Hepatoprotection by a Pgi2 Analogue in Complete Warm Ischemia of the Pig Liver

Kim, Yang-Il; Kai, Tetsuji; Kitano, Seigo; Ishii, Takahiro; Tatsuma, T.; Kamada, Nanao; Sugimachi, Keizō

doi:10.1097/00007890-199410270-00002

Cited by 14 publications

(10 citation statements)

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“…Although the main goal during major liver surgery is to keep the ischemia period as short as possible, investigations still continue to prevent or diminish this demoralizing injury [13,14]. Among several pharmacological agents that have been proven to be useful in the prevention or treatment of hepatic I/R injury [15,16], much attention has been focused on PTX. In the liver, PTX has been shown to increase hepatic surface oxygenation and restore hepatocellular function after ischemia [7].…”

Section: Discussionmentioning

confidence: 99%

Pentoxifylline Contributes to the Hepatic Cytoprotective Process in Rats Undergoing Hepatic Ischemia and Reperfusion Injury

Aslan

Karagüzel²,

Çelik³

et al. 2001

Eur Surg Res

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Aim: Considerable efforts have been made to find and/or eliminate the underyling causes of hepatic ischemia-reperfusion injury, but many points are still unclear. Pentoxifylline-related cytoprotection is one of these unclear points. Our study tests the effects of pentoxifylline on the hepatic cytoprotective process in an experimental model. Materials and Methods: The animals were divided into two groups: (1) placebo-pretreated rats and (2) pentoxifylline-pretreated rats. After pretreatment, all rats underwent the hepatic ischemia-reperfusion procedure which was performed by clamping the hepatoduodenal ligament. To evaluate the liver injury, serum levels of alanine transaminase (ALT) and aspartate transaminase (AST), and liver tissue levels of prostaglandin E₂ (PGE₂) were measured before ischemia, immediately after ischemia and immediately after reperfusion. Results: Before ischemia and immediately after ischemia, there were no significant differences between ALT and AST levels of groups 1 and 2 (p >0.05). However, at the end of reperfusion, ALT and AST levels of group 2 were significantly decreased when compared with group 1 (p < 0.05 and p < 0.01, respectively). Additionally, tissue levels of PGE₂ that were obtained before ischemia, immediately after ischemia and immediately after reperfusion in group 2 were significantly higher than those of group 1 (p < 0.001). Conclusion: Pentoxifylline reduces reperfusion injury of the liver through significantly decreased transaminase levels, and contributes to hepatic cytoprotection by increasing tissue levels of PGE₂ significantly. These effects reflect the role of tissue PGE₂ in pentoxifylline-related hepatoprotection against ischemia-reperfusion injury of the liver.

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Section: Discussionmentioning

confidence: 99%

Pentoxifylline Contributes to the Hepatic Cytoprotective Process in Rats Undergoing Hepatic Ischemia and Reperfusion Injury

Aslan

Karagüzel²,

Çelik³

et al. 2001

Eur Surg Res

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“…A pig model was also used to investigate the role of PGI‐2 in warm liver I/R injury. Liver injury was ameliorated in pigs treated with a PGI‐2 analog which caused a significant improvement in 7‐day survival rate and amelioration of serum transaminase activities 22 …”

Section: Inflammatory Mediators and Targeted Therapies For Liver I/r mentioning

confidence: 99%

Hepatic ischemia–reperfusion injury and therapeutic strategies to alleviate cellular damage

Doğan

Aslan

2011

Hepatology Research

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Warm hepatic ischemia-reperfusion injury is a significant medical problem in many clinical conditions such as liver transplantation, hepatic surgery for tumor excision, trauma and hepatic failure after hemorrhagic shock. Partial or, mostly, total interruption of hepatic blood flow is often necessary when liver surgery is performed. This interruption of blood flow is termed "warm ischemia" and upon revascularization, when molecular oxygen is reintroduced, the organ undergoes a process called "reperfusion injury" that causes deterioration of organ function. Ischemia reperfusion results in cellular damage and tissue injury associated with a complex series of events. Pathophysiological mechanisms leading to tissue injury following ischemia-reperfusion will be discussed and therapies targeted to reduce liver damage will be summarized within this review.

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“…47 Administration of PGI 2 analogues, which counteract the action of TXA 2 in vasoconstrictive and platelet-aggregating effects, also showed hepatoprotective effects in the hepatic ischemia-reperfusion model. 51,52 Hepatic Resection. Circulating TXB 2 levels are remarkably increased during and after hepatic resection, 53 and inhibition of TXA 2 synthesis substantially reduces hepatic damage after hepatectomy.…”

Section: Ischemia-reperfusion-induced Hepatic Injurymentioning

confidence: 99%