HER4 isoform CYT2 and its ligand NRG1III are expressed at high levels in human colorectal cancer

Guo, Yan; Duan, Zhihui; Jia, Yitao; Ren, Chaoying; Lv, Jian; Guo, Peng; Zhao, Wujie; Wang, Bin; Zhang, Suqiao; Li, Yaxing; Li, Zhongxin

doi:10.3892/ol.2018.8124

Cited by 4 publications

(4 citation statements)

References 28 publications

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“…Our results showed that CRC patients with high expressions of CXCL1, MS4A2, HDC, NRG1, and IL13 had a better OS. A number of recent studies found that CXCL1, MS4A, NRG1 and IL13 were highly expressed in a variety of tumors (22)(23)(24)(25)(26)(27). These results are not consistent with our research, and thus their unknown mechanism in CRC needs to be further explored.…”

Section: Discussioncontrasting

confidence: 84%

A New Prognostic and Therapeutic Immune-related Risk Signature of Colorectal Cancer

Huang

Feng

et al. 2021

Preprint

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BackgroundAlthough some advanced colorectal cancer (CRC) patients could select immunotherapy, but still most microsatellite stability (MSS) CRC patients did not respond. Our present study aims to set up a novel system for prognostic prediction and immunotherapeutic responsiveness for MSS CRC patients.MethodsUnivariable Cox regression survival analysis and least absolute shrinkage and selector operation (LASSO) regression analysis were performed to identify prognostic genes and establish immune risk signatures. Multivariate Cox regression analysis was performed to verify whether these clinical features could predict prognosis. R package was used to analyze the relationship between the immune-related risk model and these immune cells, effector molecules, and immune checkpoints.ResultsWe constructed an immune-related signature and verified its predictive capability. Immune-related signature included 12 differentially expressed IRGs (12 DE IR MSSGs), including CXCL1, CD36, FABP4, MS4A2, NRG1, VGF, GRP, HDC, XCL1, NGF, MAGEA1, and IL13. The signature consisting of 12 DE IR MSSGs was an independent and effective prognostic factor for the overall survival of CRC patients. In addition, the signature consisting of 12 DE IR MSSGs reflected the infiltration characteristics of different immunocytes in tumor immune microenvironment. The signature consisting of 12 DE IR MSSGs also had a significant correlation with immune checkpoint molecules.

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Section: Discussioncontrasting

confidence: 84%

A New Prognostic and Therapeutic Immune-related Risk Signature of Colorectal Cancer

Huang

Feng

et al. 2021

Preprint

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“…Wang et al (11) showed that Her4 expression promotes osteosarcoma cell proliferation and tumorigenesis, and reduced apoptosis both in vitro and in vivo. in our previous study, cYT-2, but not cYT-1, could significantly promote CRC progression (12).…”

Section: Introductionmentioning

confidence: 71%

HER4 promotes the progression of colorectal cancer by promoting epithelial‑mesenchymal transition

Jia

Wang

et al. 2020

Mol Med Report

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colorectal cancer (crc) remains one of the most common cancer types worldwide. a few previous studies have examined whether Her4 may promote the progression of crc. The present study examined the associations among the expression levels of members of the Her family, and investigated the potential mechanism underlying the function of Her4 in crc cells. immunohistochemistry analysis was conducted to detect the expression levels of Her family members in patients with crc. Her4 expression was knocked down using short hairpin RNA in HCT116 cells, and confirmed by quantitative Pcr and western blotting. The proliferation and adhesion of crc cells were analyzed by ccK-8 assays and adhesive assays, respectively. Flow cytometry was used to measure cell apoptosis. Western blotting and immunofluorescence staining in CRC cells were performed to identify proteins related to epithelial-mesenchymal transition. The proportion of patients with crc presenting positive expression of the Her family members epidermal growth factor receptor (eGFr), Her2, Her3 and Her4 were 72.1, 45.2, 43.8 and 34.2%, respectively. no relationship was found between Her4 and eGFr, Her2 or Her3 expression. Higher expression of Her4 was positively associated with lymph node metastasis (P=0.039). in the present study, Her4 expression was found to be associated with an unfavorable clinical outcome in patients with crc (P logrank =0.020). cell proliferation was inhibited, and apoptosis was increased following Her4 knockdown. Furthermore, Her4 knockdown increased the expression of e-cadherin and decreased the expressions of n-cadherin and vimentin (P<0.05). Her4 expression was found to be unrelated to other Her family members. in the present study, positive expression of Her4 promoted the progression of crc through epithelial-mesenchymal transition.

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“…Additionally, NRG1 has been shown to promote the progression in breast cancer ( Tsai et al, 2003 ; Cheng et al, 2009 ; Momeny et al, 2015 ; Shu et al, 2022 ). NRG1III was upregulated in CRC but its exact role in CRC is uncertain ( Guo et al, 2018 ). GAP43 was shown to be a “growth” or “plasticity” protein, promoting neuronal growth and regenerating axons ( Piontek et al, 2002 ; Hocquemiller et al, 2010 ; Zhao et al, 2012 ).…”

Section: Discussionmentioning

confidence: 99%

Identification and validation of a novel stress granules-related prognostic model in colorectal cancer

Liu

Zhao

et al. 2023

Front. Genet.

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Aims: A growing body of evidence demonstrates that Stress granules (SGs), a non-membrane cytoplasmic compartments, are important to colorectal development and chemoresistance. However, the clinical and pathological significance of SGs in colorectal cancer (CRC) patients is unclear. The aim of this study is to propose a new prognostic model related to SGs for CRC on the basis of transcriptional expression.Main methods: Differentially expressed SGs-related genes (DESGGs) were identified in CRC patients from TCGA dataset by limma R package. The univariate and Multivariate Cox regression model was used to construct a SGs-related prognostic prediction gene signature (SGPPGS). The CIBERSORT algorithm was used to assess cellular immune components between the two different risk groups. The mRNA expression levels of the predictive signature from 3 partial response (PR) and 6 stable disease (SD) or progress disease (PD) after neoadjuvant therapy CRC patients’ specimen were examined.Key findings: By screening and identification, SGPPGS comprised of four genes (CPT2, NRG1, GAP43, and CDKN2A) from DESGGs is established. Furthermore, we find that the risk score of SGPPGS is an independent prognostic factor to overall survival. Notably, the abundance of immune response inhibitory components in tumor tissues is upregulated in the group with a high-risk score of SGPPGS. Importantly, the risk score of SGPPGS is associated with the chemotherapy response in metastatic colorectal cancer.Significance: This study reveals the association between SGs related genes and CRC prognosis and provides a novel SGs related gene signature for CRC prognosis prediction.

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HER4 isoform CYT2 and its ligand NRG1III are expressed at high levels in human colorectal cancer

Cited by 4 publications

References 28 publications

A New Prognostic and Therapeutic Immune-related Risk Signature of Colorectal Cancer

A New Prognostic and Therapeutic Immune-related Risk Signature of Colorectal Cancer

HER4 promotes the progression of colorectal cancer by promoting epithelial‑mesenchymal transition

Identification and validation of a novel stress granules-related prognostic model in colorectal cancer

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