Hepatitis E Virus Infection in Lung Transplant Recipients: A Case Series

Ambrocio, Gene Philip Louie; Aguado, Silvia; Carrillo, Javier; Laporta, Rosalía; Lazaro-Carrasco, M.; Avellón, Ana; Arán-Tohá, G.; Ussetti, M.; Aguilar, Myriam

doi:10.1016/j.transproceed.2018.10.006

Cited by 8 publications

(4 citation statements)

References 25 publications

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“…Studies focused on transplant recipients in the Iberian Peninsula have identified HEV-3 and also anti-HEV IgM/IgG in renal, liver, lung and other solid organ transplant recipients (Ambrocio et al, 2019 ; Breda et al, 2014 ; Carmo et al, 2016 ; Lens et al, 2015 ; Senosiain et al, 2016 ). Knowing that HEV-3 infection may progress into a chronic hepatitis in immunosuppressed patients (Wang & Meng, 2021 ), HEV diagnosis in these type of patients should be carried out since they can benefit from ribavirin treatment (Correia et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Hepatitis E Virus in the Iberian Peninsula: A Systematic Review

et al. 2023

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One of the most frequent causes of acute viral hepatitis is hepatitis E virus (HEV) causing 20 million infections worldwide each year and 44,000 deaths. Studies on HEV in the Iberian Peninsula have been increasing through time with HEV infection being identified in humans and animals. The aim of the present systematic review was to compile and evaluate all the published data on HEV from studies performed in humans, animals and environmental samples in the Iberian Peninsula. The electronic databases Mendeley, PubMed, Scopus, and Web of Science were thoroughly searched, and research published up until February 01, 2023 were included. Resulting in a total of 151 eligible papers by full reading and application of PRISMA exclusion/inclusion criteria. Overall, the present review shows that several HEV genotypes, namely HEV-1, 3, 4, and 6 as well as Rocahepevirus, are circulating in humans, animals, and in the environment in the Iberian Peninsula. HEV-3 was the most common genotype circulating in humans in Portugal and Spain, as expected for developed countries, with HEV-1 only being detected in travelers and emigrants from HEV endemic regions. Spain is the biggest pork producer in Europe and given the high circulation of HEV in pigs, with HEV-3 being primarily associated to zoonotic transmission through consumption of swine meat and meat products, in our opinion, the introduction of an HEV surveillance system in swine and inclusion of HEV in diagnostic routines for acute and chronic human hepatitis would be important. Additionally, we propose that establishing a monitoring mechanism for HEV is crucial in order to gain a comprehensive understanding of the prevalence of this illness and the various strains present in the Iberian Peninsula, as well as their potential impact on public health.

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Section: Discussionmentioning

confidence: 99%

Hepatitis E Virus in the Iberian Peninsula: A Systematic Review

et al. 2023

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“…A wide variety of factors cause ALF (Table 1) [23][24][25]. The most common causes of this disease are viral infections and drug-induced liver inflammation.…”

Section: Etiologymentioning

confidence: 99%

Perspective of placenta derived mesenchymal stem cells in acute liver failure

et al. 2020

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Acute Liver failure (ALF) is a life-threatening disease and is determined by coagulopathy (with INR ≥ 1.5) and hepatic encephalopathy as a result of severe liver injury in patients without preexisting liver disease. Since there are problems with liver transplantation including lack of donors, use of immunosuppressive drugs, and high costs of this process, new therapeutic approaches alongside current treatments are needed. The placenta is a tissue that is normally discarded after childbirth. On the other hand, human placenta is a rich source of mesenchymal stem cells (MSCs), which is easily available, without moral problems, and its derived cells are less affected by age and environmental factors. Therefore, placenta-derived mesenchymal stem cells (PD-MSCs) can be considered as an allogeneic source for liver disease. Considering the studies on MSCs and their effects on various diseases, it can be stated that MSCs are among the most important agents to be used for novel future therapies of liver diseases. In this paper, we will investigate the effects of mesenchymal stem cells through migration and immigration to the site of injury, cell-to-cell contact, immunomodulatory effects, and secretory factors in ALF.

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“…Infection may be either donor-derived or acquired posttransplant. Although primarily reported in liver and kidney transplant recipients [81,82], reports of HEV infection in lung transplantation exist [83]. Although routine screening is not currently recommended, the diagnosis should be considered in transplant recipients with unexplained hepatitis or cirrhosis.…”

Section: Hepatitis E Virusmentioning

confidence: 99%

Screening of donors and recipients for infections prior to solid organ transplantation

Nanayakkara

Schaenman²

2019

Current Opinion in Organ Transplantation

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Purpose of reviewThis review is a brief overview of current guidelines on screening donors and candidates for bacterial, fungal, parasitic and viral infections prior to solid organ transplantation. The pretransplant period is an important time to evaluate infection exposure risk based on social history as well as to offer vaccinations. Recent findingsOne of the major changes in the past few years has been increased utilization of increased Public Health Service risk, HIV positive, and hepatitis C-positive donors. There has also been increased attention to donor and recipient risks for geographically associated infections, such as endemic fungal infections and flaviviruses. SummaryScreening for donors and candidates prior to organ transplantation can identify and address infection risks. Diagnosing infections in a timely manner can help guide treatment and additional testing. Use of necessary prophylactic treatment in organ recipients can prevent reactivation of latent infections and improve posttransplant outcomes.

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Hepatitis E Virus Infection in Lung Transplant Recipients: A Case Series

Cited by 8 publications

References 25 publications

Hepatitis E Virus in the Iberian Peninsula: A Systematic Review

Hepatitis E Virus in the Iberian Peninsula: A Systematic Review

Perspective of placenta derived mesenchymal stem cells in acute liver failure

Screening of donors and recipients for infections prior to solid organ transplantation

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