HER2 copy number quantification in primary tumor and cell-free DNA provides additional prognostic information in HER2 positive early breast cancer

Chen, Xiaobin; Lin, Yuxiang; Jiang, Zhengwen; Li, Yan; Zhang, Yihua; Wang, Ying; Feng, Yang; Guo, Wenhui; Chen, Lili; Chen, Minyan; Zhang, Wenzhe; Fu, Fangmeng

doi:10.1016/j.breast.2022.02.002

The Breast

2022

DOI: 10.1016/j.breast.2022.02.002

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HER2 copy number quantification in primary tumor and cell-free DNA provides additional prognostic information in HER2 positive early breast cancer

Xiaobin Chen

Yuxiang Lin

Zhengwen Jiang

et al.

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Cited by 3 publications

(1 citation statement)

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“…We should be aware of the potential confounding effect of other genetic alterations, though. Other genetic determinants include the number of copies of the HER2 gene, the variant T allele of the PvuII gene in the ESR1 gene, the expression of the cyclin-dependent kinase inhibitor 2B antisense RNA 1 gene, and the rs2383207 variant [ 2 3 4 ]. The effects of the confounding factors should be evaluated if additional research is intended.…”

mentioning

confidence: 99%

Somatic Mutations of TP53 and Prognostic Factors for Primary Operable Breast Cancer: Correspondence

Sookaromdee¹,

Wiwanitkit

2022

J Breast Cancer

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mentioning

confidence: 99%

Somatic Mutations of TP53 and Prognostic Factors for Primary Operable Breast Cancer: Correspondence

Sookaromdee¹,

Wiwanitkit

2022

J Breast Cancer

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Zebrafish: unraveling genetic complexity through duplicated genes

Tasnim,

Wahlquist,

Hill

2024

Dev Genes Evol

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The zebrafish is an invaluable model organism for genetic, developmental, and disease research. Although its high conservation with humans is often cited as justification for its use, the zebrafish harbors oft-ignored genetic characteristics that may provide unique insights into gene structure and function. Zebrafish, along with other teleost fish, underwent an additional round of whole genome duplication after their split from tetrapods—resulting in an abundance of duplicated genes when compared to other vertebrates. These duplicated genes have evolved in distinct ways over the ensuing 350 million years. Thus, each gene within a duplicated gene pair has nuanced differences that create a unique identity. By investigating both members of the gene pair together, we can elucidate the mechanisms that underly protein structure and function and drive the complex interplay within biological systems, such as signal transduction cascades, genetic regulatory networks, and evolution of tissue and organ function. It is crucial to leverage such studies to explore these molecular dynamics, which could have far-reaching implications for both basic science and therapeutic development. Here, we will review the role of gene duplications and the existing models for gene divergence and retention following these events. We will also highlight examples within each of these models where studies comparing duplicated genes in the zebrafish have yielded key insights into protein structure, function, and regulation.

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Circulating tumor DNA for predicting recurrence in patients with operable breast cancer: a systematic review and meta-analysis

Nader-Marta,

Monteforte,

Agostinetto

et al. 2024

ESMO Open

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HER2 copy number quantification in primary tumor and cell-free DNA provides additional prognostic information in HER2 positive early breast cancer

Cited by 3 publications

References 46 publications

Somatic Mutations of TP53 and Prognostic Factors for Primary Operable Breast Cancer: Correspondence

Somatic Mutations of TP53 and Prognostic Factors for Primary Operable Breast Cancer: Correspondence

Zebrafish: unraveling genetic complexity through duplicated genes

Circulating tumor DNA for predicting recurrence in patients with operable breast cancer: a systematic review and meta-analysis

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