Herbal mouthwash based on Libidibia ferrea: microbiological control, sensory characteristics, sedimentation, pH and density

Abstract

Introduction Phytotherapy is the study of herbal medicines and their applicability to cure diseases in general, being a therapeutic method which can be used for the prevention and treatment of mouth diseases. Among the herbal studied, the Libidibia ferrea, known as jucá or ironwood, is widely used in folk medicine by presenting anti-inflammatory, analgesic, antimicrobial and antipyretic therapeutic properties. Objective To evaluate in vitro pharmacological stability of the Libidibia ferrea extract’s mouthwash (INPA - 228 022). Material and method It was held the mouthwash microbiological control by determining the total number of microorganisms and Salmonella sp, Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus; stability characteristics (color, odor, brightness and consistency), sedimentation test (centrifuge), the pH measurement (pH meter) and density evaluation (pycnometer) were analyzed. Result The mouthwash showed to be absent from microorganisms and no changes were observed in the organoleptics and sedimentation characteristics. The average pH values were 6.21, 6.15 and 5.85 at 0, 30 and 60 days, respectively, and 1.029, 1.033 and 1.035 g/ mL density values, respectively, without interfering with the final characteristic of the formulation. Conclusion The mouthwash presented pharmacological stability and quality conditions.

Susceptibility of cariogenic microorganisms to phytoconstituents

“…However, mechanical control is not always appropriate, especially in situations that limit its performance for instance; bedridden individuals admitted to intensive care, those with impaired motor coordination, orthodontic brace users, and people at high risk for the disease. These factors reinforce the importance antimicrobial substances used in compliment to promote oral health (Venâncio et al, 2015).…”

“…Dental caries and periodontal disease are the most common diseases of the human oral cavity, involving bacterial adhesion to both natural and restored tooth surfaces, and the development of biofilms (Venâncio et al, 2015). Tooth decay (carie) is a disease of tooth surface demineralization; caused by the acids produced by bacteria thru fermentation of dietary carbohydrates (Leites et al, 2006).…”

“…Currently, chlorhexidine gluconate (by its proven efficacy in chemical removal of cariogenic or periodontal-pathogenic biofilms), stands out among the antimicrobials used to fight oral microorganisms (Venâncio et al, 2015). However, given the limitations of this agent, (such as staining of the tooth surface, taste changes, and micro-biotic imbalances), other, naturally occurring agents have been investigated (Lawrence et al, 2008;Khan et al, 2009).…”

Biopharmaceutical Products and Biomaterials of the Amazon Region Used in Dentistry

“…Since phytotherapy is a feasible method for the control and prevention of the development of oral pathologies, with the additional possibility of incorporating phyto-derived compounds into biomaterials, the discovery of new phytotherapic compounds has been of high relevance to dentistry [5,14,[19][20][21][22]. Brazil has an advantage in this market because it has the greatest biodiversity in the world, especially in the Amazo nian Region, and a genetic heritage of great potential for the development of new herbal products [23], especially in dentistry.…”

Formulasi dan Evaluasi Larutan Pencuci Mulut dengan Bahan Antimikroba Senyawa 1,5-Bis (3’-Etoksi-4’-Hidroksifenil)-1,4-Pentadien-3-on

“…Bahan aktif yang digunakan antara lain menthol, thymol, hexetidine, dan metil salisilat. Berbagai penelitian tentang formulasi dan evaluasi larutan pencuci mulut dengan bahan aktif kimia maupun alami juga telah banyak dilakukan, antara lain : larutan pencuci mulut dengan bahan aktif ekstrak poliherbal (10,11) , rosmarinus officinalis (12) , euphorbia hirta (13) , libidibia ferrea (14) . Pada penelitian ini dilakukan formulasi dan evaluasi larutan pencuci mulut dengan menggunakan senyawa EHP sebagai bahan antimikroba.…”