Hepatitis E Virus and the Kidney in Solid-Organ Transplant Patients

Kamar, Nassim; Wéclawiak, Hugo; Guilbeau‐Frugier, Céline; Abravanel, Florence; Cointault, Olivier; Ribes, David; Esposito, Laure; Cardeau-Desangles, Isabelle; Guitard, Joëlle; Sallusto, Fédérico; Muscari, Fabrice; Péron, Jean Marie; Alric, Laurent; Izopet, Jacques; Rostaing, Lionel

doi:10.1097/tp.0b013e318245f14c

Cited by 185 publications

(211 citation statements)

References 19 publications

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“…As with other hepatotropic viruses, HEV1 and -3 infections can cause glomerular disease. Two different histological patterns of glomerular disease have been observed: membrano-proliferative and membranous glomerulonephritis (44). These kidney injuries were observed in immunocompetent patients (45) as well as kidney and liver transplant patients (44).…”

Section: Extrahepatic Manifestations Of Hevmentioning

confidence: 98%

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Hepatitis E Virus Infection

et al. 2014

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SUMMARY Hepatitis E virus (HEV) infection is a worldwide disease. An improved understanding of the natural history of HEV infection has been achieved within the last decade. Several reservoirs and transmission modes have been identified. Hepatitis E is an underdiagnosed disease, in part due to the use of serological assays with low sensitivity. However, diagnostic tools, including nucleic acid-based tests, have been improved. The epidemiology and clinical features of hepatitis E differ between developing and developed countries. HEV infection is usually an acute self-limiting disease, but in developed countries it causes chronic infection with rapidly progressive cirrhosis in organ transplant recipients, patients with hematological malignancy requiring chemotherapy, and individuals with HIV. HEV also causes extrahepatic manifestations, including a number of neurological syndromes and renal injury. Acute infection usually requires no treatment, but chronic infection should be treated by reducing immunosuppression in transplant patients and/or the use of antiviral therapy. In this comprehensive review, we summarize the current knowledge about the virus itself, as well as the epidemiology, diagnostics, natural history, and management of HEV infection in developing and developed countries.

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Section: Extrahepatic Manifestations Of Hevmentioning

confidence: 98%

“…Impaired renal function has been noted in both acute and chronic HEV infections (43,44). As with other hepatotropic viruses, HEV1 and -3 infections can cause glomerular disease.…”

Section: Extrahepatic Manifestations Of Hevmentioning

confidence: 99%

Hepatitis E Virus Infection

et al. 2014

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“…102,103 In addition, glomerular lesions, such as membrano-proliferative glomerulonephritis and membranous glomerulonephritis, have been reported in kidney-and liver-transplant patients. 104 Furthermore, cryoglobulinemia has been detected in transplant patients with chronic HEV-3 infection.…”

Section: Kidney Manifestationsmentioning

confidence: 99%

Chronic Hepatitis E Virus Infection and Treatment

Kamar

Izopet

Dalton

2013

Journal of Clinical and Experimental Hepatology

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“…Membranoproliferative glomerulonephritis and relapses in IgA nephropathy were noted in solid organ transplant recipients with acute and chronic HEV infection [33] . Cryoglobulinemia was also noted in 70% of these patients, with complete resolution following therapy with ribavirin.…”

Section: Extra Hepatic Manifestations Of Chronic Hepatitis Ementioning

confidence: 99%

Chronic hepatitis E: A brief review

Murali

Kotwal

Chawla

2015

WJH

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Hepatitis E viral infection has traditionally been considered an acute, self-limited, water borne disease similar to hepatitis A, endemic to developing countries. However, over the past decade, zoonotic transmission and progression to chronicity in human patients has been identified, resulting in persistently elevated transaminase levels, progressive liver injury and cirrhosis. In addition to liver injury, neurological, renal and rheumatological manifestations have also been reported. Chronic hepatitis E occurs mainly in immunosuppressed individuals such as transplant recipients, human immunodeficiency virus patients with low CD4 counts and in patients with hematological malignancies receiving chemotherapy. Diagnosis is established by persistent elevation of hepatitis E virus RNA in the stool or serum. This population often requires treatment with antiviral agents, particularly ribavirin, as spontaneous clearance with reduction in immunosuppression occurs only in about a third of the patients. The purpose of this review, is to further discuss the clinical presentation, and recent advances in diagnosis, treatment and prophylaxis of chronic hepatitis E.

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Hepatitis E Virus and the Kidney in Solid-Organ Transplant Patients

Abstract: HEV-associated glomerulonephritis seems to be an HEV-related extrahepatic manifestation. Further studies are required to confirm these observations.

Cited by 185 publications

References 19 publications

Hepatitis E Virus Infection

Hepatitis E Virus Infection

Chronic Hepatitis E Virus Infection and Treatment

Chronic hepatitis E: A brief review

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