Hepcidin modulation in human diseases: From research to clinic

Piperno, Alberto; Mariani, Raffaella; Trombini, Paola; Girelli, Domenico

doi:10.3748/wjg.15.538

Cited by 100 publications

(103 citation statements)

References 114 publications

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“…The diagnosis of ID is quite challenging, 14 and the regulation of iron absorption is complex. 15,16 This complexity requires multiple measures of iron status to determine iron sufficiency. Although clinicians typically use hemoglobin (Hgb), a measure of anemia, as a way to monitor iron status, iron stores become deficient before a decrease in Hgb.…”

Section: Discussionmentioning

confidence: 99%

Iron Status in Children With Autism Spectrum Disorder

et al. 2012

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BACKGROUND AND OBJECTIVES Children with autism spectrum disorders (ASDs) often have food selectivity and restricted diets, putting them at risk for nutritional deficiencies. Previous studies have demonstrated a high prevalence of iron deficiency (ID) in children with ASDs living in Wales, Canada, and Turkey. The objectives of this study were to determine the prevalence of ID and the adequacy of iron intake in children with ASD in the United States. METHODS Participants (age 2–11 years recruited from the Autism Treatment Network Diet and Nutrition Study) completed a 3-day diet record (n = 368) and had laboratory measures of serum ferritin (SF), complete blood count, iron, total iron binding capacity, and transferrin saturation (TS) (n = 222). RESULTS Of the 222 participants with laboratory data, 18 (8%) had SF <12 µg/L and 2 (1%) had ID defined by both low SF and TS (3 children with low SF had missing TS data). One subject had iron deficiency anemia. Fewer than 2% of subjects had iron intake below the estimated average requirement. CONCLUSIONS Although the determination of iron status is complex, these data do not support previous reports that children with ASD are at greater risk for ID than the general population; however, 8% percent of the sample did demonstrate low SF despite <2% of the sample demonstrating iron intake below the estimated average requirement. The prevalence of low SF may be an underestimate, because SF is an acute phase reactant and the study included no measure of inflammation.

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Section: Discussionmentioning

confidence: 99%

Iron Status in Children With Autism Spectrum Disorder

et al. 2012

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“…A pesar de la importancia de la hepcidina para la homeostasis del hierro y enfermedades relacionadas, las metodologías utilizadas para la medición de las concentraciones fisiológicamente relevantes han sido engorrosas y muy limitada su disponibilidad para la investigación clínica (20)(21)(22).…”

Section: Introductionunclassified

Hepcidina y parámetros del hierro en donantes de sangre

Murillo-Ramos

Hurtado-Florez²,

Arciniegas-Yampuezán³

et al. 2016

CES Med

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ResumenIntroducción: la hepcidina es la principal hormona peptídica reguladora de la absorción y distribución tisular del hierro. Estudios recientes han planteado la posibilidad de utilizarla como un biomarcador para evaluar el metabolismo del hierro y sus posibles alteraciones. Aunque, ante la escasa información sobre las propiedades diagnósticas de la hepcidina sérica, no han sido bien caracterizadas y no se cuenta con estudios suficientes en individuos sanos, e incluso en Colombia hasta el momento no se ha realizado ningún estudio referente al tema. Objetivo: estimar las concentraciones de la hepcidina sérica, su rango de normalidad y su correlación con parámetros bioquímicos asociados al metabolismo del hierro en una población de donantes. Materiales y métodos: estudio descriptivo transversal que incluyó 85 donantes, a quienes se les realizó hemograma automatizado, se evaluó ferritina, transferrina y hierro total, mediante los mé-todos de electroquimioluminiscencia, inmunoturbidimetría y colorimetría. La determinación de hepcidina en suero se realizó por medio de una ELISA competitiva. Se utilizaron pruebas estadísticas, con un nivel de significancia de p< 0,05. Resultados: se observaron diferencias significativas en la concentración de hepcidina entre hombres y mujeres. La edad no fue un factor determinante de las concentraciones de hepcidina en los hombres Mediana (Me)=5,73 nM. Solo ferritina se correlacionó fuertemente con la hepcidina. El rango de normalidad de hepcidina encontrado en hombres estuvo entre 1,71 y 13,3 nM y entre 1,67 a 11,3 nM en mujeres. Conclusión: el nivel de hepcidina sérica es mayor en hombres y demuestra la fuerte asociación in vivo con los niveles de hepcidina sérica con el hierro de reserva y circulante.Palabras claves: Metabolismo del hierro, Hepcidina, Ferritina , Transferrina, Hierro total. AbstractIntroduction: The hepatic peptide hormone hepcidin is the principal regulator of iron absorption and tissue iron distribution. Recent studies have proposed hepcidin as a suitable biomarker to assess iron metabolism and its failures. Although the data were limited to information on the diagnostic properties of serum hepcidin, have not been well characterized and neither have enough studies in healthy individuals, and even in Colombia so far have not been any studies on the topic. Objective: quantify the concentra-

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“…Iron homeostasis is regulated by two main mechanisms: an intracellular mechanism, dependent on the amount of iron available for the cell, and a systemic mechanism, in which hepcidin plays a crucial role 20,28 .…”

Section: Hepcidin Expression Related To Iron Deficiency Anemiamentioning

confidence: 99%