Herbicidal activity and biochemical characteristics of the botanical drupacine against Amaranthus retroflexus L.

Yu, Hualong; TIAN, Ci; SHEN, Rong-yan; Zhao, han; Dong, Jingao; ZHANG, Li-hui; Ma, Shujie

doi:10.1016/j.jia.2022.08.120

Cited by 6 publications

(3 citation statements)

References 38 publications

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“…Molecular docking simulations indicated that drupacine has a higher binding energy with SDH. As a result, the inhibition of SDH by drupacine could potentially disrupt the biosynthesis of aromatic amino acids, leading to abnormal growth and eventual death of weed seedlings [21].…”

Section: Introductionmentioning

confidence: 99%

Unraveling Shikimate Dehydrogenase Inhibition by 6-Nitroquinazoline-2,4-diol and Its Impact on Soybean and Maize Growth

Almeida,

Abrahão,

Seixas

et al. 2024

Agronomy

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The shikimate pathway is crucial for the biosynthesis of aromatic amino acids in plants and represents a promising target for developing new herbicides. This work aimed to identify inhibitors of shikimate dehydrogenase (SDH), a key enzyme of the shikimate pathway that catalyzes the conversion of 3-dehydroshikimate to shikimate. Virtual screening and molecular dynamic simulations were performed on the SDH active site of Arabidopsis thaliana (AtSDH), and 6-nitroquinazoline-2,4-diol (NQD) was identified as a potential inhibitor. In vitro assays showed that NQD decreased the activity of AtSDH by reducing Vmax while keeping KM unchanged, indicating non-competitive inhibition. In vivo, hydroponic experiments revealed that NQD reduced the root length of soybean and maize. Additionally, NQD increased the total protein content and certain amino acids. Soybean roots uptake NQD more efficiently than maize roots. Furthermore, NQD reduced shikimate accumulation in glyphosate-treated soybean roots, suggesting its potential to restrict the flow of metabolites along the shikimate pathway in soybean. The simultaneous treatment of maize seedlings with glyphosate and NQD accumulated gallic acid in the roots, indicating that NQD inhibits SDH in vivo. Overall, the data indicate that NQD inhibits SDH both in vitro and in vivo, providing valuable insights into the potential development of herbicides targeting SDH.

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Section: Introductionmentioning

confidence: 99%

Unraveling Shikimate Dehydrogenase Inhibition by 6-Nitroquinazoline-2,4-diol and Its Impact on Soybean and Maize Growth

Almeida,

Abrahão,

Seixas

et al. 2024

Agronomy

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show abstract

“…However, the excessive and inappropriate use of some herbicides, such as traditional synthetic herbicides, has not only led to high toxicities and severe environmental contamination, but also resulted in herbicidal resistance and other undesired side effects. − Therefore, the development of eco-friendly substitutes with high efficacy and low toxicity is highly recommended. Relative to synthetic herbicides, botanical herbicides, mainly extracted or derived from plants, have emerged as a preferred alternative in the fight against weeds. − …”

Section: Introductionmentioning

confidence: 99%

“…13 C NMR (100 MHz, CD 3 OD) δ (ppm): 171 8,. 165.7, 106.7, 62.4, 44.7, 44.3, 43.1, 42.3, 38.2, 36.2, 33.1, 30.0, 29.2, 29.1, 28.31, 24.9, 20.6.…”

mentioning

confidence: 99%

Longifolene-Derived Primary Amine Carboxylates for Sustainable Weed Management: Synthesis and Herbicidal Activity

Huang,

Lu,

Lan

et al. 2024

J. Agric. Food Chem.

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Twelve novel longifolene-derived primary amine carboxylates were synthesized and evaluated for herbicidal activity. The structures of title compounds were confirmed by Fourier-transform infrared spectroscopy, 1 H nuclear magnetic resonance (NMR), 13 C NMR, and high-resolution mass spectrometry. The results showed that all the synthesized compounds exhibited higher herbicidal activity than the corresponding carboxylic acids involved in the reaction and the commercial herbicide glyphosate; some of them even possessed inhibition rates of 100% against Lolium multiflorum Lam. and Brassica campestris at low concentrations (0.039−0.313 mmol/L). Moreover, structural factors, including types of carboxylates and carbon chain length, had a great influence on the herbicidal performance. The herbicidal activity of dicarboxylates was similar to or much higher than that of corresponding monocarboxylates and glyphosate. Furthermore, compound 5l was found to be the most active candidate against the root and shoot growth of L. multiflorum Lam. and B. campestris with half maximal inhibitory concentrations (IC 50 ) of around 0.010 and 0.023 mmol/L. The present work indicated that those prepared compounds have great potential to serve as high-performance botanical herbicides used at low doses.

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The herbicidal activities and biochemical characteristics of isolates from Murraya microphylla

Cao,

Fu,

Xiao

et al. 2024

Industrial Crops and Products

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Herbicidal activity and biochemical characteristics of the botanical drupacine against Amaranthus retroflexus L.

Cited by 6 publications

References 38 publications

Unraveling Shikimate Dehydrogenase Inhibition by 6-Nitroquinazoline-2,4-diol and Its Impact on Soybean and Maize Growth

Unraveling Shikimate Dehydrogenase Inhibition by 6-Nitroquinazoline-2,4-diol and Its Impact on Soybean and Maize Growth

Longifolene-Derived Primary Amine Carboxylates for Sustainable Weed Management: Synthesis and Herbicidal Activity

The herbicidal activities and biochemical characteristics of isolates from Murraya microphylla

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