.…”

Section: Discussionsupporting

confidence: 86%

Association of Serum Lipids with Hepatic Steatosis, Stage of Liver Fibrosis and Viral Load in Chronic Hepatitis C

Valkov

Ivanova

Alexiev

et al. 2017

JCDR

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Section: Discussionsupporting

confidence: 86%

Association of Serum Lipids with Hepatic Steatosis, Stage of Liver Fibrosis and Viral Load in Chronic Hepatitis C

Valkov

Ivanova

Alexiev

et al. 2017

JCDR

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“…This allows virus to travel through the bloodstream protected from immune responses and re-enter hepatocytes through LDL receptor. To facilitate expression of LDL-receptors HCV up-regulates SREBP, causing seatosis [44]. …”

Section: Pathogens Target Cellular Cholesterol Metabolismmentioning

confidence: 99%

Interaction of pathogens with host cholesterol metabolism

Sviridov

Bukrinsky

2014

Current Opinion in Lipidology

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Purpose of the review Pathogens of different taxa, from prions to protozoa, target cellular cholesterol metabolism to advance own development and to impair host immune responses, but also causing metabolic complications, e.g. atherosclerosis. This review describes recent findings of how pathogens do it. Recent findings A common theme in interaction between pathogens and host cholesterol metabolism is pathogens targeting lipid rafts of the host plasma membrane. Many intracellular pathogens use rafts as an entry gate, taking advantage of the endocytic machinery and high abundance of outward looking molecules that can be used as receptors. At the same time, disruption of the rafts’ functional capacity, achieved by the pathogens through a number of various means, impairs the ability of the host to generate immune response, thus helping pathogen to thrive. Pathogens cannot synthesise cholesterol, and salvaging host cholesterol helps pathogens build advanced cholesterol-containing membranes and assembly platforms. Impact on cholesterol metabolism is not limited to the infected cells; proteins and miRNAs secreted by infected cells affect lipid metabolism systemically. Summary Given an essential role that host cholesterol metabolism plays in pathogen development, targeting this interaction may be a viable strategy to fight infections as well as metabolic complications of the infections.

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“…Although lower serum levels of TC, LDL-c and HDL-c are commonly reported in treatment naïve CHC patients when compared with those of normal subjects, the literature data on the impact of steatosis on serum lipids levels are limited [2,17,18]. Lipids play an important role in multiple aspects of HCV life cycle as HCV modulates host lipoprotein metabolism to make it more effective for viral proliferation, propagation and persistence [4,19,20]. HCV-associated hypocholesterolemia results from the inhibition of apolipoprotein B 100 secretion and disturbed distal cholesterol synthesis pathway [21].…”

Section: Discussionmentioning

confidence: 99%

A Comparative Analysis of Serum Lipids in Patients with Chronic Hepatitis C, Nonalcoholic Fatty Liver Disease and Healthy Controls

Valkov

Ivanova

Marinova

et al. 2017

Acta Medica Bulgarica

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Hepatitis C Virus Stimulates Low-Density Lipoprotein Receptor Expression To Facilitate Viral Propagation

Cited by 92 publications

References 44 publications

Association of Serum Lipids with Hepatic Steatosis, Stage of Liver Fibrosis and Viral Load in Chronic Hepatitis C

Association of Serum Lipids with Hepatic Steatosis, Stage of Liver Fibrosis and Viral Load in Chronic Hepatitis C

Interaction of pathogens with host cholesterol metabolism

A Comparative Analysis of Serum Lipids in Patients with Chronic Hepatitis C, Nonalcoholic Fatty Liver Disease and Healthy Controls

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