Herpes Esophagitis With Concomitant Eosinophilic Esophagitis in a Child: A Case Report

Cristoforo, Thomas A; Rietsma, Kristine; Wilsey, Alexander; Swan, Emily; Wilsey, Michael

doi:10.1177/0009922817730350

Cited by 3 publications

(2 citation statements)

References 13 publications

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“…We included all cases of HE, as defined by the World Health Organization, in immunocompetent adolescents aged between 10 and 19 years. In total, 36 cases were identified [4,[6][7][8][9][10][11][12][13][14][15][16][17][18]; the clinical characteristics of the patients are shown in Table 1. The mean age was 15.097 ± 2.736 years, and the male: female ratio was 6.2:1.…”

Section: Discussionmentioning

confidence: 99%

Rare Etiology of Odynophagia in a Female Adolescent

Koutsoumourakis

Gagalis

Fotoulaki

et al. 2021

Case Rep Gastroenterol

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Herpes esophagitis (HE) is a rare condition in immunocompetent adolescents. However, it commonly occurs as a primary infection in younger individuals. Herein, we report a 16-year-old female patient who had a history of fever for 5 days, odynophagia, and orolabial herpes infection for 7 days. Clusters of painful vesicles on an erythematous base on the lips, gingiva, and palate were observed on physical examination. Further, esophagogastroduodenoscopy revealed diffuse linear ulcerations in the distal esophagus. The patient then received the following treatment: intravenous (I.V.) acyclovir 5 mg/kg three times a day, I.V. omeprazole 40 mg two times a day, and acyclovir 5% cream four times a day. After 8 days of admission, the patient was discharged. A follow-up esophagogastroduodenoscopy was performed 7 weeks after discharge, and the results revealed that the esophageal mucosa had a normal appearance. The effect of antiviral treatment against HE remains unknown in these patients. Nevertheless, it is believed to accelerate the healing process in individuals with esophageal mucosal barrier damage. To the best of our knowledge, this case of a female adolescent with an intact immune system is the sixth case of herpes simplex esophagitis to be reported in the literature.

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Section: Discussionmentioning

confidence: 99%

Rare Etiology of Odynophagia in a Female Adolescent

Koutsoumourakis

Gagalis

Fotoulaki

et al. 2021

Case Rep Gastroenterol

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“…The link between EoE and HSV esophagitis has been reported in some cases in Western countries [5-7,10-12,16-18]. There has been debate as to whether HSV esophagitis is the causative agent of EoE, or whether EoE is a predisposing factor for HSV esophagitis.…”

Section: Discussionmentioning

confidence: 99%

A Case of Eosinophilic Esophagitis Associated with Herpes Esophagitis in a Pediatric Patient

Kim¹,

Lee²,

Lee³

2019

Clin Endosc

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Eosinophilic esophagitis is a rare disease in Asian countries, but its incidence is growing rapidly in Western countries. The main pathophysiology of eosinophilic esophagitis is esophageal epithelial barrier dysfunction; disruption of the esophageal epithelial barrier easily induces antigen sensitization to foods and aeroallergens, which leads to subsequent esophageal inflammation as a result of eosinophil recruitment. Here we report a case of an 11-year-old Korean boy who suffered from fever, odynophagia, dysphagia, and chest pain. His upper endoscopic findings showed longitudinal ulcers with a volcano-like appearance at the distal esophagus. Polymerase chain reaction test results and biopsy specimens were positive for herpes simplex virus type 1. He was treated with acyclovir and a proton pump inhibitor, but his follow-up endoscopy showed typical patterns of eosinophilic esophagitis, and the biopsy specimens were compatible with the diagnostic criteria for eosinophilic esophagitis. Therefore, we report a very rare case of eosinophilic esophagitis after herpes esophagitis in a Korean child with normal immunity.

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Odynophagia in a young adult: revisiting herpetic esophagitis and eosinophilic esophagitis

et al. 2022

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An immunocompetent man in his 20s presented with a 24-hour history of severe odynophagia, nausea, vomiting and throat pain. Esophagogastroduodenoscopy (EGD) revealed severe esophagitis with ulcerated mucosa, exudative debris, haemorrhage and multiple erosions. Biopsy of the oesophageal tissue demonstrated marginated chromatin, multinucleated giant cells and molding of nuclei, consistent with herpes simplex virus esophagitis (HSE). Treatment with oral acyclovir led to the complete resolution of symptoms. The patient subsequently developed dysphagia again, 8 months later. EGD showed furrowing and concentric rings typical of eosinophilic esophagitis (EoE), a diagnosis confirmed by biopsy. Treatment with a proton pump inhibitor and swallowed topical corticosteroids led to symptomatic improvement. Thus, HSE can occur in immunocompetent hosts and on occasion, HSE may be a harbinger of EoE, as evidenced by our extensive literature review. Mechanical disruption of the mucosal barrier by viruses, facilitating food allergen penetration, and associated immunological signaling abnormalities may be responsible phenomena requiring further elucidation.

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Herpes Esophagitis With Concomitant Eosinophilic Esophagitis in a Child: A Case Report

Cited by 3 publications

References 13 publications

Rare Etiology of Odynophagia in a Female Adolescent

Rare Etiology of Odynophagia in a Female Adolescent

A Case of Eosinophilic Esophagitis Associated with Herpes Esophagitis in a Pediatric Patient

Odynophagia in a young adult: revisiting herpetic esophagitis and eosinophilic esophagitis

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