Hepatitis E Diagnosis and Management After Liver, Kidney, or Heart Transplant: A Single-Center Experience

Carter, Maximilian; Solsrud, Kassandra; Yeddula, Sirisha; Fitzmaurice, Mary Grace; Singh, Ashina; Nagai, Shunji; Jafri, Syed-Mohammed

doi:10.1016/j.transproceed.2022.04.025

Cited by 1 publication

(1 citation statement)

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“…5,24 Chronic HEV infection in SOT recipients was defined as HEV replication (viremia) -HEV ribonucleic acid detectable in plasma, for more than 3 months after the onset of infection. 5,25 Furthermore, spontaneous clearance of HEV infection in transplant recipients could occur 3 months after the first detection of HEV viremia. 5,26 However, it was reported that some healthy individuals were HEV positive for more than 6 months.…”

Section: Hev In Solid Organ Transplant (Sot) Recipientsmentioning

confidence: 99%

Hepatitis E Virus (HEV) Infection Among Immunocompromised Individuals: A Brief Narrative Review

Alexandrova,

Tsachev,

Kirov

et al. 2024

IDR

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Hepatitis E virus (HEV) is a single-stranded positive-sense RNA virus that belongs to Hepeviridae family. HEV is the most common cause of acute viral hepatitis worldwide. According to the World Health Organization (WHO), there are estimated 20 million HEV infections worldwide every year, leading to estimated 3.3 million symptomatic cases of HEV infection. The WHO estimates that HEV infection caused approximately 44,000 deaths in 2015, which represents 3.3% of mortality rates due to viral hepatitis. In low-income (LI) countries and lower-middle-income (LMI) countries, HEV is a waterborne infection induced by HEV genotype (gt) 1 and HEV gt 2 that cause large outbreaks and affect young individuals with a high mortality rate in pregnant women from South Asian countries and patients with liver diseases. HEV gt 3, HEV gt 4, and HEV gt 7 are responsible for sporadic infections with zoonotic transmission mainly through the consumption of raw or undercooked meat from different animals. Acute HEV infection is relatively asymptomatic or mild clinical form, in rare cases the disease can be moderate/severe clinical forms and result in fulminant hepatitis or acute liver failure (ALF). Furthermore, HEV infection is associated with extrahepatic manifestations, including renal and neurological clinical signs and symptoms. Pregnant women, infants, older people, immunocompromised individuals, patients with comorbidities, and workers who come into close contact with HEV-infected animals are recognized as major risk groups for severe clinical form of HEV infection and fatal outcome. Chronic HEV infection can occur in immunocompromised individuals with the possibility of progression to cirrhosis.

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