Hereditary spastic paraplegia: clinical changes and association with neuroimaging findings.

Abstract

Hereditary spastic paraparesis is a group of diseases that have as their main clinical aspect weakness and spasticity in the lower limbs, associated with a large number of genes, but involving a more restricted number of cellular functions that cause dysfunction of the neurons that make up the corticospinal tract. We will present a series of 3 cases of our service, mainly addressing the relation between the neuroimaging findings and the clinical alterations observed, with later literature review, showing the importance of this relationship, since not all services have a molecular diagnostic service when the acquired causes are removed.