Herbal formula (Danggui Beimu Kushen Wan) for prostate disorders: a systematic review of classical literature

Li, Hong; Hung, Andrew; Yang, Angela Wei Hong

doi:10.1016/j.imr.2019.08.006

Cited by 8 publications

(5 citation statements)

References 28 publications

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“…It has been confirmed by long-term clinical practice [7][8][9] that traditional Chinese medicine has the characteristics of "simple and cheap inspection" and it can cooperate with western medicine to strengthen the therapeutic effect in the treatment of urinary system diseases, reduce the adverse reactions of western medicine, improve the quality of life of patients, prolong survival, etc. Clinical experience has shown that [10,11] Danggui Beimu Kushen Pills plus and minus Xinjia Simiao San, plus and minus Zhibai Dihuang Pills, plus and minus Zishui Tiaogan Recipe, and other syndromes can be used for different syndrome types of urinary system diseases. It can not only significantly improve the clinical symptoms, reduce tumor tumors, alleviate adverse reactions such as immunotherapy but also improve the quality of life or prolong survival of RCC patients.…”

Section: Introductionmentioning

confidence: 99%

Effects of Angelica Fritillaria Kushen Pill on Renal Function and Immune Function after Laparoscopic Radical Nephrectomy for Patients with Renal Carcinoma

Wang

Liu

Zhou

et al. 2022

Journal of Healthcare Engineering

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Objective. To investigate the effect of Danggui Beimu Kushen Pills on renal cell carcinoma patients undergoing laparoscopic radical resection and their effects on renal function and immune function. Methods. 106 patients with renal cell carcinoma who underwent retroperitoneal laparoscopic radical surgery in our hospital from March 2015 to February 2017 were selected, and they were divided into control group and treatment group. The control group was treated with interferon and the treatment group was treated with Danggui Beimu Kushen pills on the basis of the control group. The clinical efficacy, incidence of adverse reactions, survival rate, and the relationship with clinical stages were detected in the two groups. The renal function index levels, immune function index levels, and quality of life levels were measured in the two groups after treatment. Results. Compared with the control group, the total clinical effective rate was increased, the abnormal renal function, abnormal liver function, and platelet decline were decreased, and the survival rate was significantly elevated in the treatment group. The patients with clinical stage I∼II’ survival rate was increased, relative to patients with clinical stage III. After treatment, the levels of β2-MG, SCr, BUN, and CD8+ in the two groups were decreased, while the levels of CD3+, CD4+, and CD4+/CD8+ were increased. Moreover, the scores of physical function, social function, emotional function, role function, cognitive function, and total score of the two groups were improved. Compared with the control group, the treatment group changes were more obvious. Conclusion. The Danggui Beimu Kushen Pill has significant clinical effects on the treatment of renal cancer, which can improve the clinical symptoms, enhance the immune function, restore the health renal function, improve the quality of life, prolong the survival time of patients, reduce the incidence of adverse reactions, and provide high safety.

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Section: Introductionmentioning

confidence: 99%

Effects of Angelica Fritillaria Kushen Pill on Renal Function and Immune Function after Laparoscopic Radical Nephrectomy for Patients with Renal Carcinoma

Wang

Liu

Zhou

et al. 2022

Journal of Healthcare Engineering

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“…Traditional Chinese medicine has good curative effect and broad application prospect in alleviating IHD. The herb pair (combination of two drugs) is the most basic constituent unit of a traditional Chinese medicine compound, and it still has therapeutic characteristics and clinical significance in Chinese herbal medicine (CHM) [ 19 ]. Angelica and Sophora flavescens are traditional Chinese medicines widely used in the treatment of IHD [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Protective effect and mechanism of different proportions of “Danggui-Kushen” herb pair on ischemic heart disease

Yuan,

Liu,

Dong

et al. 2023

Heliyon

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“…Danggui Beimu Kushen Wan (DBKW; Chinese Angelica, Fritillaria and Flavescent Sophora Pill), also known as Guimu Kushen Wan or Kushen Wan, is a classical herbal formula that was initially recorded in the Jin Gui Yao Lue (Synopsis of Prescriptions of the Golden Chamber; ZHANG, Zhongjing; 205 AD), containing Angelicae Sinensis Radix (ASR; Dang gui), Fritillariae Thunbergii Bulbus (FTB; Zhe bei mu) and Sophorae Flavescentis Radix (SFR; Ku shen) 21 . Our previously published reviews have revealed that this formula has been used for managing urinary-related disorders for thousands of years 22 , 23 and it has been extended to manage a wide range of malignant tumours in clinical practice, such as PCa 24 , 25 , cervical cancer 24 , bladder cancer 24 , liver cancer 26 and vulvar basal cell carcinoma 27 . Nowadays, it has still been widely used and shown to be effective in clincial practice at treating a number of urinary system diseases involving PCa 24 .…”

Section: Introductionmentioning

confidence: 99%

Herb-target virtual screening and network pharmacology for prediction of molecular mechanism of Danggui Beimu Kushen Wan for prostate cancer

Hung

Yang

2021

Sci Rep

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Prostate cancer (PCa) is a cancer that occurs in the prostate with high morbidity and mortality. Danggui Beimu Kushen Wan (DBKW) is a classic formula for patients with difficult urination including PCa. This study aimed to investigate the molecular mechanisms of DBKW for PCa. We obtained DBKW compounds from our previous reviews. We identified potential targets for PCa from literature search, currently approved drugs and Open Targets database and filtered them by protein–protein interaction network analysis. We selected 26 targets to predict three cancer-related pathways. A total of 621 compounds were screened via molecular docking using PyRx and AutoDock Vina against 21 targets for PCa, producing 13041 docking results. The binding patterns and positions showed that a relatively small number of tight-binding compounds from DBKW were predicted to interact strongly and selectively with three targets. The top five high-binding-affinity compounds were selected to generate a network, indicating that compounds from all three herbs had high binding affinity against the 21 targets and may have potential biological activities with the targets. DBKW contains multi-targeting agents that could act on more than one pathway of PCa simultaneously. Further studies could focus on validating the computational results via experimental studies.

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Herbal formula (Danggui Beimu Kushen Wan) for prostate disorders: a systematic review of classical literature

Cited by 8 publications

References 28 publications

Effects of Angelica Fritillaria Kushen Pill on Renal Function and Immune Function after Laparoscopic Radical Nephrectomy for Patients with Renal Carcinoma

Effects of Angelica Fritillaria Kushen Pill on Renal Function and Immune Function after Laparoscopic Radical Nephrectomy for Patients with Renal Carcinoma

Protective effect and mechanism of different proportions of “Danggui-Kushen” herb pair on ischemic heart disease

Herb-target virtual screening and network pharmacology for prediction of molecular mechanism of Danggui Beimu Kushen Wan for prostate cancer

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