Heritability of variation of plasma cortisol levels

Aw, Meikle; Jd, Stringham; Mg, Woodward; Bishop, D. Timothy

doi:10.1016/0026-0495(88)90164-3

Cited by 132 publications

(62 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our estimate of hcritability (0.39) is much lower than the value obtained by Meikle et al [ 12] (58%) who used a sample of adult male twins, and much high er than the estimate of Rotter et al (12%), who used a random sample of nuclear families [14], Both of these studies used a square root transformation of DHEAS levels as we did in the current study. Rotter et al [14] found sig nificant amounts of dominance variation (53%).…”

Section: Discussioncontrasting

confidence: 52%

“…Serum levels of DHEAS are inversely related to levels of serum low density lipoprotein (LDL), triglyc eride and apoprotein B (ApoB) (a major pro tein component of LDL) levels in humans [11]. DHEAS also shows an inverse relation ship with angiographically defined atheroscle rosis [7], Previous studies have found evidence of a significant polygenic effect on serum DHEAS [12][13][14], Two of these studies have reported heritabilities of 60% or higher [12. 14].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Quantitative Genetics of Dehydroepiandrosterone Sulfate and Its Relation to Possible Cardiovascular Disease Risk Factors in Mexican Americans

et al. 1996

View full text Add to dashboard Cite

Dehydroepiandrosterone sulfate (DHEAS) is an adrenal steroid which has been inversely associated with development of atherosclerosis. We estimated heritability of serum DHEAS levels in 564 related Mexican Americans. We found a significant heritability for DHEAS (h² = 0.39, p < 0.001). Measures of alcohol consumption, reproductive status, body composition, and HDL₃ levels showed significant relationships with serum DHEAS levels. Sex and age were significantly associated with the mean, but not the genetic variance, of DHEAS levels. The results of this study demonstrate a significant genetic influence on steroid concentration and help to quantify the factors contributing to cardiovascular disease risk in Mexican Americans.

show abstract

Section: Discussioncontrasting

confidence: 52%

Section: Introductionmentioning

confidence: 99%

Quantitative Genetics of Dehydroepiandrosterone Sulfate and Its Relation to Possible Cardiovascular Disease Risk Factors in Mexican Americans

et al. 1996

View full text Add to dashboard Cite

show abstract

“…In addition, genetics affect both fat distribution and cortisol (20,41). Genetics may playa role in the relationship between excessive cortisol exposure and abdominal fat by influencing cortisol reactivity (or possibly affecting mood, which could influence cortisol exposure).…”

Section: Discussionmentioning

confidence: 99%

Stress‐Induced Cortisol, Mood, and Fat Distribution in Men

et al. 1999

View full text Add to dashboard Cite

Stress-induced cortisol, mood, and fat distribution in men. Obes Res. 1999;7:9-15. Objective: A previous study in our laboratory (Moyer et al., Obes Res. 1994;2:255-62 found that, in response to uncontrollable laboratory stress, women with a high waist-to-hip ratio (WHR) had higher cortisol reactivity, poorer coping skills, and lower anger responses than women with low WHR. We aimed to compare high WHR men's stress responses to these women. Research Methods and Procedures:The current study examined cortisol reactivity and psychological data of 27 healthy high WHR men exposed to the same laboratory challenges as the women from our previous study. Men's data are discussed in relation to that of the high and low WHR women.Results: Men responded to the stress with increases in both cortisol and blood pressure. In comparison with the high and low. WHR women, men had significantly higher total cortisof on the stress day. However, when comparing a subsample of men and women matched in WHR's, differences in cortisol secretion were greatly diminished and no longer significant. In addition, men had higher desire for control than both high and low WHR women, and lower mood reactivity than low WHR women. Despite the lower mood reactivity of high WHR groups, the high mood reactors among the high WHR women, and to a lesser extent, men, tended to have higher cortisol reactivity. differences and greater exposure to cortisol observed amon, the high WHR men and women may have played a role n contributing to their greater abdominal fat depots. Discussion

show abstract

“…Various data support the fact that inheritance plays a significant role in determining the circulating AA levels in normal individuals [93][94][95][96]. Circulating AA levels and their response to ACTH are highly individualized, compared to their secretion of glucocorticoids in normal women [97].…”

Section: Heritability Of Adrenal Steroidogenesis In Pcosmentioning

confidence: 95%

The adrenal and polycystic ovary syndrome

Yildiz

Azziz

2007

Rev Endocr Metab Disord

115

View full text Add to dashboard Cite

Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders characterized by androgen excess, oligo-ovulation and polycystic ovaries. Although ovaries are the main source of increased androgens in the syndrome, between 20 and 30% of patients with PCOS have adrenal androgen (AA) excess, detectable primarily by elevated dehydroepiandrosterone sulfate (DHEAS) levels. Patients with PCOS demonstrate a generalized hypersecretion of adrenocortical products, basally and in response to ACTH stimulation. The mechanisms of these abnormalities are unclear although AA excess in PCOS is likely a complex trait, modulated by both intrinsic and acquired factors. To date, no specific genetic defects have been identified. The production of AAs in response to ACTH appears to be closely related to altered factors regulating glucose-mediated glucose disposal, increased peripheral metabolism of cortisol, and to a less extent to the effects of extra-adrenal androgens, insulin resistance, hyperinsulinemia or obesity. Finally, DHEAS levels and the response of AAs to ACTH are relatively constant over time and are closely correlated between PCOS patients and their siblings suggesting that this abnormality is an inherited trait in PCOS.

show abstract

Heritability of variation of plasma cortisol levels

Cited by 132 publications

References 16 publications

Quantitative Genetics of Dehydroepiandrosterone Sulfate and Its Relation to Possible Cardiovascular Disease Risk Factors in Mexican Americans

Quantitative Genetics of Dehydroepiandrosterone Sulfate and Its Relation to Possible Cardiovascular Disease Risk Factors in Mexican Americans

Stress‐Induced Cortisol, Mood, and Fat Distribution in Men

The adrenal and polycystic ovary syndrome

Contact Info

Product

Resources

About