2022
DOI: 10.3390/ijms23063356
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Hepatocyte Proteome Alterations Induced by Individual and Combinations of Common Free Fatty Acids

Abstract: Non-alcoholic fatty liver disease is a pathology with a hard-to-detect onset and is estimated to be present in a quarter of the adult human population. To improve our understanding of the development of non-alcoholic fatty liver disease, we treated a human hepatoma cell line model, HepG2, with increasing concentrations of common fatty acids, namely myristic, palmitic and oleic acid. To reproduce more physiologically representative conditions, we also included combinations of these fatty acids and monitored the… Show more

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Cited by 3 publications
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“…Various lipidsoluble compounds, especially free fatty acids (FFAs), play significant roles in mammalian bodies and are involved in many diseases or disorders, such as cancers, fever, pain, and bipolar disorders. [9][10][11][12][13][14] However, their measurement in a single cell is not always easy due to the small amounts of these substances, the presence of isomers, and the complex sample preparation procedures.…”
Section: Introductionmentioning
confidence: 99%
“…Various lipidsoluble compounds, especially free fatty acids (FFAs), play significant roles in mammalian bodies and are involved in many diseases or disorders, such as cancers, fever, pain, and bipolar disorders. [9][10][11][12][13][14] However, their measurement in a single cell is not always easy due to the small amounts of these substances, the presence of isomers, and the complex sample preparation procedures.…”
Section: Introductionmentioning
confidence: 99%