Herbal medicine for benign prostatic hyperplasia

Kim, Ji Hwan; Park, Kyung Moo; Lee, Ju Ah

doi:10.1097/md.0000000000014023

Cited by 6 publications

(2 citation statements)

References 19 publications

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“…Prostate illness may occur as a result of an imbalance between oxidative stress and the cell's antioxidant system [6]. The existing treatment options for BPH include drug therapy with α-blockers or 5α-reductase inhibitors, minimally invasive therapy and surgery [7]. The mechanism of α-blocker involves the relaxation of the smooth muscles of the prostate and the bladder neck thereby relieving lower urinary symptoms (LUTs) and urinary obstruction caused by an inflamed prostate [8].…”

Section: Introductionmentioning

confidence: 99%

Effects of Aqueous Fruit Extract of Annona muricata on Testosterone Propionate Induced Benign Prostate Hyperplasia (BPH) in Male Wistar Rats

Leje,

U.,

Yeldu

et al. 2024

Asian J. Res. Biochem.

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Introduction: Benign prostate hyperplasia (BPH) is an age-related non-malignant prostate gland enlargement in men that leads to pain and difficulty voiding urine. The etiology of BPH is still unknown. Studies have been reported on the effects of Annona muricata (soursop) against benign prostatic hyperplasia (BPH) with little documentation. Aim: This study aimed to determine the effects of aqueous fruit extract of A. muricata on testosterone propionate induced benign prostate hyperplasia (BPH) in male Wistar Rats. Methodology: The fruits of A. muricata were processed to obtain fruit extract and phytoconstituents. An acute toxicity study was conducted with six doses of A. muricata fruit extract (10, 100, 1000, 1500, 2900 and 5000 mg/kg) to determine the safety and tolerability dose limit. A total of 48 adult male Wistar rats were used for the study. After 2 weeks of acclimatization, the animals were orchimetized. The rats were randomly divided into six groups of eight animals each; group 1 (normal control + sham treated + distilled water); groups 2 (positive control + castrated + TP/day); group 3 (finasteride (3 mg/kg) + castrated + TP/day); group 4 (100 mg/kg AM + castrated + TP/day); group 5 (200 mg/kg AM + castrated + TP/day) and group 6 (400 mg/kg AM + castrated + TP/day) for 42 days. On the 43rd day animals were euthanized, blood and prostate tissue samples were collected for biochemical and histological study. Results: This study showed that, the extract significantly (p < 0.05) decreased both the prostate weight and testosterone levels in a dose-dependent manner compared to finasteride-treated rats. The effect of the extract on the histology of the prostate had significant recovery and was able to restore the enlarged prostate to near-normal in a dose-dependent manner. A significant (p < 0.05) recovery was observed at a higher dose (400 mg/kg) of the extracts. Conclusion: The effects of Annona muricata (soursop) against benign prostatic hyperplasia (BPH) showed inhibitory potentials via decreased prostate weight, prostate specific antigen, and testosterone levels in a dose-dependent manner. At a high dose (400 mg/kg) body weight of rats had significant recovery (p < 0.05) restoring prostatic histoarchitecture to near-normal. This study suggests that Annona muricata fruit may be considered a treatment option for benign prostatic hyperplasia in men.

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Section: Introductionmentioning

confidence: 99%

Effects of Aqueous Fruit Extract of Annona muricata on Testosterone Propionate Induced Benign Prostate Hyperplasia (BPH) in Male Wistar Rats

Leje,

U.,

Yeldu

et al. 2024

Asian J. Res. Biochem.

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“…Recent research suggests that herbs used in oriental medicine can effectively treat BPH or inhibit the occurrence of BPH [ 13 , 14 , 15 ]. These herbal extracts contain alkaloids, flavonoids, isoflavones, saponins, and other phenolics.…”

Section: Introductionmentioning

confidence: 99%

Extracts of Phyllostachys pubescens Leaves Represses Human Steroid 5-Alpha Reductase Type 2 Promoter Activity in BHP-1 Cells and Ameliorates Testosterone-Induced Benign Prostatic Hyperplasia in Rat Model

et al. 2021

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Benign prostatic hyperplasia (BPH) is the most common symptomatic abnormality of the human prostate characterized by uncontrolled proliferation of the prostate gland. In this study, we investigated the effect of bamboo, Phyllostachys pubescens, leaves extract (PPE) on human 5α-reductase type 2 (SRD5A2) gene promoter activity in human prostate cell lines and the protective effect of PPE on a testosterone-induced BPH rat model. PPE repressed human SRD5A2 promoter activity and its mRNA expression. The rats treated with PPE for 4 weeks showed a significantly attenuated prostate weight compared to vehicle control. PPE-treated rats also showed reduced serum dihydrotestosterone, testosterone, prostate-specific antigen, and SRD5A2 levels by testosterone injection. Quantitative real-time polymerase chain reaction showed that PPE treatment significantly decreased mRNA expression of SRD5A2, androgen receptor (AR), proliferating cell nuclear antigen (PCNA), and fibroblast growth factor 2 compared with the vehicle-treated, testosterone-injected rats in the prostate. Furthermore, PPE treatment showed reduced AR, PCNA, and tumor necrosis factor alpha expression in the prostate via immunohistofluorescence staining. In conclusion, oral administration of PPE prevented and inhibited the development and progression of enlarged prostate lesions in testosterone-induced animal models through various anti-proliferative and anti-inflammatory pharmacological effects and induced suppression of SRD5A2 gene expression.

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Effect of methanol extract of Plectranthus esculentus N.E.Br tuber and its fractions on indices of benign prostatic hyperplasia in Wistar rats

Kanu,

Ejezie,

Ejezie

et al. 2024

Journal of Ethnopharmacology

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Herbal medicine for benign prostatic hyperplasia

Cited by 6 publications

References 19 publications

Effects of Aqueous Fruit Extract of Annona muricata on Testosterone Propionate Induced Benign Prostate Hyperplasia (BPH) in Male Wistar Rats

Effects of Aqueous Fruit Extract of Annona muricata on Testosterone Propionate Induced Benign Prostate Hyperplasia (BPH) in Male Wistar Rats

Extracts of Phyllostachys pubescens Leaves Represses Human Steroid 5-Alpha Reductase Type 2 Promoter Activity in BHP-1 Cells and Ameliorates Testosterone-Induced Benign Prostatic Hyperplasia in Rat Model

Effect of methanol extract of Plectranthus esculentus N.E.Br tuber and its fractions on indices of benign prostatic hyperplasia in Wistar rats

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