Hepato Renal Protective Effect of Origanum Majorana against Adverse Effect of Ivermectin in Rabbits

Abstract

The current study looked at the hepatic-renal protection of Origanum majorana "O.M" leaves extract in male rabbits against the negative effects of ivermectin. Twenty male rabbits were used and divided into four groups each group contain 5 rabbits as a following: Group one: rabbits which served as negative control were orally administered distilled water for 60 consecutive days. Group two: The rabbits in this group were given an aqueous extract of O.M. orally (200 milligrams per kilogram of body weight), once daily for 60 consecutive days. Group three: rabbits in this group received a subcutaneous therapeutic dose of ivermectin (200 micrograms per kilogram body weight), once monthly for 2 consecutive months. Group four: This group of rabbits was given an orally aqueous extract of O.M. (200 milligrams per kilogram of body weight) once daily for sixty consecutive days. and a subcutaneous therapeutic dose of ivermectin (200 micrograms per kilogram of body weight), once monthly for 2 consecutive months. The degree of hepatic protection was measured using liver enzymes activities (Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), alkaline phosphatase (ALP), g-Glutamyl transferase (GGT) and total bilirubin, also the levels of Cholesterol, Triglycerides, HDL-cholesterol, LDL-cholesterol and VLDL-cholesterol were also estimated. The degree of renal protection was measured using creatinine, urea, sodium, potassium, also the levels of total protein, Albumin and Globulin were quantitated also the histo-pathological examination of the liver, kidneys were done. Results showed that the administration of O.M. extract restored the severely disrupted liver and kidney functions caused by ivermectin's unfavorable effect to almost normal levels as well as the co-administration of O.M. extract significantly reduced the histopathological effect of ivermectin on the liver and kidney. From our findings we concluded that the O.M. aqueous extract possessed a hepato-renal protective effect against ivermectin-induced adverse effects in rabbits.

Struggling Thermal Stress Impacts on Growth Performance and Health Status of Newly Weaned Rabbits Using Nanoemulsion of Origanum majorana Considering the Economic Efficiency of Supplementation

“…Marjoram essential oil alleviated the renal damages induced by ivermectin [21] via levitation antioxidant capabilities, lessening inflammation in rabbits. Moreover, Origanum majorana has beneficial effects on feed efficiency, antioxidant abilities, growth indices, and immunological reactions in lamb and fish [22][23][24][25].…”