Herpes simplex virus 2 encephalitis in a patient heterozygous for a TLR3 mutation

Abstract

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Humans with inherited MyD88 and IRAK-4 deficiencies are predisposed to hypoxemic COVID-19 pneumonia

“…TLR7deficient patients do not appear to be susceptible to common viral infections other than SARS-CoV-2, but further studies are required to confirm this. Indeed, TLR3 deficiency was initially reported in patients with herpes simplex encephalitis (Guo et al, 2011;Jouanguy et al, 2020;Zhang et al, 2007b), but patients with TLR3 deficiency were progressively found to be prone to other viral diseases too, including critical influenza pneumonia (Bucciol et al, 2022b;Kyung Lim et al, 2019), other types of viral encephalitis (Chen et al, 2021;Hautala et al, 2020;Kuo et al, 2022;Partanen et al, 2020), and hypoxemic COVID-19 pneumonia (Zhang et al, 2020b). Overall, our data suggest that MyD88 and IRAK-4 deficiencies underlie hypoxemic COVID-19 pneumonia.…”

Central Nervous System and Ocular Manifestations in Puumala Hantavirus Infection

“…It seems possible that PUUV encephalitis can be more common in populations with genetic susceptibility, especially in conjugation with endemically high NE frequencies. Similar genetic mechanisms have been described in encephalitis caused by herpes simplex virus 1 and 2 (HSV1 and HSV2), for example [16,17].…”

TINF2 is a major susceptibility gene in Danish patients with multiple primary melanoma

“…2022 52 has been associated with moderate risk of breast cancer and in a previous case report was found in a patient with normal telomere length. 53 …”