Hepatocyte Growth Factor in Saliva of Patients with Renal Failure and Periodontal Disease

Wilczyńska-Borawska, Magdalena; Borawski, Jacek; Bagińska, Joanna; Małyszko, Jolanta; Myśliwiec, Michał

doi:10.3109/0886022x.2012.696510

Cited by 9 publications

(6 citation statements)

References 36 publications

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“…Exceptionally, 3 independent studies demonstrated significant association of salivary HGF with periodontitis [119–122] which is consistent with similar data analysing GCF [123]. In terms of function, HGF is known to be involved in dental development [124] but, significantly, HGF is secreted by gingival fibroblasts and HGF secretion is regulated by cytokines and bacterial products; it has been hypothesised that HGF may mediate epithelial apical migration in periodontitis [124, 125].…”

Section: Protein Biomarkers Of Periodontitis: Candidate Protein Stsupporting

confidence: 63%

Protein Biomarkers of Periodontitis in Saliva

Taylor

2014

ISRN Inflammation

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Periodontitis is a chronic inflammatory condition of the tissues that surround and support the teeth and is initiated by inappropriate and excessive immune responses to bacteria in subgingival dental plaque leading to loss of the integrity of the periodontium, compromised tooth function, and eventually tooth loss. Periodontitis is an economically important disease as it is time-consuming and expensive to treat. Periodontitis has a worldwide prevalence of 5–15% and the prevalence of severe disease in western populations has increased in recent decades. Furthermore, periodontitis is more common in smokers, in obesity, in people with diabetes, and in heart disease patients although the pathogenic processes underpinning these links are, as yet, poorly understood. Diagnosis and monitoring of periodontitis rely on traditional clinical examinations which are inadequate to predict patient susceptibility, disease activity, and response to treatment. Studies of the immunopathogenesis of periodontitis and analysis of mediators in saliva have allowed the identification of many potentially useful biomarkers. Convenient measurement of these biomarkers using chairside analytical devices could form the basis for diagnostic tests which will aid the clinician and the patient in periodontitis management; this review will summarise this field and will identify the experimental, technical, and clinical issues that remain to be addressed before such tests can be implemented.

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Section: Protein Biomarkers Of Periodontitis: Candidate Protein Stsupporting

confidence: 63%

Protein Biomarkers of Periodontitis in Saliva

Taylor

2014

ISRN Inflammation

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“…Oshima et al reported that these pleiotropic properties of HGF might be involved in the development and progression of periodontal diseases [19,20,21]. Previously, Wilczynska-Borawska et al [22] showed that there was no difference in HGF levels in the saliva of HD, PD, and chronic renal failure patients, although the levels in the saliva of periodontitis patients were higher than those in the healthy population. In PD patients specifically, significant and positive correlations between HGF levels in the saliva and plaque index (PI), papillary bleeding index (PBI), and gingival index (GI) have been reported.…”

Section: Peritoneal Dialysismentioning

confidence: 99%

“…Several studies have investigated the effects of periodontal therapy in PD patients [5,22]. Briefly, treatment of periodontal disease improved periodontal status, inflammatory markers, and nutrition status [5].…”

Section: Peritoneal Dialysismentioning

confidence: 99%

“…reported that plaque and calculus accumulation in the HD and PD groups were higher than in controls. However, gingival inflammation in PD patients was significantly lower than in HD patients [22,68,90]. Moreover, the SFR in the PD group was significantly higher than that in the HD group, although both groups had significantly lower values than the control group [68].…”

Section: Hemodialysismentioning

confidence: 99%

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Periodontal Disease in Patients Receiving Dialysis

Miyata

Obata

Mochizuki

et al. 2019

IJMS

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Chronic kidney disease (CKD) is characterized by kidney damage with proteinuria, hematuria, and progressive loss of kidney function. The final stage of CKD is known as end-stage renal disease, which usually indicates that approximately 90% of normal renal function is lost, and necessitates renal replacement therapy for survival. The most widespread renal replacement therapy is dialysis, which includes peritoneal dialysis (PD) and hemodialysis (HD). However, despite the development of novel medical instruments and agents, both dialysis procedures have complications and disadvantages, such as cardiovascular disease due to excessive blood fluid and infections caused by impaired immunity. Periodontal disease is chronic inflammation induced by various pathogens and its frequency and severity in patients undergoing dialysis are higher compared to those in healthy individuals. Therefore, several investigators have paid special attention to the impact of periodontal disease on inflammation-, nutrient-, and bone metabolism-related markers; the immune system; and complications in patients undergoing dialysis. Furthermore, the influence of diabetes on the prevalence and severity of manifestations of periodontal disease, and the properties of saliva in HD patients with periodontitis have been reported. Conversely, there are few reviews discussing periodontal disease in patients with dialysis. In this review, we discuss the available studies and review the pathological roles and clinical significance of periodontal disease in patients receiving PD or HD. In addition, this review underlines the importance of oral health and adequate periodontal treatment to maintain quality of life and prolong survival in these patients.

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“…Available data on the association of salivary growth factors with PD are limited and imprecise. On the other hand, hepatocyte growth factor (HGF) has been related to PD as a possible mediator of apical epithelial migration [ 98 , 99 , 100 ].…”

Section: Biomarkers In Saliva In Different Oral Diseasesmentioning

confidence: 99%

Salivary Biomarkers and Their Application in the Diagnosis and Monitoring of the Most Common Oral Pathologies

Melguizo‐Rodríguez

Costela‐Ruiz

Manzano-Moreno

et al. 2020

IJMS

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Saliva is a highly versatile biological fluid that is easy to gather in a non-invasive manner—and the results of its analysis complement clinical and histopathological findings in the diagnosis of multiple diseases. The objective of this review was to offer an update on the contribution of salivary biomarkers to the diagnosis and prognosis of diseases of the oral cavity, including oral lichen planus, periodontitis, Sjögren’s syndrome, oral leukoplakia, peri-implantitis, and medication-related osteonecrosis of the jaw. Salivary biomarkers such as interleukins, growth factors, enzymes, and other biomolecules have proven useful in the diagnosis and follow-up of these diseases, facilitating the early evaluation of malignization risk and the monitoring of disease progression and response to treatment. However, further studies are required to identify new biomarkers and verify their reported role in the diagnosis and/or prognosis of oral diseases.

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Hepatocyte Growth Factor in Saliva of Patients with Renal Failure and Periodontal Disease

Cited by 9 publications

References 36 publications

Protein Biomarkers of Periodontitis in Saliva

Protein Biomarkers of Periodontitis in Saliva

Periodontal Disease in Patients Receiving Dialysis

Salivary Biomarkers and Their Application in the Diagnosis and Monitoring of the Most Common Oral Pathologies

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