HerDing: herb recommendation system to treat diseases using genes and chemicals

Choi, Wonjun; Choi, Chan-Hun; Kim, Young Ran; Kim, Seon-Jong; Na, Chang-Su; Lee, Hyunju

doi:10.1093/database/baw011

Cited by 32 publications

(20 citation statements)

References 24 publications

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“…The species sources of the identified NPs were collected from the respective literatures or by using the NP name/structure to search the TCM-ID ( 22 ), TCM@Taiwan ( 23 ), TCMID ( 25 ), TCMSP ( 26 ), TM-MC ( 27 ), StreptomeDB ( 38 ) and HerDing ( 39 ) databases. While available, we also collected the collection location, earliest collection time (format: Year-Month, such as 2015-MAR), and organism part of the species for extracting the NP.…”

Section: Data Collection and Processingmentioning

confidence: 99%

NPASS: natural product activity and species source database for natural product research, discovery and tool development

Zeng

Zhang

et al. 2017

Nucleic Acids Research

195

120

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There has been renewed interests in the exploration of natural products (NPs) for drug discovery, and continuous investigations of the therapeutic claims and mechanisms of traditional and herbal medicines. In-silico methods have been employed for facilitating these studies. These studies and the optimization of in-silico algorithms for NP applications can be facilitated by the quantitative activity and species source data of the NPs. A number of databases collectively provide the structural and other information of ∼470 000 NPs, including qualitative activity information for many NPs, but only ∼4000 NPs are with the experimental activity values. There is a need for the activity and species source data of more NPs. We therefore developed a new database, NPASS (Natural Product Activity and Species Source) to complement other databases by providing the experimental activity values and species sources of 35 032 NPs from 25 041 species targeting 5863 targets (2946 proteins, 1352 microbial species and 1227 cell-lines). NPASS contains 446 552 quantitative activity records (e.g. IC50, Ki, EC50, GI50 or MIC mainly in units of nM) of 222 092 NP-target pairs and 288 002 NP-species pairs. NPASS, http://bidd2.nus.edu.sg/NPASS/, is freely accessible with its contents searchable by keywords, physicochemical property range, structural similarity, species and target search facilities.

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Section: Data Collection and Processingmentioning

confidence: 99%

NPASS: natural product activity and species source database for natural product research, discovery and tool development

Zeng

Zhang

et al. 2017

Nucleic Acids Research

195

120

View full text Add to dashboard Cite

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“…GHJTY is a complex herbal decoction composed of 18 plants; therefore, we previously used bioinformatics and screening experiments to select the five medicinal herbs present in GHJTY with the greatest potential to improve the efficacy and convenience of pharmaceutically prescribing GHJTY [ 5 ]. These five medicinal herbs include Ostericum koreanum Maximowicz (Osterici Radix; OK), Lonicera japonica Thunberg (Lonicerae Folium; LJ), Clematis mandshurica Ruprecht (Clematis Radix; CM), Angelica gigas Nakai (Angelicae Gigantis Radix; AG), and Phellodendron amurense Ruprecht (Phellodendri Cortex; PA).…”

Section: Introductionmentioning

confidence: 99%

Antiosteoarthritic Effects of ChondroT in a Rat Model of Monosodium Iodoacetate‐Induced Osteoarthritis

Bae

Jeong

Choi

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Ganghwaljetongyeum is a traditional Korean herbal medicine used to treat joint pain, limited motion, fever, and swelling; it also inhibits inflammatory processes associated with arthritis. ChondroT, a water extract of Ganghwaljetongyeum, is a new complex herbal medicine. This study investigated the effects of ChondroT using a rat model of monosodium iodoacetate- (MIA-) induced osteoarthritis. Thirty-six rats were randomly divided into three ChondroT groups and a normal, control, and positive control group. Changes in paw edema volume, histopathology, and plantar withdrawal response were analyzed. Further, inflammatory cytokines, arachidonic acids, liver and kidney function, and hematological features were measured. ChondroT significantly decreased paw edema by the 5th day and notably improved articular cartilage damage; it also significantly improved the plantar withdrawal response in terms of both reaction time and force intensity. Moreover, treatment with ChondroT significantly decreased the serum levels of tumor necrosis factor alpha, interleukin-1β, interleukin-6, and prostaglandin E2 and significantly increased serum aspartate aminotransferase and alanine aminotransferase levels. This study demonstrates that ChondroT has anti-inflammatory and analgesic effects in a MIA-induced osteoarthritis rat model. These results support the clinical relevance of ChondroT for future use in patients with osteoarthritis. However, further studies are required to elucidate the corresponding mechanisms.

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“…[ 5 ] It is a complex herbal decoction composed of 18 plants. In order to improve the efficacy and convenience of pharmaceutical prescription, a previous bioinformatics study [ 6 ] identified the 5 medicinal herbs with the greatest potential. These were Ostericum koreanum Maximowicz (Osterici Radix, OK), Lonicera japonica Thunberg (Lonicerae Folium, LJ), Clematis mandshurica Ruprecht (Clematis Radix, CM), Angelica gigas Nakai (AngelicaeGigantis Radix, AG), and Phellodendron amurense Ruprecht (Phellodendri Cortex, PA).…”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of ChondroT on knee-osteoarthritis

Lee

Kim

2018

Medicine

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Background:Arthritis is the most common disease in elderly individuals. Many medications for osteoarthritis treatment have the potential for side effects. Using a bioinformatics tool and preclinical studies, ChondroT, 5 herbal complexes, was identified from Ganghwaljetongyeum, which is a18 herbal complex, which has often used to treat osteoarthritis. The goal of this study is to evaluate short-term safety of ChondroT.Methods:This will be a multicenter, randomized, double-blind, and placebo-controlled trial. There will be a 2-week run-in period before random allocation to 3 groups, ChondroT 1.0 g, 2.0 g, and placebo groups. Total duration of the clinical trial will be 14 weeks including a 4-week washout follow-up. Participants will be followed-up every 4 weeks, and the effect and the safety will be assessed at visit 2, 3, and 4. All participants are asked to maintain the medication schedule in this protocol. The primary outcome will be measured using pain visual analog scale (VAS) after 8 week treatment and secondary outcomes will include pain VAS score after 4 week treatment, SF-36 survey score, patient's global assessment, physical function test, and the change of erythrocyte sedimentation rate, and C-reactive protein. The repeated-measure analysis will be used for the primary efficacy based on full analysis set and per-protocol.Discussion:This study has restrictive inclusion, exclusion criteria, and a well-controlled intervention, and it will be the first randomized controlled trial to evaluate the efficacy and safety of ChondroT formula in osteoarthritis patients. The trial according to this protocol may provide a new intervention in the treatment of osteoarthritis.

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HerDing: herb recommendation system to treat diseases using genes and chemicals

Cited by 32 publications

References 24 publications

NPASS: natural product activity and species source database for natural product research, discovery and tool development

NPASS: natural product activity and species source database for natural product research, discovery and tool development

Antiosteoarthritic Effects of ChondroT in a Rat Model of Monosodium Iodoacetate‐Induced Osteoarthritis

Efficacy and safety of ChondroT on knee-osteoarthritis

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