Hepatitis E Virus Seroprevalence and Associated Risk Factors in Pregnant Women Attending Antenatal Consultations in Senegal

Diouara, Abou Abdallah Malick; Lo, Seynabou; Nguer, Cheikh Momar; Senghor, Assane; Diop-Ndiaye, Halimatou; Manga, N.M.; Danfakha, Fodé; Diallo, S.; Dieme, Marie Edouard Faye; Thiam, Ousmane; Biaye, Babacar; Manga, Ndèye Marie Pascaline; Thiam, Fatou; Sarr, Habibou; Lô, Gora; Ndour, Momar; Manga, Sébastien Paterne; Diaby, Nouhou; Dieng, Modou; Diop, Idy; Dièye, Yakhya; Kane, Coumba Touré; Peeters, Martine; Ayouba, Ahidjo

doi:10.20944/preprints202206.0096.v1

Cited by 2 publications

(1 citation statement)

References 29 publications

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“…The enrollment of participants was carried out from March to July 2021 at the regional hospital of Saint-Louis (Senegal). Socio-demographic characteristics and inclusion criteria of the participants were fully described (Viruses 2022, 14, 1742. https://doi.org/10.3390/v14081742) (Diouara et al, 2022). The free and informed consent of the pregnant women was obtained verbally, individually.…”

Section: Methodsmentioning

confidence: 99%

COVID-19 and pregnancy: Investigation of serological markers and associated factors

Lo¹,

Dièye²,

Abou³

et al. 2023

Afr. J. Microbiol. Res.

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COVID-19 is a major public health emergency that has recently shaken the world. Pregnant women have not been spared from this pandemic. Although there is no clinical difference between them and the general population, pregnant women are at increased risk of developing severe forms and pregnancyrelated complications. The objective of this study was to investigate the presence of anti-SARS-CoV-2 antibodies and to identify associated factors in pregnant women followed at the Regional Hospital Center (CHR) of Saint-Louis, Senegal. A cross-sectional, prospective and descriptive study was conducted among 400 pregnant women followed at the Saint-Louis Regional Hospital (Senegal) over a five-month period from March to July, 2021. None of the patients had received an anti-COVID-19 vaccine. Determination of anti-SARS-CoV-2 antibodies was performed by the Healgen IgG/IgM SARS-CoV-2 qualitative rapid test. 400 pregnant women were included in the study. The mean age was 27.8 years (±6.3). The most representative age group was between 25 and 29 years with 29%. The majority of patients (76.8%) were housewives. Only 41 patients (10.3%) had travelled outside Saint-Louis (Senegal) in the previous 6 months. None of the patients had received anti-COVID-19 vaccine. Anti-SARS-CoV-2 antibody testing was positive in 232 cases (58%). IgG anti-SARS-CoV-2 antibodies were present in all the 232 women (100%) and IgM was in 6 cases (2.6%). The study showed a high seroprevalence of anti-SARS-CoV-2 in pregnant women followed at the Saint-Louis Regional Hospital (Senegal) showing a large underestimation of the pandemic in that population. Further evaluation on the role of SRAS-CoV-2 antibodies in the protection against the virus or outcome of pregnancy women need to be investigated on a larger size of pregnant women.

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Section: Methodsmentioning

confidence: 99%

COVID-19 and pregnancy: Investigation of serological markers and associated factors

Lo¹,

Dièye²,

Abou³

et al. 2023

Afr. J. Microbiol. Res.

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Detection of Hepatitis E Virus (HEV) in Pork Sold in Saint-Louis, the North of Senegal

Tene,

Diouara,

Kane

et al. 2024

Life

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The hepatitis E virus (HEV) is a zoonotic pathogen with various hosts, including pigs, which act as reservoirs. In industrialized countries, sporadic cases caused by genotype 3, contracted by ingesting contaminated uncooked or undercooked meat, have been reported. However, in developing countries, HEV infection is mainly dominated by genotype 2 and often associated with poor hygiene conditions and drinking water supplies. HEV infection and its circulation in domestic fauna in West Africa are poorly documented. This study aimed to assess the presence of HEV in pork sold in Saint-Louis, Senegal. Meat products (250 g samples, n = 74) were purchased in August 2022 from three locations. Then, 2 g/sample was minced to extract total nucleic acids using the Purelink™ Viral DNA/RNA kit. RT-PCR reactions were performed using the One-Taq™ One-Step RT-PCR kit targeting the HEV ORF2 genomic region. The products obtained were visualized on a 1% agarose gel. Of a total of 74 samples, divided into pork meat (n = 65) and pork liver (n = 9), 5.4% (n = 4) tested positive for HEV. In both cases, two samples were positive, representing a rate of 3.1% and 22.2% for meat and pork liver, respectively. All new viral sequences were obtained from a monophyletic group within HEV genotype 3. This study is the first to report the presence of HEV in pork sold in Senegal and the results reveal a potential circulation of HEV in the pig population. The high proportion of contamination in the pork liver samples highlights a major risk associated with their consumption.

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Hepatitis E Virus Seroprevalence and Associated Risk Factors in Pregnant Women Attending Antenatal Consultations in Senegal

Cited by 2 publications

References 29 publications

COVID-19 and pregnancy: Investigation of serological markers and associated factors

COVID-19 and pregnancy: Investigation of serological markers and associated factors

Detection of Hepatitis E Virus (HEV) in Pork Sold in Saint-Louis, the North of Senegal

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