Herpes simplex virus infection in Bulgarian patients with neurological diseases

Shikova, Evelina; Alexandrova, Dora; Kumanova, Аntoniya; Tarnev, Ivailo; Vassileva, Evgenia; Pacheva, Iliyana; Galabova, Fani; Pishmisheva, Maria

doi:10.1016/j.jcvp.2022.100106

Cited by 2 publications

(1 citation statement)

References 33 publications

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“…Some studies reported HSV-2 as the most frequent herpes virus-causing CNS infection [ 18 ]. HSV-2 can cause adults with normal immune function to suffer from acute and subacute myelitis [ 19 ], brainstem encephalitis, encephalitis, and meningitis [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Fatal multiple organ dysfunction caused by commensal bacteria of urogenital tract infection in adult lung transplant recipients: two case reports

Tian

Han

et al. 2023

Virol J

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Background Infection following lung transplantation has been the focus of clinical concerns. The colonization rate of commensal bacteria of the urogenital tract, including Mycoplasma hominis, Ureaplasma urealyticum (UU), and herpes simplex virus type-2 (HSV-2), is high, which may cause secondary infection after transplantation. Case presentation Twenty-three-year-old and 67-year-old women underwent lung transplantation for different causes. Shortly after the operation, they developed perineal skin ulcers, hypoxia, and intractable epilepsy. Subsequent computed tomography (CT) of the chest showed lung consolidation, and cranial CT showed shallowing sulci and gyri. UU and HSV-2 were detected in bronchoalveolar lavage fluid by next-generation sequencing, and HSV-2 was shown in the cerebrospinal fluid of both patients. Despite active treatment, both suffered irreversible brain function damage within 72 h of the seizure. Conclusions Clinicians should know that commensal bacteria of urogenital tract infections can lead to fatal multiple organ dysfunction after lung transplantation.

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Section: Discussionmentioning

confidence: 99%

Fatal multiple organ dysfunction caused by commensal bacteria of urogenital tract infection in adult lung transplant recipients: two case reports

Tian

Han

et al. 2023

Virol J

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Metagenomic search of viral coinfections in herpes simplex encephalitis patients

Perlejewski,

Radkowski,

Rydzanicz

et al. 2023

J. Neurovirol.

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Little is known about concomitant central nervous system (CNS) infections by more than one virus. Current diagnostics are based on molecular tests for particular pathogens making it difficult to identify multi-viral infections. In the present study, we applied DNA- and RNA-based next-generation sequencing metagenomics (mNGS) to detect viruses in cerebrospinal fluids from 20 patients with herpes simplex encephalitis. Coinfection was detected in one patient: sequences in cerebrospinal fluids matched enterovirus A (2.660 reads; 4% of recovered genome) and enterovirus B (1.571 reads; 13% of recovered genome). Subsequent PCR combined with serotyping allowed to identify human echovirus 6, a representative of enterovirus B. Several other mNGS hits (human pegivirus, Merkel cell polyomavirus, human papillomavirus type 5) were not considered to represent a genuine signal as they could not be confirmed by specific RT-PCR/PCR. HSV DNA, while being detectable by PCR in every patient, was detected by mNGS in only one. In conclusion, contaminations and false signals may complicate mNGS interpretation; however, the method can be useful in diagnostics of viral coinfections in CNS, particularly in the case of rare pathogens.

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Herpes simplex virus infection in Bulgarian patients with neurological diseases

Cited by 2 publications

References 33 publications

Fatal multiple organ dysfunction caused by commensal bacteria of urogenital tract infection in adult lung transplant recipients: two case reports

Fatal multiple organ dysfunction caused by commensal bacteria of urogenital tract infection in adult lung transplant recipients: two case reports

Metagenomic search of viral coinfections in herpes simplex encephalitis patients

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