Hereditary essential tremor in Buenos Aires (Argentina)

Herskovits, E; Figueroa, Edgar Humberto Cortés; Mangone, Carlos A.

doi:10.1590/s0004-282x1988000300002

Cited by 4 publications

(2 citation statements)

References 18 publications

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“…Headhoice tremor occurs more often and is more severe in women. It has previously been reported that headhoice tremor occurs in -30% of ET patients (4,5,8,(11)(12)(13). This estimate closely agrees with our observations among male patients.…”

Section: Discussionmentioning

confidence: 98%

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Clinical expression of essential tremor: Effects of gender and age

et al. 1997

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Essential tremor (ET) is considered to be a monosymptomatic disorder consisting primarily of postural hand tremor. Nevertheless, clinical expression can vary based on the body region affected by tremor and the coexistence of other neurologic signs, such as tandem gait disturbance. We conducted a two-part study to test the hypothesis that variability in ET clinical expression is influenced by gender and age. In part 1, we examined a large ET clinical database (n = 450), comparing ratings of postural hand and head/voice tremor based on gender. Head/voice tremor was significantly more frequent and more severe among female ET patients; men had more severe postural hand tremor. In part 2, ET patients (n = 40) had significantly more missteps when tandem walking in comparison to age-matched controls. Poor tandem walk in ET cases was associated with more advanced age, but not gender, disease duration, or ratings of postural hand or head/voice tremor. We conclude that gender influences the body region most affected by ET possibly through the effects of the sex chromosomes or hormones. Ataxia (tandem gait difficulty) is common in ET and may be an accentuation of cerebellar dysfunction due to aging.

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Section: Discussionmentioning

confidence: 98%

“…ET appears most frequently in the hands: -90% of ET patients have hand tremor (4,5,8,(11)(12)(13). The next most frequently affected body area is the cranial musculature, with headhoice tremor affecting -30% of patients; other body regions are much more rarely affected.…”

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confidence: 99%

Clinical expression of essential tremor: Effects of gender and age

et al. 1997

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Epidemiology and Genetics of Essential Tremor

Brin

Koller

2008

Mov. Disord.

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Summary: Essential tremor (ET) is one of the most common movenient disorders. Howevcr. the etiology and pathogenesis are as yet unknown. Continued research will give us clues to understanding the impact o n society. identifying genetic and environmental contributors t o the disease, understanding the significance of a sporadic case. the phenotypic spectrum and timing of presentation. and the relationship with other neurologic disorders. Because the condition is both clinically and genetically heterogeneous and there is overlap with these other disorders, such as dystonia, parkinsonism. peripheral neuropathy. and migraine, the definition of phenotype plagues research in this area. Advances in understanding the genetic and molecular underpinnings of tremor should provide additional tools to unravel the clinical phenotype (including physiology). genotype-phenotype relationships, and the epidemiology of tremor.

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Essential tremor: clinical observations

Pereira

Pimentel

Nicaretta

1993

Arq. Neuro-Psiquiatr.

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Hospital Universitário Pedro Ernesto -UERJ, quanto a história fiamiliar, sexo, idade e áreas de acometimento corporal. Dos pacientes avaliados, somente 37,70% apresentavam história familiar para T E .Observa-se predomínio do sexo feminino (56,60%) em relação ao masculino (43,40%) e da raça branca (69,80%) sobre as demais, entretanto, não se pode afirmar que esta diferença seja estatisticamente significativa, por não se dispor de dados populacionais. Nossos achados mostraram maior incidência após os 50 anos de idade, predominando nas 6* e 7* décadas, principalmente nesta última. O acometimento das mãos (96,20%) prevaleceu sobre as demais áreas corporais: cefálico (28,30%), de voz (16,99%), de pernas (11,30%), de língua (3,78%) e de tronco (1,88%). Estes dificilmente se apresentavam isolados e ocorriam, em sua maioria, associados ao tremor de mãos. P A L A V R A S -C H A V E : tremor, tremor essencial, aspectos clínicos. Essential tremor: clinical observations. S U M M A R Y -T h e authors have studied 53 patients with essential tremor, focusing its clinical and epidemiological aspects.There were familial history in 37.70% of all cases, prevailing in females (56.60%) and white people (69.80%); nevertheless this difference dan not be assured from the statistical point of view due to lack of population data. W e agreed that the main incidence of this syndrome occurred beyond the 5th decade, specially during the 6th and 7th decades.Topographically, we could observe that the hand tremor predominated, with an incidence of 96.20% of the total number of cases, followed by head tremor (28.30%), voice tremor (16.99%), leg tremor (11.30%), tongue tremor (3.78%) and trunk tremor (1.88%). These focal tremors were seldom observed alone and we noted frequent association with hand tremor. K E Y W O R D S : tremor, essential tremor, clinical observations.O tremor essencial (TE) é distúrbio comum de movimento, apresentando-se tipicamente como tremor postural distai de membros superiores, podendo em alguns casos exacerbar-se ao movimento (tremor cinético). Dificilmente confundido com outras síndromes extrapiramidais importantes devido à sua caracte» rística rítmica e oscilatória, o diagnóstico clínico de certeza é feito na ausência de outros sinais ou sintomas neurológicos 3 " 5 . Deve-se, entretanto, ter em mente que distúrbios metabólicos, endócrinos ou psíquicos, entre outros, podem muitas vezes dificultar este diagnóstico. Apesar de ser mais comumente observado em idosos, o TE pode surgir em qualquer idade. Inicialmente manifesta-se unilateralmente, de forma intermitente, mas, uma vez estabelecido, tende a ser bilateral e invariavelmente assimétrico 1 » 4 . Qualquer segmento corpóreo pode ser acometido. As mãos são as áreas mais comumente afetadas, seguindo-se em frequência

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Hereditary essential tremor in Buenos Aires (Argentina)

Cited by 4 publications

References 18 publications

Clinical expression of essential tremor: Effects of gender and age

Clinical expression of essential tremor: Effects of gender and age

Epidemiology and Genetics of Essential Tremor

Essential tremor: clinical observations

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