Herpes gestationis

Pemphigoid gestationis: A Moroccan study

“…Other histologic findings included dermal edema, mild perivascular inflammation with eosinophils, focal spongiosis, and epidermal ulceration. The histopathologic features of PG may vary greatly depending on the timing of the biopsy and the nature of the primary lesion [13][14][15]. Therefore, in many PG patients, nondiagnostic histologic findings are expected.…”

Pemphigoid Gestationis

“…1 The skin lesions resolve spontaneously in the fi rst months. 32 Immunofl uorescence of the newborn skin may be positive, even when there are no clinical symptoms of the disease. 18 33 34 When high doses of corticosteroids are given during pregnancy, the newborn baby must be examined immediately after delivery.…”

Neonatal pemphigus in an infant born to a mother with serologic evidence of both pemphigus vulgaris and gestational pemphigoid

“…6 Usually the eruption begins on the abdomen and subsequently spreads over the trunk, head, and extremities. 7 Less commonly, gestational pemphigoid involves the mucous membranes. 7 The autoimmune response is mediated by complement binding IgG antibodies to the noncollagenous domain, NC16a, of the180-kd hemidesmosomal antigen of basal keratinocytes (BPAg2 or Type XVII collagen).…”

“…7 Less commonly, gestational pemphigoid involves the mucous membranes. 7 The autoimmune response is mediated by complement binding IgG antibodies to the noncollagenous domain, NC16a, of the180-kd hemidesmosomal antigen of basal keratinocytes (BPAg2 or Type XVII collagen). 8 This disease typically flares with delivery and then spontaneously resolves within months without treatment.…”