Herpes Simplex Acyclovir-Resistant Mutant in Experimental Keratouveitis

Aciclovir‐resistant herpes keratitis

“…Local toxicity is a major complication with topical use. Experimental studies of aciclovir‐resistant HSV keratouveitis in rabbits have showed vidarabine to be efficacious 29 …”

“…As an oral formulation it has been used to treat herpes zoster infections 30 . Aciclovir‐resistant HSV strains have been reported to remain sensitive to Brivudin 29 . Hence this may be a possible therapy if required, although there is a lack of clinical trials to support this.…”

Resistant herpes simplex keratitis

“…Boisjoly et al. found that vidarabine topically was a possible alternative drug to acyclovir in treating resistant herpes simplex viral keratitis in rabbits 3 …”

“…Boisjoly et al found that vidarabine topically was a possible alternative drug to acyclovir in treating resistant herpes simplex viral keratitis in rabbits. 3 I also try topical vidarabine ointment in possible drugresistant herpetic keratitis. It is not toxic in the short run, for 2 or 3 weeks five times a day, and is certainly less toxic and less expensive than i.v.…”