Her-2 Oncoprotein Expression in Urothelial Carcinoma

Abstract

BACKGROUNDLow grade non-muscle invasive transitional cell carcinoma is associated with repeated recurrences and progression to high grade tumour. Non-muscle invasive transitional cell carcinoma is associated with poor oncological outcome. Therefore, this study was undertaken to evaluate the expression of HER-2 oncoprotein in transitional cell carcinoma and further to evaluate whether expression of this oncoprotein has relation with grade of tumour and invasion of muscle.The objective of this study is to evaluate the expression of HER-2 protein in low grade, high grade and muscle invasive transitional cell carcinoma using immunohistochemistry.