Hepatology Highlights

Suri, Jaspreet S.; Ezaz, Ghideon; Lau, Daryl T.Y.; Kulai, Tasha; Malhi, Harmeet; Tafesh, Zaid H.; Fortune, Brett E.; Rosenblatt, Russell; Brown, Robert S.; Pisa, Joseph F.; Russo, Nicholas; Hirsova, Petra; Schwartz, Robert E.; Aseem, Sayed Obaidullah; Jalan‐Sakrikar, Nidhi; Gupta, Vikas

doi:10.1002/hep.30775

Cited by 1 publication

(1 citation statement)

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“…VD3 has been suggested to function as a putative multitargeting molecule because of its ability to have extraskeletal effects in many tissues, including the skin [25]. It has been reported that the expression of carbonic anhydrase II and IX are significantly upregulated in keratinocytes by VD3 treatment [26]. In addition, VD3 is useful for psoriasis treatment [27].…”

Section: Discussionmentioning

confidence: 99%

A Role for Neutral Sphingomyelinase in Wound Healing Induced by Keratinocyte Proliferation upon 1α, 25-Dihydroxyvitamin D3 Treatment

Patria

Ceccarini

Codini

et al. 2019

IJMS

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The skin has many functions, such as providing a barrier against injury and pathogens, protecting from ultraviolet light, and regulating body temperature. Mechanical causes and many different pathologies can lead to skin damage. Therefore, it is important for the skin to be always adaptable and renewable and for cells to undergo proliferation. Here, we demonstrate that 1α, 25-dihydroxyvitamin D3 (VD3) stimulates keratinocyte proliferation, leading to wound closure in a simulation model of injury. Functionally, our results show that VD3 acts by stimulating cyclin D1, a cyclin that promotes the G1/S transition of the cell cycle. The study on the mechanism underlying cyclin D1 expression upon VD3 stimulation clearly demonstrates a key role of neutral sphingomyelinase. The enzyme, whose gene and protein expression is stimulated by VD3, is itself able to induce effects on cyclin D1 and wound healing similar to those obtained with VD3. These results could be very useful in the future to better understand wound mechanisms and improve therapeutic interventions.

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Section: Discussionmentioning

confidence: 99%